Drug Detail

Drug Name Irinotecan
Trade Name Camptosar
Synonyms CPT-11|Onivyde
Drug Descriptions

Camptosar (irinotecan) inhibits Topoisomerase-I activity, resulting in inhibition of DNA replication, and potentially leading to cell death (NCI Drug Dictionary). Camptosar (irinotecan) is indicated as a component of first-line therapy in combination with 5-fluorouracil and leucovorin for patients with metastatic or recurrent colorectal carcinoma (FDA.gov).

DrugClasses TOPO1 inhibitor 7

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Therapy Name Drugs Efficacy Evidence Clinical Trials
131I-MIBG + Irinotecan + Vincristine 131I-MIBG Irinotecan Vincristine 0 1
ABT-165 + Fluorouracil + Irinotecan + Leucovorin ABT-165 Fluorouracil Irinotecan Leucovorin 0 2
ABT-751 + Bevacizumab + Capecitabine + Irinotecan ABT-751 Bevacizumab Capecitabine Irinotecan 1 0
Adavosertib + Irinotecan Adavosertib Irinotecan 0 2
Aflibercept + Fluorouracil + Irinotecan + Leucovorin Aflibercept Fluorouracil Irinotecan Leucovorin 0 2
Alisertib + Irinotecan Alisertib Irinotecan 0 1
Alisertib + Irinotecan + Temozolomide Alisertib Irinotecan Temozolomide 2 1
AMG 232 + Irinotecan AMG 232 Irinotecan 1 0
Axitinib + Fluorouracil + Irinotecan + Leucovorin Axitinib Fluorouracil Irinotecan Leucovorin 1 0
AZ64 + Irinotecan + Temozolomide AZ64 Irinotecan Temozolomide 0 0
AZD7762 + Irinotecan AZD7762 Irinotecan 0 0
Bevacizumab + Cannabidiol + Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin Bevacizumab Cannabidiol Fluorouracil Irinotecan Leucovorin Oxaliplatin 0 1
Bevacizumab + Capecitabine + Fluorouracil + Irinotecan + Leucovorin Bevacizumab Capecitabine Fluorouracil Irinotecan Leucovorin 0 0
Bevacizumab + Cetuximab + Fluorouracil + Irinotecan + Leucovorin Bevacizumab Cetuximab Fluorouracil Irinotecan Leucovorin 1 0
Bevacizumab + Cetuximab + Irinotecan Bevacizumab Cetuximab Irinotecan 0 1
Bevacizumab + Cyclophosphamide + Doxorubicin + Etoposide + Ifosfamide + Irinotecan + Sorafenib + Temozolomide + Temsirolimus + Vincristine Bevacizumab Cyclophosphamide Doxorubicin Etoposide Ifosfamide Irinotecan Sorafenib Temozolomide Temsirolimus Vincristine 0 1
Bevacizumab + Fluorouracil + Irinotecan + Leucovorin Bevacizumab Fluorouracil Irinotecan Leucovorin 2 3
Bevacizumab + Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin Bevacizumab Fluorouracil Irinotecan Leucovorin Oxaliplatin 1 2
Bevacizumab + Fluorouracil + Irinotecan + Leucovorin + PCM-075 Bevacizumab Fluorouracil Irinotecan Leucovorin PCM-075 0 1
Bevacizumab + Fluorouracil + Irinotecan + Oxaliplatin Bevacizumab Fluorouracil Irinotecan Oxaliplatin 1 0
Bevacizumab + Irinotecan Bevacizumab Irinotecan 0 1
Bevacizumab + Irinotecan + Mebendazole Bevacizumab Irinotecan Mebendazole 0 1
Bevacizumab + Irinotecan + SGT-53 + Temozolomide Bevacizumab Irinotecan SGT-53 Temozolomide 0 1
Bevacizumab + Irinotecan + Temozolomide Bevacizumab Irinotecan Temozolomide 1 3
BGJ398 + Fluorouracil + Irinotecan + Oxaliplatin BGJ398 Fluorouracil Irinotecan Oxaliplatin 0 1
BI 885578 + Irinotecan BI 885578 Irinotecan 0 0
Binimetinib + Fluorouracil + Irinotecan + Leucovorin Binimetinib Fluorouracil Irinotecan Leucovorin 0 1
Binimetinib + Fluorouracil + Irinotecan + Leucovorin + Pembrolizumab Binimetinib Fluorouracil Irinotecan Leucovorin Pembrolizumab 0 1
BMS-813160 + Fluorouracil + Irinotecan + Leucovorin BMS-813160 Fluorouracil Irinotecan Leucovorin 0 1
Cabiralizumab + Fluorouracil + Irinotecan + Leucovorin + Nivolumab Cabiralizumab Fluorouracil Irinotecan Leucovorin Nivolumab 0 1
Capecitabine + Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin Capecitabine Fluorouracil Irinotecan Leucovorin Oxaliplatin 0 1
Carboplatin + Cisplatin + Doxorubicin + Irinotecan + Vincristine Carboplatin Cisplatin Doxorubicin Irinotecan Vincristine 0 1
Carboplatin + Doxorubicin + Irinotecan + Vincristine Carboplatin Doxorubicin Irinotecan Vincristine 0 0
CB-839 + Irinotecan + Panitumumab CB-839 Irinotecan Panitumumab 0 1
CCT244747 + Irinotecan CCT244747 Irinotecan 1 0
Cetuximab + Cisplatin + Irinotecan Cetuximab Cisplatin Irinotecan 1 0
Cetuximab + Floxuridine + Fluorouracil + Irinotecan Cetuximab Floxuridine Fluorouracil Irinotecan 0 0
Cetuximab + Fluorouracil + Irinotecan + Leucovorin Cetuximab Fluorouracil Irinotecan Leucovorin 7 5
Cetuximab + Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin Cetuximab Fluorouracil Irinotecan Leucovorin Oxaliplatin 2 1
Cetuximab + Irinotecan Cetuximab Irinotecan 4 5
Cetuximab + Irinotecan + Oxaliplatin Cetuximab Irinotecan Oxaliplatin 0 1
Cetuximab + Irinotecan + Ramucirumab Cetuximab Irinotecan Ramucirumab 0 1
Cetuximab + Irinotecan + Utomilumab Cetuximab Irinotecan Utomilumab 0 1
Cetuximab + Irinotecan + Vemurafenib Cetuximab Irinotecan Vemurafenib 3 2
CHIR-124 + Irinotecan CHIR-124 Irinotecan 1 0
Cisplatin + Irinotecan Cisplatin Irinotecan 1 1
CPI-613 + Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin CPI-613 Fluorouracil Irinotecan Leucovorin Oxaliplatin 0 1
CVX-241 + Irinotecan CVX-241 Irinotecan 1 0
Dexamethasone + Floxuridine + Fluorouracil + Irinotecan + Leucovorin + Panitumumab Dexamethasone Floxuridine Fluorouracil Irinotecan Leucovorin Panitumumab 0 1
Docetaxel + Irinotecan Docetaxel Irinotecan 0 1
Docetaxel + Irinotecan + Paclitaxel Docetaxel Irinotecan Paclitaxel 0 2
Docetaxel + Irinotecan + Pemetrexed Docetaxel Irinotecan Pemetrexed 0 1
DS-3201b + Irinotecan DS-3201b Irinotecan 0 1
FANG vaccine + Irinotecan + Temozolomide FANG vaccine Irinotecan Temozolomide 0 1
Floxuridine + Fluorouracil + Irinotecan Floxuridine Fluorouracil Irinotecan 0 0
Floxuridine + Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin + Panitumumab Floxuridine Fluorouracil Irinotecan Leucovorin Oxaliplatin Panitumumab 0 1
Fluorouracil + Irinotecan + Lapatinib + Leucovorin Fluorouracil Irinotecan Lapatinib Leucovorin 0 1
Fluorouracil + Irinotecan + Leucovorin Fluorouracil Irinotecan Leucovorin 0 22
Fluorouracil + Irinotecan + Leucovorin + Losartan + Nivolumab + Oxaliplatin Fluorouracil Irinotecan Leucovorin Losartan Nivolumab Oxaliplatin 0 1
Fluorouracil + Irinotecan + Leucovorin + Losartan + Oxaliplatin Fluorouracil Irinotecan Leucovorin Losartan Oxaliplatin 0 1
Fluorouracil + Irinotecan + Leucovorin + MM-151 Fluorouracil Irinotecan Leucovorin MM-151 0 1
Fluorouracil + Irinotecan + Leucovorin + Nivolumab Fluorouracil Irinotecan Leucovorin Nivolumab 0 1
Fluorouracil + Irinotecan + Leucovorin + Nivolumab + Oxaliplatin Fluorouracil Irinotecan Leucovorin Nivolumab Oxaliplatin 0 2
Fluorouracil + Irinotecan + Leucovorin + OMP-305B83 Fluorouracil Irinotecan Leucovorin Navicixizumab 0 1
Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin Fluorouracil Irinotecan Leucovorin Oxaliplatin 0 7
Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin + Panitumumab Fluorouracil Irinotecan Leucovorin Oxaliplatin Panitumumab 2 0
Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin + Saridegib Fluorouracil Irinotecan Leucovorin Oxaliplatin Saridegib 0 1
Fluorouracil + Irinotecan + Leucovorin + Panitumumab Fluorouracil Irinotecan Leucovorin Panitumumab 3 0
Fluorouracil + Irinotecan + Leucovorin + Pembrolizumab Fluorouracil Irinotecan Leucovorin Pembrolizumab 0 1
Fluorouracil + Irinotecan + Leucovorin + Ramucirumab Fluorouracil Irinotecan Leucovorin Ramucirumab 2 0
Fluorouracil + Irinotecan + Leucovorin + Rucaparib Fluorouracil Irinotecan Leucovorin Rucaparib 0 1
Fluorouracil + Irinotecan + Leucovorin + Simtuzumab Fluorouracil Irinotecan Leucovorin Simtuzumab 1 0
Fluorouracil + Irinotecan + Leucovorin + SYM004 Fluorouracil Irinotecan Leucovorin SYM004 0 1
Fluorouracil + Irinotecan + Leucovorin + TRK-950 Fluorouracil Irinotecan Leucovorin TRK-950 0 1
Fluorouracil + Irinotecan + Oxaliplatin + Panitumumab Fluorouracil Irinotecan Oxaliplatin Panitumumab 5 0
GA201 + Irinotecan GA201 Irinotecan 0 0
Gedatolisib + Irinotecan Gedatolisib Irinotecan 1 0
GNF-4256 + Irinotecan + Temozolomide GNF-4256 Irinotecan Temozolomide 0 0
Guadecitabine + Irinotecan Guadecitabine Irinotecan 0 1
Iniparib + Irinotecan Iniparib Irinotecan 0 1
Irinotecan Irinotecan 4 19
Irinotecan + KD018 Irinotecan KD018 0 0
Irinotecan + Lurbinectedin Irinotecan Lurbinectedin 0 0
Irinotecan + MLN4924 + Temozolomide Irinotecan MLN4924 Temozolomide 0 1
Irinotecan + Nab-Rapamycin + Temozolomide Irinotecan Nab-Rapamycin Temozolomide 0 1
Irinotecan + Naxitamab + Sargramostim + Temozolomide Irinotecan Naxitamab Sargramostim Temozolomide 0 1
Irinotecan + Nimotuzumab Irinotecan Nimotuzumab 1 0
Irinotecan + Niraparib Irinotecan Niraparib 0 0
Irinotecan + Olaparib Irinotecan Olaparib 0 0
Irinotecan + Palbociclib + Temozolomide Irinotecan Palbociclib Temozolomide 0 1
Irinotecan + Panitumumab Irinotecan Panitumumab 3 0
Irinotecan + Panitumumab + Vemurafenib Irinotecan Panitumumab Vemurafenib 2 0
Irinotecan + Pazopanib + Temozolomide Irinotecan Pazopanib Temozolomide 0 1
Irinotecan + Pembrolizumab Irinotecan Pembrolizumab 0 1
Irinotecan + Ramucirumab Irinotecan Ramucirumab 0 1
Irinotecan + Reolysin Irinotecan Reolysin 1 0
Irinotecan + RG7386 Irinotecan RG7386 0 0
Irinotecan + RRx-001 Irinotecan RRx-001 0 1
Irinotecan + Rucaparib Irinotecan Rucaparib 0 1
Irinotecan + Selinexor Irinotecan Selinexor 0 1
Irinotecan + Selumetinib Irinotecan Selumetinib 1 0
Irinotecan + Sirolimus + Sunitinib + Temozolomide Irinotecan Sirolimus Sunitinib Temozolomide 1 0
Irinotecan + Sorafenib Irinotecan Sorafenib 0 2
Irinotecan + Talazoparib Irinotecan Talazoparib 0 2
Irinotecan + Temozolomide Irinotecan Temozolomide 0 3
Irinotecan + Temozolomide + Vincristine Irinotecan Temozolomide Vincristine 0 1
Irinotecan + Temsirolimus + Vincristine Irinotecan Temsirolimus Vincristine 0 1
Irinotecan + Veliparib Irinotecan Veliparib 6 1
Irinotecan + Vincristine Irinotecan Vincristine 0 1
Irinotecan + VX-970 Irinotecan VX-970 1 2