Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Vemurafenib
Trade Name Zelboraf
Synonyms RO5185426|PLX4032
Drug Descriptions

Zelboraf (vemurafenib) inhibits BRAF V600E, wild-type BRAF, ARAF, and CRAF (PMID: 20179705), which may result in an inhibition of the MAPK signaling pathway resulting in a reduction of tumor cell proliferation (PMID: 20823850). Zelboraf (vemurafenib) is FDA approved for BRAF V600E-mutant melanoma and for BRAF V600-positive Erdheim-Chester disease (FDA.gov).

DrugClasses RAF Inhibitor (Pan) 27
CAS Registry Number 918504-65-1
NCIT ID C64768

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
A-1210477 + Cobimetinib + Vemurafenib A-1210477 Cobimetinib Vemurafenib 0 0
A-1210477 + Vemurafenib A-1210477 Vemurafenib 0 0
Acitretin + Vemurafenib Acitretin Vemurafenib 0 1
Aldesleukin + Alpha 2 Interferon + Vemurafenib Aldesleukin Alpha 2 Interferon Vemurafenib 0 1
Aldesleukin + Vemurafenib Aldesleukin Vemurafenib 0 2
ASTX029 + Vemurafenib ASTX029 Vemurafenib 1 0
Atezolizumab + Cobimetinib + Vemurafenib Atezolizumab Cobimetinib Vemurafenib 5 7
Atezolizumab + Vemurafenib Atezolizumab Vemurafenib 1 1
Axitinib + Vemurafenib Axitinib Vemurafenib 1 0
Bemcentinib + Vemurafenib Bemcentinib Vemurafenib 0 0
Bevacizumab + Capecitabine + Vemurafenib Bevacizumab Capecitabine Vemurafenib 1 0
Bevacizumab + Vemurafenib Bevacizumab Vemurafenib 1 0
Bosutinib + Vemurafenib Bosutinib Vemurafenib 1 0
Buparlisib + Vemurafenib Buparlisib Vemurafenib 1 1
Cabozantinib + Vemurafenib Cabozantinib Vemurafenib 0 1
Capecitabine + Vemurafenib Capecitabine Vemurafenib 1 0
Carboplatin + Paclitaxel + Vemurafenib Carboplatin Paclitaxel Vemurafenib 0 1
CDX-3379 + Vemurafenib CDX-3379 Vemurafenib 0 2
Celecoxib + Gefitinib + Trametinib + Vemurafenib Celecoxib Gefitinib Trametinib Vemurafenib 1 0
Celecoxib + Trametinib + Vemurafenib Celecoxib Trametinib Vemurafenib 1 0
Celecoxib + Vemurafenib Celecoxib Vemurafenib 1 0
Cetuximab + Fluorouracil + Leucovorin + Vemurafenib Cetuximab Fluorouracil Leucovorin Vemurafenib 2 0
Cetuximab + Irinotecan + Vemurafenib Cetuximab Irinotecan Vemurafenib 3 2
Cetuximab + Selumetinib + Vemurafenib Cetuximab Selumetinib Vemurafenib 0 0
Cetuximab + Vemurafenib Cetuximab Vemurafenib 10 0
Cobimetinib + LY3022855 + Vemurafenib Cobimetinib LY3022855 Vemurafenib 0 1
Cobimetinib + Onartuzumab + Vemurafenib Cobimetinib Onartuzumab Vemurafenib 0 1
Cobimetinib + Pembrolizumab + Vemurafenib Cobimetinib Pembrolizumab Vemurafenib 2 1
Cobimetinib + Vemurafenib Cobimetinib Vemurafenib 49 14
Cobimetinib + Vemurafenib + XL888 Cobimetinib Vemurafenib XL888 0 1
Copanlisib + Vemurafenib Copanlisib Vemurafenib 0 1
CPI-455 + Vemurafenib CPI-455 Vemurafenib 0 0
Crizotinib + Vemurafenib Crizotinib Vemurafenib 0 1
CX-072 + Vemurafenib CX-072 Vemurafenib 0 1
Dactolisib + Vemurafenib Dactolisib Vemurafenib 1 0
Dasatinib + Gefitinib + Vemurafenib Dasatinib Gefitinib Vemurafenib 1 0
Dasatinib + Vemurafenib Dasatinib Vemurafenib 1 0
Decitabine + Vemurafenib Decitabine Vemurafenib 0 1
DETD-35 + Vemurafenib DETD-35 Vemurafenib 2 0
Erlotinib + Vemurafenib Erlotinib Vemurafenib 4 0
Everolimus + Vemurafenib Everolimus Vemurafenib 0 1
Gefitinib + Vemurafenib Gefitinib Vemurafenib 1 0
Hydroxychloroquine + Vemurafenib Hydroxychloroquine Vemurafenib 0 1
Interferon alpha-2b + Vemurafenib Interferon alpha-2b Vemurafenib 0 1
Irinotecan + Panitumumab + Vemurafenib Irinotecan Panitumumab Vemurafenib 0 0
Irinotecan + Vemurafenib Irinotecan Vemurafenib 1 0
JQ1 + Vemurafenib JQ1 Vemurafenib 0 0
Lapatinib + Vemurafenib Lapatinib Vemurafenib 1 0
Lifirafenib + Vemurafenib Lifirafenib Vemurafenib 2 0
LY3009120 + Vemurafenib LY3009120 Vemurafenib 1 0
Metformin + Vemurafenib Metformin Vemurafenib 0 1
MK2206 + Vemurafenib MK2206 Vemurafenib 2 0
Nab-paclitaxel + Vemurafenib Nab-paclitaxel Vemurafenib 1 0
Navitoclax + Vemurafenib Navitoclax Vemurafenib 3 0
Obinutuzumab + Vemurafenib Obinutuzumab Vemurafenib 0 1
Onartuzumab + Vemurafenib Onartuzumab Vemurafenib 0 1
Osimertinib + Vemurafenib Osimertinib Vemurafenib 0 0
PAC-1 + Trametinib + Vemurafenib PAC-1 Trametinib Vemurafenib 1 0
PAC-1 + Vemurafenib PAC-1 Vemurafenib 1 0
Palbociclib + Vemurafenib Palbociclib Vemurafenib 1 0
Panitumumab + Vemurafenib Panitumumab Vemurafenib 5 0
Panobinostat + Vemurafenib Panobinostat Vemurafenib 1 0
Pembrolizumab + Vemurafenib Pembrolizumab Vemurafenib 0 0
PET-16 + Vemurafenib PET-16 Vemurafenib 1 0
Pexidartinib + Vemurafenib Pexidartinib Vemurafenib 0 1
Ponatinib + Vemurafenib Ponatinib Vemurafenib 1 0
PX-866 + Vemurafenib PX-866 Vemurafenib 1 0
Pyrvinium + Vemurafenib Pyrvinium Vemurafenib 1 0
Rifampin + Vemurafenib Rifampin Vemurafenib 0 1
Rituximab + Vemurafenib Rituximab Vemurafenib 0 1
Ruxolitinib + Vemurafenib Ruxolitinib Vemurafenib 1 0
S63845 + Vemurafenib S63845 Vemurafenib 1 0
SAH-p53-8 + Vemurafenib SAH-p53-8 Vemurafenib 0 0
SAR260301 + Vemurafenib SAR260301 Vemurafenib 1 1
Saracatinib + Vemurafenib Saracatinib Vemurafenib 1 0
SBI-0640756 + Vemurafenib SBI-0640756 Vemurafenib 1 0
Selumetinib + Vemurafenib Selumetinib Vemurafenib 2 0
SHP099 + Vemurafenib SHP099 Vemurafenib 2 0
Sorafenib + Vemurafenib Sorafenib Vemurafenib 0 2
Temsirolimus + Vemurafenib Temsirolimus Vemurafenib 0 1
Tizanidine + Vemurafenib Tizanidine Vemurafenib 0 1
Trametinib + Vemurafenib Trametinib Vemurafenib 7 0
Trientine + Vemurafenib Trientine Vemurafenib 0 1
Tunlametinib + Vemurafenib Tunlametinib Vemurafenib 2 0
TW-37 + Vemurafenib TW-37 Vemurafenib 2 0
UNC2025 + Vemurafenib UNC2025 Vemurafenib 1 0
Vemurafenib Vemurafenib 259 27
Vemurafenib + Voruciclib Vemurafenib Voruciclib 1 1
Vemurafenib + XL888 Vemurafenib XL888 1 1
Vemurafenib + ZM336372 Vemurafenib ZM336372 1 0
Vemurafenib + ZSTK474 Vemurafenib ZSTK474 1 0


Additional content available in CKB BOOST