Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Irinotecan
Trade Name Camptosar
Synonyms CPT-11|Onivyde
Drug Descriptions

Camptosar (irinotecan) inhibits Topoisomerase-I activity, resulting in inhibition of DNA replication, and potentially leading to cell death and is indicated as a component of first-line therapy in combination with 5-fluorouracil and leucovorin for patients with metastatic or recurrent colorectal carcinoma (FDA.gov).

DrugClasses TOPO1 inhibitor 9
CAS Registry Number 136572-09-3
NCIT ID C1381

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
131I-MIBG + Irinotecan + Vincristine Sulfate 131I-MIBG Irinotecan Vincristine Sulfate 0 1
9-ING-41 + Irinotecan 9-ING-41 Irinotecan 0 2
ABBV-181 + ABBV-927 + Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin ABBV-181 ABBV-927 Fluorouracil Irinotecan Leucovorin Oxaliplatin 0 1
ABBV-927 + Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin ABBV-927 Fluorouracil Irinotecan Leucovorin Oxaliplatin 0 1
Abemaciclib + Irinotecan + Temozolomide Abemaciclib Irinotecan Temozolomide 0 1
ABT-165 + Fluorouracil + Irinotecan + Leucovorin ABT-165 Fluorouracil Irinotecan Leucovorin 0 2
ABT-751 + Bevacizumab + Capecitabine + Irinotecan ABT-751 Bevacizumab Capecitabine Irinotecan 0 0
ABTL0812 + Fluorouracil + Irinotecan + Oxaliplatin ABTL0812 Fluorouracil Irinotecan Oxaliplatin 0 1
Adavosertib + Irinotecan Adavosertib Irinotecan 0 2
Aflibercept + Fluorouracil + Irinotecan + Leucovorin Aflibercept Fluorouracil Irinotecan Leucovorin 0 4
Alisertib + Irinotecan Alisertib Irinotecan 0 1
Alisertib + Irinotecan + Temozolomide Alisertib Irinotecan Temozolomide 0 1
Atezolizumab + Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin + RO7198457 Atezolizumab Fluorouracil Irinotecan Leucovorin Oxaliplatin RO7198457 0 1
Atezolizumab + Irinotecan + Temozolomide + Vincristine Sulfate Atezolizumab Irinotecan Temozolomide Vincristine Sulfate 0 1
Avelumab + Cetuximab + Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin Avelumab Cetuximab Fluorouracil Irinotecan Leucovorin Oxaliplatin 0 1
Avelumab + Cetuximab + Irinotecan Avelumab Cetuximab Irinotecan 0 1
Axitinib + Fluorouracil + Irinotecan + Leucovorin Axitinib Fluorouracil Irinotecan Leucovorin 0 0
AZ64 + Irinotecan + Temozolomide AZ64 Irinotecan Temozolomide 0 0
AZD7762 + Irinotecan AZD7762 Irinotecan 0 0
BAY1895344 + Fluorouracil + Irinotecan + Leucovorin BAY1895344 Fluorouracil Irinotecan Leucovorin 0 1
BAY1895344 + Irinotecan BAY1895344 Irinotecan 0 1
Berzosertib + Irinotecan Berzosertib Irinotecan 0 3
Bevacizumab + Cannabidiol + Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin Bevacizumab Cannabidiol Fluorouracil Irinotecan Leucovorin Oxaliplatin 0 1
Bevacizumab + Capecitabine + Fluorouracil + Irinotecan + Leucovorin Bevacizumab Capecitabine Fluorouracil Irinotecan Leucovorin 0 0
Bevacizumab + Cetuximab + Fluorouracil + Irinotecan + Leucovorin Bevacizumab Cetuximab Fluorouracil Irinotecan Leucovorin 0 0
Bevacizumab + Cetuximab + Irinotecan Bevacizumab Cetuximab Irinotecan 0 1
Bevacizumab + Cholecalciferol + Fluorouracil + Irinotecan + Leucovorin Bevacizumab Cholecalciferol Fluorouracil Irinotecan Leucovorin 0 1
Bevacizumab + Cyclophosphamide + Doxorubicin + Etoposide + Ifosfamide + Irinotecan + Sorafenib + Temozolomide + Temsirolimus + Vincristine Sulfate Bevacizumab Cyclophosphamide Doxorubicin Etoposide Ifosfamide Irinotecan Sorafenib Temozolomide Temsirolimus Vincristine Sulfate 0 1
Bevacizumab + Fluorouracil + IGM-8444 + Irinotecan + Leucovorin Bevacizumab Fluorouracil IGM-8444 Irinotecan Leucovorin 0 1
Bevacizumab + Fluorouracil + Irinotecan + Leucovorin Bevacizumab Fluorouracil Irinotecan Leucovorin 0 9
Bevacizumab + Fluorouracil + Irinotecan + Leucovorin + Napabucasin Bevacizumab Fluorouracil Irinotecan Leucovorin Napabucasin 0 0
Bevacizumab + Fluorouracil + Irinotecan + Leucovorin + Nivolumab + Oxaliplatin Bevacizumab Fluorouracil Irinotecan Leucovorin Nivolumab Oxaliplatin 0 1
Bevacizumab + Fluorouracil + Irinotecan + Leucovorin + Onvansertib Bevacizumab Fluorouracil Irinotecan Leucovorin Onvansertib 0 1
Bevacizumab + Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin Bevacizumab Fluorouracil Irinotecan Leucovorin Oxaliplatin 0 9
Bevacizumab + Fluorouracil + Irinotecan + Leucovorin + Pelareorep Bevacizumab Fluorouracil Irinotecan Leucovorin Pelareorep 0 0
Bevacizumab + Fluorouracil + Irinotecan + Leucovorin + RGX202 Bevacizumab Fluorouracil Irinotecan Leucovorin RGX202 0 1
Bevacizumab + Fluorouracil + Irinotecan + Leucovorin + Temozolomide Bevacizumab Fluorouracil Irinotecan Leucovorin Temozolomide 0 1
Bevacizumab + Fluorouracil + Irinotecan + Leucovorin + XOMA 052 Bevacizumab Fluorouracil Irinotecan Leucovorin XOMA 052 0 1
Bevacizumab + Fluorouracil + Irinotecan + Oxaliplatin Bevacizumab Fluorouracil Irinotecan Oxaliplatin 0 0
Bevacizumab + Irinotecan Bevacizumab Irinotecan 0 1
Bevacizumab + Irinotecan + Mebendazole Bevacizumab Irinotecan Mebendazole 0 1
Bevacizumab + Irinotecan + SGT-53 + Temozolomide Bevacizumab Irinotecan SGT-53 Temozolomide 0 1
Bevacizumab + Irinotecan + Temozolomide Bevacizumab Irinotecan Temozolomide 0 4
Bevacizumab + Irinotecan + Trifluridine-tipiracil hydrochloride Bevacizumab Irinotecan Trifluridine-tipiracil hydrochloride 0 1
BI 885578 + Irinotecan BI 885578 Irinotecan 0 0
Binimetinib + Fluorouracil + Irinotecan + Leucovorin Binimetinib Fluorouracil Irinotecan Leucovorin 0 1
Binimetinib + Fluorouracil + Irinotecan + Leucovorin + Pembrolizumab Binimetinib Fluorouracil Irinotecan Leucovorin Pembrolizumab 0 1
BMS-813160 + Fluorouracil + Irinotecan + Leucovorin BMS-813160 Fluorouracil Irinotecan Leucovorin 0 1
Cabiralizumab + Fluorouracil + Irinotecan + Leucovorin + Nivolumab Cabiralizumab Fluorouracil Irinotecan Leucovorin Nivolumab 0 1
Capecitabine + Cisplatin + Gemcitabine + Irinotecan + Nab-paclitaxel Capecitabine Cisplatin Gemcitabine Irinotecan Nab-paclitaxel 0 1
Capecitabine + Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin Capecitabine Fluorouracil Irinotecan Leucovorin Oxaliplatin 0 1
Carboplatin + Cisplatin + Doxorubicin + Irinotecan + Vincristine Sulfate Carboplatin Cisplatin Doxorubicin Irinotecan Vincristine Sulfate 0 1
Carboplatin + Doxorubicin + Irinotecan + Vincristine Sulfate Carboplatin Doxorubicin Irinotecan Vincristine Sulfate 0 0
CCT244747 + Irinotecan CCT244747 Irinotecan 0 0
Cefixime + Irinotecan + Temozolomide + Vincristine Sulfate Cefixime Irinotecan Temozolomide Vincristine Sulfate 0 1
Cefixime + Irinotecan + Temozolomide + Vincristine Sulfate + Vorinostat Cefixime Irinotecan Temozolomide Vincristine Sulfate Vorinostat 0 1
Cetuximab + Cisplatin + Irinotecan Cetuximab Cisplatin Irinotecan 0 0
Cetuximab + Encorafenib + Fluorouracil + Irinotecan + Leucovorin Cetuximab Encorafenib Fluorouracil Irinotecan Leucovorin 0 1
Cetuximab + Floxuridine + Fluorouracil + Irinotecan Cetuximab Floxuridine Fluorouracil Irinotecan 1 0
Cetuximab + Fluorouracil + Irinotecan + Leucovorin Cetuximab Fluorouracil Irinotecan Leucovorin 2 11
Cetuximab + Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin Cetuximab Fluorouracil Irinotecan Leucovorin Oxaliplatin 0 2
Cetuximab + Irinotecan Cetuximab Irinotecan 3 9
Cetuximab + Irinotecan + Oxaliplatin Cetuximab Irinotecan Oxaliplatin 0 1
Cetuximab + Irinotecan + Ramucirumab Cetuximab Irinotecan Ramucirumab 0 1
Cetuximab + Irinotecan + Utomilumab Cetuximab Irinotecan Utomilumab 0 1
Cetuximab + Irinotecan + Vemurafenib Cetuximab Irinotecan Vemurafenib 2 2
CHIR-124 + Irinotecan CHIR-124 Irinotecan 1 0
Cisplatin + Irinotecan Cisplatin Irinotecan 1 1
Cisplatin + Irinotecan + Nimotuzumab Cisplatin Irinotecan Nimotuzumab 0 0
CPI-0209 + Irinotecan CPI-0209 Irinotecan 0 1
CPI-613 + Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin CPI-613 Fluorouracil Irinotecan Leucovorin Oxaliplatin 0 3
CVX-241 + Irinotecan CVX-241 Irinotecan 0 0
Dasatinib + Irinotecan + Nab-Rapamycin + Temozolomide Dasatinib Irinotecan Nab-Rapamycin Temozolomide 0 0
Dasatinib + Irinotecan + Sirolimus + Temozolomide Dasatinib Irinotecan Sirolimus Temozolomide 0 1
Dexamethasone + Floxuridine + Fluorouracil + Irinotecan + Leucovorin + Panitumumab Dexamethasone Floxuridine Fluorouracil Irinotecan Leucovorin Panitumumab 0 1
Dinutuximab + Irinotecan + Isotretinoin + Sargramostim + Temozolomide Dinutuximab Irinotecan Isotretinoin Sargramostim Temozolomide 0 1
Docetaxel + Irinotecan Docetaxel Irinotecan 0 1
Docetaxel + Irinotecan + Paclitaxel Docetaxel Irinotecan Paclitaxel 0 2
Docetaxel + Irinotecan + Pemetrexed Disodium Docetaxel Irinotecan Pemetrexed Disodium 0 1
DS-3201b + Irinotecan DS-3201b Irinotecan 0 1
Durvalumab + Fluorouracil + Irinotecan + Leucovorin Durvalumab Fluorouracil Irinotecan Leucovorin 0 1
Durvalumab + Fluorouracil + Irinotecan + Leucovorin + Tremelimumab Durvalumab Fluorouracil Irinotecan Leucovorin Tremelimumab 0 1
Eryaspase + Fluorouracil + Irinotecan + Leucovorin Eryaspase Fluorouracil Irinotecan Leucovorin 0 1
Eryaspase + Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin Eryaspase Fluorouracil Irinotecan Leucovorin Oxaliplatin 0 1
FANG vaccine + Irinotecan + Temozolomide FANG vaccine Irinotecan Temozolomide 0 2
Floxuridine + Fluorouracil + Irinotecan Floxuridine Fluorouracil Irinotecan 0 0
Floxuridine + Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin + Panitumumab Floxuridine Fluorouracil Irinotecan Leucovorin Oxaliplatin Panitumumab 0 1
Fluorouracil + IGM-8444 + Irinotecan + Leucovorin Fluorouracil IGM-8444 Irinotecan Leucovorin 0 1
Fluorouracil + Infigratinib + Irinotecan + Oxaliplatin Fluorouracil Infigratinib Irinotecan Oxaliplatin 0 1
Fluorouracil + Irinotecan + JNJ-64457107 + Leucovorin + Oxaliplatin Fluorouracil Irinotecan JNJ-64457107 Leucovorin Oxaliplatin 0 1
Fluorouracil + Irinotecan + Lapatinib + Leucovorin Fluorouracil Irinotecan Lapatinib Leucovorin 0 1
Fluorouracil + Irinotecan + Leucovorin Fluorouracil Irinotecan Leucovorin 0 32
Fluorouracil + Irinotecan + Leucovorin + Losartan + Nivolumab + Oxaliplatin Fluorouracil Irinotecan Leucovorin Losartan Nivolumab Oxaliplatin 0 1
Fluorouracil + Irinotecan + Leucovorin + Losartan + Oxaliplatin Fluorouracil Irinotecan Leucovorin Losartan Oxaliplatin 0 1
Fluorouracil + Irinotecan + Leucovorin + MM-151 Fluorouracil Irinotecan Leucovorin MM-151 0 1
Fluorouracil + Irinotecan + Leucovorin + Napabucasin Fluorouracil Irinotecan Leucovorin Napabucasin 0 1
Fluorouracil + Irinotecan + Leucovorin + Navicixizumab Fluorouracil Irinotecan Leucovorin Navicixizumab 0 1
Fluorouracil + Irinotecan + Leucovorin + Nidanilimab + Oxaliplatin Fluorouracil Irinotecan Leucovorin Nidanilimab Oxaliplatin 0 1
Fluorouracil + Irinotecan + Leucovorin + Nivolumab Fluorouracil Irinotecan Leucovorin Nivolumab 0 1
Fluorouracil + Irinotecan + Leucovorin + Nivolumab + Oxaliplatin Fluorouracil Irinotecan Leucovorin Nivolumab Oxaliplatin 0 2
Fluorouracil + Irinotecan + Leucovorin + NKR-2 cells Fluorouracil Irinotecan Leucovorin NKR-2 cells 0 1
Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin Fluorouracil Irinotecan Leucovorin Oxaliplatin 0 9
Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin + Panitumumab Fluorouracil Irinotecan Leucovorin Oxaliplatin Panitumumab 0 1
Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin + Saridegib Fluorouracil Irinotecan Leucovorin Oxaliplatin Saridegib 0 1
Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin + unspecified EGFR antibody Fluorouracil Irinotecan Leucovorin Oxaliplatin unspecified EGFR antibody 0 1
Fluorouracil + Irinotecan + Leucovorin + Panitumumab Fluorouracil Irinotecan Leucovorin Panitumumab 0 5
Fluorouracil + Irinotecan + Leucovorin + Pelareorep Fluorouracil Irinotecan Leucovorin Pelareorep 0 0
Fluorouracil + Irinotecan + Leucovorin + Pembrolizumab Fluorouracil Irinotecan Leucovorin Pembrolizumab 0 1
Fluorouracil + Irinotecan + Leucovorin + Ramucirumab Fluorouracil Irinotecan Leucovorin Ramucirumab 0 1
Fluorouracil + Irinotecan + Leucovorin + RGX202 Fluorouracil Irinotecan Leucovorin RGX202 0 1
Fluorouracil + Irinotecan + Leucovorin + Rucaparib Fluorouracil Irinotecan Leucovorin Rucaparib 0 0
Fluorouracil + Irinotecan + Leucovorin + Simtuzumab Fluorouracil Irinotecan Leucovorin Simtuzumab 0 0
Fluorouracil + Irinotecan + Leucovorin + SYM004 Fluorouracil Irinotecan Leucovorin SYM004 0 1
Fluorouracil + Irinotecan + Leucovorin + TRK-950 Fluorouracil Irinotecan Leucovorin TRK-950 0 1
Fluorouracil + Irinotecan + Leucovorin + Veliparib Fluorouracil Irinotecan Leucovorin Veliparib 0 1
Fluorouracil + Irinotecan + Oxaliplatin Fluorouracil Irinotecan Oxaliplatin 0 1
Fluorouracil + Irinotecan + Oxaliplatin + Panitumumab Fluorouracil Irinotecan Oxaliplatin Panitumumab 0 0
Fluorouracil + Irinotecan + Oxaliplatin + siG12D-LODER Fluorouracil Irinotecan Oxaliplatin siG12D-LODER 0 0
Gedatolisib + Irinotecan Gedatolisib Irinotecan 0 0
GNF-4256 + Irinotecan + Temozolomide GNF-4256 Irinotecan Temozolomide 0 0
Guadecitabine + Irinotecan Guadecitabine Irinotecan 0 1
HX008 + Irinotecan HX008 Irinotecan 0 0
Imgatuzumab + Irinotecan Imgatuzumab Irinotecan 0 0
Iniparib + Irinotecan Iniparib Irinotecan 0 1
Irinotecan Irinotecan 1 23
Irinotecan + KRT-232 Irinotecan KRT-232 0 0
Irinotecan + KU-59403 Irinotecan KU-59403 0 0
Irinotecan + Lurbinectedin Irinotecan Lurbinectedin 0 1
Irinotecan + Minnelide Irinotecan Minnelide 0 0
Irinotecan + MLN4924 + Temozolomide Irinotecan MLN4924 Temozolomide 0 1
Irinotecan + Nab-Rapamycin + Temozolomide Irinotecan Nab-Rapamycin Temozolomide 0 1
Irinotecan + Naxitamab + Sargramostim + Temozolomide Irinotecan Naxitamab Sargramostim Temozolomide 0 2
Irinotecan + Nimotuzumab Irinotecan Nimotuzumab 0 0
Irinotecan + Niraparib Irinotecan Niraparib 0 0
Irinotecan + Nivolumab Irinotecan Nivolumab 0 1
Irinotecan + Olaparib Irinotecan Olaparib 0 1
Irinotecan + Palbociclib + Temozolomide Irinotecan Palbociclib Temozolomide 0 1
Irinotecan + Panitumumab Irinotecan Panitumumab 1 3
Irinotecan + Panitumumab + Telaglenastat Irinotecan Panitumumab Telaglenastat 0 1
Irinotecan + Panitumumab + Vemurafenib Irinotecan Panitumumab Vemurafenib 0 0
Irinotecan + Pazopanib + Temozolomide Irinotecan Pazopanib Temozolomide 0 1
Irinotecan + Pelareorep Irinotecan Pelareorep 0 0
Irinotecan + Pembrolizumab Irinotecan Pembrolizumab 0 1
Irinotecan + Prexasertib + Temozolomide Irinotecan Prexasertib Temozolomide 0 1
Irinotecan + Pyrotinib Irinotecan Pyrotinib 0 0
Irinotecan + Ramucirumab Irinotecan Ramucirumab 0 1
Irinotecan + Regorafenib Irinotecan Regorafenib 0 1
Irinotecan + Repotrectinib + Temozolomide Irinotecan Repotrectinib Temozolomide 0 1
Irinotecan + RG7386 Irinotecan RG7386 0 0
Irinotecan + RRx-001 Irinotecan RRx-001 0 1
Irinotecan + RRx-001 + Temozolomide Irinotecan RRx-001 Temozolomide 0 1
Irinotecan + Rucaparib Irinotecan Rucaparib 0 1
Irinotecan + Selinexor Irinotecan Selinexor 0 1
Irinotecan + Selumetinib Irinotecan Selumetinib 0 0
Irinotecan + Sirolimus + Sunitinib + Temozolomide Irinotecan Sirolimus Sunitinib Temozolomide 0 0
Irinotecan + Sorafenib Irinotecan Sorafenib 0 2
Irinotecan + SR-4835 Irinotecan SR-4835 0 0
Irinotecan + Talazoparib Irinotecan Talazoparib 0 3
Irinotecan + Temozolomide Irinotecan Temozolomide 0 5
Irinotecan + Temozolomide + Vincristine Sulfate Irinotecan Temozolomide Vincristine Sulfate 0 1
Irinotecan + Temsirolimus + Vincristine Sulfate Irinotecan Temsirolimus Vincristine Sulfate 0 1
Irinotecan + Trabectedin Irinotecan Trabectedin 0 1
Irinotecan + Trifluridine-tipiracil hydrochloride Irinotecan Trifluridine-tipiracil hydrochloride 0 1
Irinotecan + Veliparib Irinotecan Veliparib 1 1
Irinotecan + Vemurafenib Irinotecan Vemurafenib 1 0
Irinotecan + Venetoclax Irinotecan Venetoclax 0 1
Irinotecan + Vincristine Sulfate Irinotecan Vincristine Sulfate 0 1
Irinotecan + VLX600 Irinotecan VLX600 0 0
Irinotecan + VX-803 Irinotecan VX-803 0 0
Irinotecan + YIV-906 Irinotecan YIV-906 0 0


Additional content available in CKB BOOST