Therapy Detail

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Therapy Name 6MHP vaccine + CDX-1140 + NeoAg-mBRAF + Poly ICLC
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
6MHP vaccine 6MHP vaccine is a peptide vaccine containing 6 melanoma helper peptides as epitopes, which may stimulate TH1-biased immune response against tumor cells expressing these antigens (PMID: 25126421, PMID: 26258314).
CDX-1140 CDX 1140|CDX1140 CD40 Antibody 14 CDX-1140 is an antibody that binds CD40 and activates signaling, potentially resulting in enhanced anti-tumor immune response (Blood, 128(22), 1848, PMID: 30382327).
NeoAg-mBRAF NeoAg mBRAF|BRAF 585-614 (V600E)|BRAF585-614-V600E|BRAF 585-614 V600E NeoAg-mBRAF is a peptide consisting of aa 585-614 of the Braf protein with the BRAF V600E mutation, which may lead to cytotoxic T-lymphocyte mediated immune response against BRAF V600E-expressing tumor cells (NCI Drug Dictionary).
Poly ICLC Hiltonol Hiltonol (poly ICLC) is a synthetic double stranded RNA complex, which induces interferon production and stimulates anti-tumor immune response (PMID: 22126373).

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04364230 Phase Ib/II 6MHP vaccine + CDX-1140 + NeoAg-mBRAF + Poly ICLC Melanoma Vaccine Against Neoantigen and Shared Antigens by CD40 Activation and TLR Agonists In Patients With Melanoma (Mel66) Active, not recruiting USA 0


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