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Drug Name AGI-5198
Trade Name
Synonyms AG5198|AGI 5198|IDH-C35
Drug Descriptions

AGI-5198 is a selective inhibitor of mutant forms of IDH1, which decreases production of R-2HG, potentially leading to reduced growth of IDH1-mutant tumor cells (PMID: 23558169, PMID: 26368816, PMID: 31151327).

DrugClasses IDH1 Inhibitor 8

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Therapy Name Drugs Efficacy Evidence Clinical Trials
AGI-5198 AGI-5198 4 0
AGI-5198 + Crenolanib AGI-5198 Crenolanib 2 0
AGI-5198 + Metformin AGI-5198 Metformin 1 0
AGI-5198 + Olaparib AGI-5198 Olaparib 1 0
AGI-5198 + Radiotherapy AGI-5198 Radiotherapy 1 0
AGI-5198 + Talazoparib AGI-5198 Talazoparib 2 0
AGI-5198 + Trichostatin A AGI-5198 Trichostatin A 1 0
AGI-5198 + Vorinostat AGI-5198 Vorinostat 1 0


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