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Drug Name Letrozole
Trade Name Femara
Synonyms Letrozol
Drug Descriptions

Femara (letrozole) is an aromatase inhibitor, which inhibits estrogen synthesis, and is approved for postmenopausal women with hormone receptor positive breast cancer (FDA.gov).

DrugClasses Aromatase Inhibitor 3
CAS Registry Number 112809-51-5
NCIT ID C1527

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Anastrozole + Letrozole Abemaciclib Anastrozole Letrozole 0 1
Abemaciclib + ARTS-021 + Letrozole ARTS-021 Abemaciclib Letrozole 0 0
Abemaciclib + Durvalumab + Letrozole Abemaciclib Durvalumab Letrozole 0 1
Abemaciclib + Fulvestrant + Letrozole Abemaciclib Fulvestrant Letrozole 0 1
Abemaciclib + Goserelin + Letrozole Abemaciclib Goserelin Letrozole 0 1
Abemaciclib + Hydroxychloroquine + Letrozole Abemaciclib Hydroxychloroquine Letrozole 0 1
Abemaciclib + Letrozole Abemaciclib Letrozole 0 19
Abemaciclib + Letrozole + Leuprolide Abemaciclib Letrozole Leuprolide 0 1
Abemaciclib + Letrozole + LOXO-783 Abemaciclib LOXO-783 Letrozole 0 1
Abemaciclib + Letrozole + LY3023414 Abemaciclib LY3023414 Letrozole 0 1
Abemaciclib + Letrozole + LY3484356 Abemaciclib LY3484356 Letrozole 0 1
Abemaciclib + Letrozole + Metformin Abemaciclib Letrozole Metformin 0 1
Abemaciclib + Letrozole + Xentuzumab Abemaciclib Letrozole Xentuzumab 0 1
Ado-trastuzumab emtansine + Letrozole + Palbociclib Ado-trastuzumab emtansine Letrozole Palbociclib 0 1
Alisertib + Letrozole Alisertib Letrozole 0 1
Alpelisib + Letrozole Alpelisib Letrozole 3 6
Alpelisib + Letrozole + Ribociclib Alpelisib Letrozole Ribociclib 0 1
Amcenestrant + Letrozole Amcenestrant Letrozole 0 2
Anastrozole + Exemestane + Letrozole + Leuprolide + Tamoxifen Anastrozole Exemestane Letrozole Leuprolide Tamoxifen 0 0
Anastrozole + Letrozole Anastrozole Letrozole 0 2
ARTS-021 + Letrozole + Palbociclib ARTS-021 Letrozole Palbociclib 0 1
ARTS-021 + Letrozole + Ribociclib ARTS-021 Letrozole Ribociclib 0 0
Atezolizumab + Letrozole + Pelareorep Atezolizumab Letrozole Pelareorep 0 1
AZD4547 + Letrozole AZD4547 Letrozole 0 0
BGB-43395 + Letrozole BGB-43395 Letrozole 0 1
Buparlisib + Letrozole Buparlisib Letrozole 0 1
Buparlisib + Letrozole + Ribociclib Buparlisib Letrozole Ribociclib 0 1
Carboplatin + Docetaxel + Letrozole + Pertuzumab + Trastuzumab Carboplatin Docetaxel Letrozole Pertuzumab Trastuzumab 0 0
Carboplatin + Docetaxel + Letrozole + Trastuzumab Carboplatin Docetaxel Letrozole Trastuzumab 0 0
Carboplatin + Letrozole + Paclitaxel Carboplatin Letrozole Paclitaxel 0 1
Carotuximab + Everolimus + Letrozole Carotuximab Everolimus Letrozole 0 1
CB-103 + Letrozole CB-103 Letrozole 0 1
Copanlisib + Letrozole Copanlisib Letrozole 0 1
Copanlisib + Letrozole + Palbociclib Copanlisib Letrozole Palbociclib 0 1
Cyclophosphamide + Doxorubicin + Letrozole + Paclitaxel + Pertuzumab + Trastuzumab Cyclophosphamide Doxorubicin Letrozole Paclitaxel Pertuzumab Trastuzumab 0 0
Cyclophosphamide + Doxorubicin + Letrozole + Paclitaxel + Trastuzumab Cyclophosphamide Doxorubicin Letrozole Paclitaxel Trastuzumab 0 0
Cyclophosphamide + Letrozole + Maveropepimut-S Cyclophosphamide Letrozole Maveropepimut-S 0 1
Dalpiciclib + Letrozole + Pyrotinib Dalpiciclib Letrozole Pyrotinib 0 0
Defactinib + Letrozole + RO5126766 Defactinib Letrozole RO5126766 0 1
Durvalumab + Letrozole Durvalumab Letrozole 0 1
Entrectinib + Letrozole Entrectinib Letrozole 0 1
Everolimus + Letrozole Everolimus Letrozole 0 5
Everolimus + Letrozole + Metformin Everolimus Letrozole Metformin 0 0
Everolimus + Letrozole + Ribociclib Everolimus Letrozole Ribociclib 0 1
Everolimus + Letrozole + Trastuzumab Everolimus Letrozole Trastuzumab 0 1
FCN-437 + Letrozole FCN-437 Letrozole 0 0
Fulvestrant + Letrozole Fulvestrant Letrozole 0 0
Fulvestrant + Letrozole + Palbociclib Fulvestrant Letrozole Palbociclib 0 1
G1T38 + Letrozole G1T38 Letrozole 0 2
Goserelin + Letrozole Goserelin Letrozole 0 1
Goserelin + Letrozole + Palbociclib Goserelin Letrozole Palbociclib 0 2
Goserelin + Letrozole + Ribociclib Goserelin Letrozole Ribociclib 0 3
Hydroxychloroquine + Letrozole + Palbociclib Hydroxychloroquine Letrozole Palbociclib 0 1
Imatinib + Letrozole Imatinib Letrozole 1 0
Inavolisib + Letrozole Inavolisib Letrozole 0 1
Inavolisib + Letrozole + Palbociclib Inavolisib Letrozole Palbociclib 0 1
Lapatinib + Letrozole Lapatinib Letrozole 0 1
Lapatinib + Letrozole + Trastuzumab Lapatinib Letrozole Trastuzumab 0 0
Lenvatinib + Letrozole Lenvatinib Letrozole 0 0
Letrozole Letrozole 1 71
Letrozole + Leuprolide + Ribociclib Letrozole Leuprolide Ribociclib 0 1
Letrozole + Leuprolide + Tamoxifen Letrozole Leuprolide Tamoxifen 0 1
Letrozole + LOXO-783 LOXO-783 Letrozole 0 1
Letrozole + LY3023414 LY3023414 Letrozole 0 1
Letrozole + Maveropepimut-S Letrozole Maveropepimut-S 0 1
Letrozole + Megestrol acetate Letrozole Megestrol acetate 0 1
Letrozole + Narazaciclib Letrozole Narazaciclib 0 1
Letrozole + Neratinib Letrozole Neratinib 0 1
Letrozole + Neratinib + Trastuzumab Letrozole Neratinib Trastuzumab 0 1
Letrozole + Nintedanib Letrozole Nintedanib 0 0
Letrozole + Onapristone + Palbociclib Letrozole Onapristone Palbociclib 0 1
Letrozole + Paclitaxel + Pegylated liposomal doxorubicin + Tamoxifen Letrozole Paclitaxel Pegylated liposomal doxorubicin Tamoxifen 0 1
Letrozole + Palbociclib Letrozole Palbociclib 0 18
Letrozole + Palbociclib + Pembrolizumab Letrozole Palbociclib Pembrolizumab 0 1
Letrozole + Palbociclib + Pertuzumab + Trastuzumab Letrozole Palbociclib Pertuzumab Trastuzumab 0 1
Letrozole + Palbociclib + PF-06804103 Letrozole PF-06804103 Palbociclib 0 1
Letrozole + Palbociclib + PF-06952229 Letrozole PF-06952229 Palbociclib 0 1
Letrozole + Palbociclib + PF-07104091 Letrozole PF-07104091 Palbociclib 0 1
Letrozole + Palbociclib + PF-07248144 Letrozole PF-07248144 Palbociclib 0 1
Letrozole + Palbociclib + Trastuzumab Letrozole Palbociclib Trastuzumab 0 2
Letrozole + Palbociclib + Tucatinib Letrozole Palbociclib Tucatinib 0 1
Letrozole + Palbociclib + Venetoclax Letrozole Palbociclib Venetoclax 0 1
Letrozole + Patritumab deruxtecan Letrozole Patritumab deruxtecan 0 1
Letrozole + Pelareorep Letrozole Pelareorep 0 1
Letrozole + Pembrolizumab Letrozole Pembrolizumab 0 1
Letrozole + Pertuzumab + Ribociclib + Trastuzumab Letrozole Pertuzumab Ribociclib Trastuzumab 0 1
Letrozole + Pertuzumab + Trastuzumab Letrozole Pertuzumab Trastuzumab 0 0
Letrozole + Pertuzumab + Trastuzumab + Tucatinib Letrozole Pertuzumab Trastuzumab Tucatinib 0 1
Letrozole + PF-07104091 + PF-07220060 Letrozole PF-07104091 PF-07220060 0 1
Letrozole + PF-07220060 Letrozole PF-07220060 0 1
Letrozole + Ribociclib Letrozole Ribociclib 1 18
Letrozole + Seribantumab Letrozole Seribantumab 0 0
Letrozole + Simvastatin Letrozole Simvastatin 0 1
Letrozole + Talimogene laherparepvec Letrozole Talimogene laherparepvec 0 1
Letrozole + Tamoxifen Letrozole Tamoxifen 0 1
Letrozole + Tamoxifen + ZW25 Letrozole Tamoxifen ZW25 0 0
Letrozole + Taselisib Letrozole Taselisib 1 0
Letrozole + Trastuzumab Letrozole Trastuzumab 0 0
Letrozole + Vepdegestrant Letrozole Vepdegestrant 0 0
Letrozole + Zenocutuzumab Letrozole Zenocutuzumab 0 1
Letrozole + ZW25 Letrozole ZW25 0 1


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