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Drug Name Pyrotinib
Trade Name
Synonyms SHR-1258|SHR1258
Drug Descriptions

Pyrotinib is an irreversible dual inhibitor of EGFR and ERBB2 (HER2), which potentially leads to decreased growth of EGFR and/or HER2-positive tumor cells (PMID: 28115222, PMID: 30596880).

DrugClasses EGFR Inhibitor (Pan) 61 HER2 Inhibitor 41
CAS Registry Number 1269662-73-8
NCIT ID C111895

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Ado-trastuzumab emtansine + Exemestane + Pyrotinib + Zoledronic acid Ado-trastuzumab emtansine Exemestane Pyrotinib Zoledronic acid 0 0
Afatinib + Pyrotinib Afatinib Pyrotinib 0 0
Alpelisib + Pyrotinib Alpelisib Pyrotinib 0 0
Anlotinib + Nivolumab + Pyrotinib Anlotinib Nivolumab Pyrotinib 0 0
Bevacizumab + Pyrotinib Bevacizumab Pyrotinib 0 0
Bicalutamide + Pyrotinib Bicalutamide Pyrotinib 0 0
Capecitabine + Irinotecan + Pyrotinib Capecitabine Irinotecan Pyrotinib 0 0
Capecitabine + Paclitaxel + Pyrotinib + Trastuzumab Capecitabine Paclitaxel Pyrotinib Trastuzumab 0 0
Capecitabine + Pyrotinib Capecitabine Pyrotinib 0 0
Carboplatin + Docetaxel + Pyrotinib + Trastuzumab Carboplatin Docetaxel Pyrotinib Trastuzumab 0 0
Carboplatin + Paclitaxel + Pyrotinib Carboplatin Paclitaxel Pyrotinib 0 0
Dalpiciclib + Letrozole + Pyrotinib Dalpiciclib Letrozole Pyrotinib 0 0
Dalpiciclib + Pyrotinib Dalpiciclib Pyrotinib 0 0
Docetaxel + Pyrotinib Docetaxel Pyrotinib 0 0
Gefitinib + Pyrotinib Gefitinib Pyrotinib 0 0
Irinotecan + Oxaliplatin + Pyrotinib Irinotecan Oxaliplatin Pyrotinib 0 0
Irinotecan + Pyrotinib Irinotecan Pyrotinib 0 0
Lenvatinib + Pembrolizumab + Pyrotinib Lenvatinib Pembrolizumab Pyrotinib 0 0
Nab-paclitaxel + Pyrotinib Nab-paclitaxel Pyrotinib 0 0
Osimertinib + Pyrotinib Osimertinib Pyrotinib 0 0
Pyrotinib Pyrotinib 0 2
Pyrotinib + Rivoceranib Pyrotinib Rivoceranib 0 0
Pyrotinib + Trastuzumab Pyrotinib Trastuzumab 0 0
Pyrotinib + Vinorelbine Pyrotinib Vinorelbine 0 0


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