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Drug Name Letrozole
Trade Name Femara
Synonyms Letrozol
Drug Descriptions

Femara (letrozole) is an aromatase inhibitor, which inhibits estrogen synthesis, and is approved for postmenopausal women with hormone receptor positive breast cancer (FDA.gov).

DrugClasses Aromatase Inhibitor 3
CAS Registry Number 112809-51-5
NCIT ID C1527

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Anastrozole + Letrozole Abemaciclib Anastrozole Letrozole 0 1
Abemaciclib + Durvalumab + Letrozole Abemaciclib Durvalumab Letrozole 0 1
Abemaciclib + Fulvestrant + Letrozole Abemaciclib Fulvestrant Letrozole 0 1
Abemaciclib + Goserelin + Letrozole Abemaciclib Goserelin Letrozole 0 1
Abemaciclib + Hydroxychloroquine + Letrozole Abemaciclib Hydroxychloroquine Letrozole 0 1
Abemaciclib + Letrozole Abemaciclib Letrozole 0 13
Abemaciclib + Letrozole + Leuprolide Abemaciclib Letrozole Leuprolide 0 1
Abemaciclib + Letrozole + LY3023414 Abemaciclib LY3023414 Letrozole 0 0
Abemaciclib + Letrozole + LY3484356 Abemaciclib LY3484356 Letrozole 0 1
Abemaciclib + Letrozole + Xentuzumab Abemaciclib Letrozole Xentuzumab 0 1
Ado-trastuzumab emtansine + Letrozole + Palbociclib Ado-trastuzumab emtansine Letrozole Palbociclib 0 1
Alpelisib + Letrozole Alpelisib Letrozole 3 5
Alpelisib + Letrozole + Ribociclib Alpelisib Letrozole Ribociclib 0 1
Anastrozole + Exemestane + Letrozole + Leuprolide + Tamoxifen Anastrozole Exemestane Letrozole Leuprolide Tamoxifen 0 0
Anastrozole + Letrozole Anastrozole Letrozole 0 2
Atezolizumab + Letrozole + Pelareorep Atezolizumab Letrozole Pelareorep 0 1
Buparlisib + Letrozole Buparlisib Letrozole 0 1
Buparlisib + Letrozole + Ribociclib Buparlisib Letrozole Ribociclib 0 1
Carboplatin + Docetaxel + Letrozole + Pertuzumab + Trastuzumab Carboplatin Docetaxel Letrozole Pertuzumab Trastuzumab 0 0
Carboplatin + Docetaxel + Letrozole + Trastuzumab Carboplatin Docetaxel Letrozole Trastuzumab 0 0
Carboplatin + Letrozole + Paclitaxel Carboplatin Letrozole Paclitaxel 0 1
Carotuximab + Everolimus + Letrozole Carotuximab Everolimus Letrozole 0 1
CB-103 + Letrozole CB-103 Letrozole 0 1
Copanlisib + Letrozole Copanlisib Letrozole 0 1
Copanlisib + Letrozole + Palbociclib Copanlisib Letrozole Palbociclib 0 1
Cyclophosphamide + Doxorubicin + Letrozole + Paclitaxel + Pertuzumab + Trastuzumab Cyclophosphamide Doxorubicin Letrozole Paclitaxel Pertuzumab Trastuzumab 0 0
Cyclophosphamide + Doxorubicin + Letrozole + Paclitaxel + Trastuzumab Cyclophosphamide Doxorubicin Letrozole Paclitaxel Trastuzumab 0 0
Cyclophosphamide + DPX-Survivac + Letrozole Cyclophosphamide DPX-Survivac Letrozole 0 1
DPX-Survivac + Letrozole DPX-Survivac Letrozole 0 1
Durvalumab + Letrozole Durvalumab Letrozole 0 1
Entrectinib + Letrozole Entrectinib Letrozole 0 1
Everolimus + Letrozole Everolimus Letrozole 0 5
Everolimus + Letrozole + Metformin Everolimus Letrozole Metformin 0 0
Everolimus + Letrozole + Ribociclib Everolimus Letrozole Ribociclib 0 1
Everolimus + Letrozole + Trastuzumab Everolimus Letrozole Trastuzumab 0 1
Fulvestrant + Letrozole Fulvestrant Letrozole 0 0
Fulvestrant + Letrozole + Palbociclib Fulvestrant Letrozole Palbociclib 0 1
GDC-0077 + Letrozole GDC-0077 Letrozole 0 1
GDC-0077 + Letrozole + Palbociclib GDC-0077 Letrozole Palbociclib 0 1
Goserelin + Letrozole Goserelin Letrozole 0 1
Goserelin + Letrozole + Palbociclib Goserelin Letrozole Palbociclib 0 2
Goserelin + Letrozole + Ribociclib Goserelin Letrozole Ribociclib 0 2
Hydroxychloroquine + Letrozole + Palbociclib Hydroxychloroquine Letrozole Palbociclib 0 1
Imatinib + Letrozole Imatinib Letrozole 1 0
Lapatinib + Letrozole Lapatinib Letrozole 0 1
Lapatinib + Letrozole + Trastuzumab Lapatinib Letrozole Trastuzumab 0 0
Letrozole Letrozole 1 46
Letrozole + Leuprolide + Tamoxifen Letrozole Leuprolide Tamoxifen 0 1
Letrozole + LY3023414 LY3023414 Letrozole 0 1
Letrozole + Onapristone + Palbociclib Letrozole Onapristone Palbociclib 0 1
Letrozole + Paclitaxel + Pegylated liposomal-doxorubicin + Tamoxifen Letrozole Paclitaxel Pegylated liposomal-doxorubicin Tamoxifen 0 1
Letrozole + Palbociclib Letrozole Palbociclib 0 14
Letrozole + Palbociclib + Pembrolizumab Letrozole Palbociclib Pembrolizumab 0 1
Letrozole + Palbociclib + Pertuzumab + Trastuzumab Letrozole Palbociclib Pertuzumab Trastuzumab 0 1
Letrozole + Palbociclib + PF-06804103 Letrozole PF-06804103 Palbociclib 0 1
Letrozole + Palbociclib + PF-06952229 Letrozole PF-06952229 Palbociclib 0 1
Letrozole + Palbociclib + PF-07104091 Letrozole PF-07104091 Palbociclib 0 1
Letrozole + Palbociclib + PF-07248144 Letrozole PF-07248144 Palbociclib 0 1
Letrozole + Palbociclib + Trastuzumab Letrozole Palbociclib Trastuzumab 0 2
Letrozole + Palbociclib + Tucatinib Letrozole Palbociclib Tucatinib 0 1
Letrozole + Pelareorep Letrozole Pelareorep 0 1
Letrozole + Pembrolizumab Letrozole Pembrolizumab 0 1
Letrozole + Pertuzumab + Ribociclib + Trastuzumab Letrozole Pertuzumab Ribociclib Trastuzumab 0 1
Letrozole + Pertuzumab + Trastuzumab + Tucatinib Letrozole Pertuzumab Trastuzumab Tucatinib 0 1
Letrozole + PF-07220060 Letrozole PF-07220060 0 1
Letrozole + Pyrotinib + SHR6390 Letrozole Pyrotinib SHR6390 0 0
Letrozole + Ribociclib Letrozole Ribociclib 1 14
Letrozole + SAR439859 Letrozole SAR439859 0 1
Letrozole + Seribantumab Letrozole Seribantumab 0 0
Letrozole + Talimogene laherparepvec Letrozole Talimogene laherparepvec 0 1
Letrozole + Tamoxifen + ZW25 Letrozole Tamoxifen ZW25 0 0
Letrozole + Taselisib Letrozole Taselisib 1 0
Letrozole + Trastuzumab Letrozole Trastuzumab 0 0
Letrozole + Zenocutuzumab Letrozole Zenocutuzumab 0 1
Letrozole + ZW25 Letrozole ZW25 0 1


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