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Drug Name Metformin
Trade Name Glucophage
Synonyms Apo-Metformin
Drug Descriptions

Glucophage (metformin) inhibits part of the mitochondrial respiratory chain and may exert antineoplastic effects through inhibition of mTOR and is FDA approved for type 2 diabetes (FDA.gov).

DrugClasses mTOR Inhibitor 51

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Therapy Name Drugs Efficacy Evidence Clinical Trials
AGI-5198 + Metformin AGI-5198 Metformin 1 0
Aldoxorubicin + Metformin Aldoxorubicin Metformin 1 0
Atorvastatin + Metformin Atorvastatin Metformin 0 2
Bemcentinib + Metformin Bemcentinib Metformin 0 0
BI2536 + Metformin BI2536 Metformin 1 0
Bortezomib + Metformin + Nelfinavir Bortezomib Metformin Nelfinavir 0 1
Capecitabine + Cisplatin + Epirubicin + Gemcitabine + Metformin Capecitabine Cisplatin Epirubicin Gemcitabine Metformin 1 0
Carboplatin + Docetaxel + Metformin + Pertuzumab + Trastuzumab Carboplatin Docetaxel Metformin Pertuzumab Trastuzumab 0 1
Carboplatin + Metformin + Paclitaxel Carboplatin Metformin Paclitaxel 0 2
Carboplatin + Metformin + Pemetrexed Carboplatin Metformin Pemetrexed 0 0
Cisplatin + Gemcitabine + Metformin Cisplatin Gemcitabine Metformin 1 0
Cisplatin + Metformin Cisplatin Metformin 0 2
Cytarabine + Metformin Cytarabine Metformin 0 1
Dabrafenib + Metformin + Trametinib Dabrafenib Metformin Trametinib 0 1
Digoxin + Metformin + Simvastatin Digoxin Metformin Simvastatin 0 1
Doxycycline + Metformin Doxycycline Metformin 0 2
Durvalumab + Metformin Durvalumab Metformin 0 1
Enzalutamide + Metformin Enzalutamide Metformin 0 1
Erlotinib + Metformin Erlotinib Metformin 0 1
Everolimus + Letrozole + Metformin Everolimus Letrozole Metformin 1 0
Everolimus + Metformin Everolimus Metformin 1 0
Gefitinib + Metformin Gefitinib Metformin 0 0
Gemcitabine + Metformin + Nab-paclitaxel Gemcitabine Metformin Nab-paclitaxel 0 1
JPH203 + Metformin JPH203 Metformin 1 0
Lapatinib + Metformin Lapatinib Metformin 0 1
Mefloquine + Memantine + Metformin + Temozolomide Mefloquine Memantine Metformin Temozolomide 0 1
Mefloquine + Metformin + Temozolomide Mefloquine Metformin Temozolomide 0 1
Memantine + Metformin + Temozolomide Memantine Metformin Temozolomide 0 1
Metformin Metformin 15 49
Metformin + Nelfinavir Metformin Nelfinavir 0 1
Metformin + Nivolumab Metformin Nivolumab 0 3
Metformin + OPC Metformin OPC 0 2
Metformin + Pembrolizumab Metformin Pembrolizumab 0 2
Metformin + Ritonavir Metformin Ritonavir 0 1
Metformin + Sapanisertib Metformin Sapanisertib 0 1
Metformin + Simvastatin Metformin Simvastatin 0 2
Metformin + Sirolimus Metformin Sirolimus 0 2
Metformin + Sorafenib Metformin Sorafenib 1 0
Metformin + Temozolomide Metformin Temozolomide 0 1
Metformin + Temsirolimus Metformin Temsirolimus 1 1
Metformin + Vandetanib Metformin Vandetanib 0 1
Metformin + Vemurafenib Metformin Vemurafenib 0 1


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