Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Pyrotinib
Trade Name
Synonyms SHR-1258|SHR1258
Drug Descriptions

Pyrotinib is an irreversible dual inhibitor of EGFR and ERBB2 (HER2), which potentially leads to decreased growth of EGFR and/or HER2-positive tumor cells (PMID: 28115222, PMID: 30596880).

DrugClasses EGFR Inhibitor (Pan) 55 HER2 Inhibitor 38
CAS Registry Number 1269662-73-8
NCIT ID C111895


  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"


  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Afatinib + Pyrotinib Afatinib Pyrotinib 0 0
Anlotinib + Nivolumab + Pyrotinib Anlotinib Nivolumab Pyrotinib 0 0
Bevacizumab + Pyrotinib Bevacizumab Pyrotinib 0 0
Bicalutamide + Pyrotinib Bicalutamide Pyrotinib 0 0
Capecitabine + Irinotecan + Pyrotinib Capecitabine Irinotecan Pyrotinib 0 0
Capecitabine + Pyrotinib Capecitabine Pyrotinib 0 0
Carboplatin + Docetaxel + Pyrotinib + Trastuzumab Carboplatin Docetaxel Pyrotinib Trastuzumab 0 0
Carboplatin + Paclitaxel + Pyrotinib Carboplatin Paclitaxel Pyrotinib 0 0
Gefitinib + Pyrotinib Gefitinib Pyrotinib 0 0
Irinotecan + Oxaliplatin + Pyrotinib Irinotecan Oxaliplatin Pyrotinib 0 0
Irinotecan + Pyrotinib Irinotecan Pyrotinib 0 0
Letrozole + Pyrotinib + SHR6390 Letrozole Pyrotinib SHR6390 0 0
Nab-paclitaxel + Pyrotinib Nab-paclitaxel Pyrotinib 0 0
Osimertinib + Pyrotinib Osimertinib Pyrotinib 0 0
Pyrotinib Pyrotinib 0 2
Pyrotinib + Rivoceranib Pyrotinib Rivoceranib 0 0
Pyrotinib + Trastuzumab Pyrotinib Trastuzumab 0 0
Pyrotinib + Vinorelbine Pyrotinib Vinorelbine 0 0

Additional content available in CKB BOOST