Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name AGI-5198
Trade Name
Synonyms AG5198|AGI 5198|IDH-C35
Drug Descriptions

AGI-5198 is a selective inhibitor of mutant forms of IDH1, which decreases production of R-2HG, potentially leading to reduced growth of IDH1-mutant tumor cells (PMID: 23558169, PMID: 26368816, PMID: 31151327).

DrugClasses IDH1 Inhibitor 8
CAS Registry Number 1355326-35-0


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
AGI-5198 AGI-5198 4 0
AGI-5198 + Crenolanib AGI-5198 Crenolanib 3 0
AGI-5198 + Metformin AGI-5198 Metformin 1 0
AGI-5198 + Olaparib AGI-5198 Olaparib 1 0
AGI-5198 + Radiotherapy AGI-5198 Radiotherapy 1 0
AGI-5198 + Talazoparib AGI-5198 Talazoparib 2 0
AGI-5198 + Trichostatin A AGI-5198 Trichostatin A 1 0
AGI-5198 + Vorinostat AGI-5198 Vorinostat 1 0

Additional content available in CKB BOOST