Drug Detail

Drug Name Vemurafenib
Trade Name Zelboraf
Synonyms RO5185426|PLX4032
Drug Descriptions

Zelboraf (vemurafenib) inhibits BRAF V600E, wild-type BRAF, ARAF, and CRAF (PMID: 20179705), which may result in an inhibition of the MAPK signaling pathway resulting in a reduction of tumor cell proliferation (PMID: 20823850). Zelboraf (vemurafenib) is FDA approved for BRAF V600E-mutant melanoma and for BRAF V600-positive Erdheim-Chester disease (FDA.gov).

DrugClasses RAF Inhibitor (Pan) 16

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Therapy Name Drugs Efficacy Evidence Clinical Trials
A-1210477 + Cobimetinib + Vemurafenib A-1210477 Cobimetinib Vemurafenib 0 0
A-1210477 + Vemurafenib A-1210477 Vemurafenib 0 0
Acitretin + Vemurafenib Acitretin Vemurafenib 0 1
Aldesleukin + Alpha 2 Interferon + Vemurafenib Aldesleukin Alpha 2 Interferon Vemurafenib 0 1
Aldesleukin + Vemurafenib Aldesleukin Vemurafenib 0 2
Atezolizumab + Cobimetinib + Vemurafenib Atezolizumab Cobimetinib Vemurafenib 1 3
Atezolizumab + Vemurafenib Atezolizumab Vemurafenib 0 1
BEZ235 + Vemurafenib BEZ235 Vemurafenib 0 0
Buparlisib + Vemurafenib Buparlisib Vemurafenib 1 1
Cabozantinib + Vemurafenib Cabozantinib Vemurafenib 0 1
Carboplatin + Paclitaxel + Vemurafenib Carboplatin Paclitaxel Vemurafenib 0 1
CDX-3379 + Vemurafenib CDX-3379 Vemurafenib 0 2
Cetuximab + Irinotecan + Vemurafenib Cetuximab Irinotecan Vemurafenib 3 2
Cetuximab + Selumetinib + Vemurafenib Cetuximab Selumetinib Vemurafenib 0 0
Cetuximab + Vemurafenib Cetuximab Vemurafenib 14 0
Cobimetinib + LY3022855 + Vemurafenib Cobimetinib LY3022855 Vemurafenib 0 1
Cobimetinib + Onartuzumab + Vemurafenib Cobimetinib Onartuzumab Vemurafenib 0 1
Cobimetinib + Vemurafenib Cobimetinib Vemurafenib 10 9
Cobimetinib + Vemurafenib + XL888 Cobimetinib Vemurafenib XL888 0 1
CPI-455 + Vemurafenib CPI-455 Vemurafenib 0 0
Crizotinib + Vemurafenib Crizotinib Vemurafenib 2 0
CX-072 + Vemurafenib CX-072 Vemurafenib 0 1
Decitabine + Vemurafenib Decitabine Vemurafenib 0 1
DETD-35 + Vemurafenib DETD-35 Vemurafenib 2 0
Erlotinib + Vemurafenib Erlotinib Vemurafenib 1 0
Everolimus + Vemurafenib Everolimus Vemurafenib 0 1
Gefitinib + Vemurafenib Gefitinib Vemurafenib 1 0
Hydroxychloroquine + Vemurafenib Hydroxychloroquine Vemurafenib 0 1
Interferon alpha-2b + Vemurafenib Interferon alpha-2b Vemurafenib 0 1
Irinotecan + Panitumumab + Vemurafenib Irinotecan Panitumumab Vemurafenib 2 0
JQ1 + Vemurafenib JQ1 Vemurafenib 0 0
Lapatinib + Vemurafenib Lapatinib Vemurafenib 1 0
Metformin + Vemurafenib Metformin Vemurafenib 0 1
MK2206 + Vemurafenib MK2206 Vemurafenib 2 0
Navitoclax + Vemurafenib Navitoclax Vemurafenib 3 0
Obinutuzumab + Vemurafenib Obinutuzumab Vemurafenib 0 1
Onartuzumab + Vemurafenib Onartuzumab Vemurafenib 0 1
PAC-1 + Trametinib + Vemurafenib PAC-1 Trametinib Vemurafenib 1 0
PAC-1 + Vemurafenib PAC-1 Vemurafenib 1 0
Palbociclib + Vemurafenib Palbociclib Vemurafenib 0 0
Panitumumab + Vemurafenib Panitumumab Vemurafenib 8 0
Pembrolizumab + Vemurafenib Pembrolizumab Vemurafenib 0 1
PET-16 + Vemurafenib PET-16 Vemurafenib 1 0
Pexidartinib + Vemurafenib Pexidartinib Vemurafenib 1 1
PX-866 + Vemurafenib PX-866 Vemurafenib 1 0
Rifampin + Vemurafenib Rifampin Vemurafenib 0 1
S63845 + Vemurafenib S63845 Vemurafenib 1 0
SAH-p53-8 + Vemurafenib SAH-p53-8 Vemurafenib 0 0
SAR260301 + Vemurafenib SAR260301 Vemurafenib 1 1
SBI-0640756 + Vemurafenib SBI-0640756 Vemurafenib 1 0
Selumetinib + Vemurafenib Selumetinib Vemurafenib 1 0
Sorafenib + Vemurafenib Sorafenib Vemurafenib 0 1
Temsirolimus + Vemurafenib Temsirolimus Vemurafenib 0 1
Tizanidine + Vemurafenib Tizanidine Vemurafenib 0 1
Trametinib + Vemurafenib Trametinib Vemurafenib 8 0
Trientine + Vemurafenib Trientine Vemurafenib 0 1
TW-37 + Vemurafenib TW-37 Vemurafenib 2 0
Vemurafenib Vemurafenib 95 23
Vemurafenib + Voruciclib Vemurafenib Voruciclib 1 1
Vemurafenib + XL888 Vemurafenib XL888 1 1
Vemurafenib + ZSTK474 Vemurafenib ZSTK474 0 0