Therapy Detail

Therapy Name Metformin + AGI-5198
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
AGI-5198 IDH1 Inhibitor 7 AGI-5198 is a selective inhibitor of mutant forms of IDH1, which decreases production of R-2HG, potentially leading to reduced growth of IDH1-mutant tumor cells (PMID: 23558169).
Metformin Glucophage Apo-Metformin Glucophage (metformin) inhibits part of the mitochondrial respiratory chain and may exert antineoplastic effects through inhibition of mTOR (NCI Drug Dictionary). Glucophage (metformin) is FDA approved for type 2 diabetes (FDA.gov).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
IDH1 R132H colorectal cancer resistant Metformin + AGI-5198 Preclinical Actionable In a preclinical study, colorectal cancer cells harboring IDH1 R132H demonstrated increased cell proliferation when treated with a combination of Glucophage (metformin) and AGI-5198 (PMID: 26363012). 26363012
Clinical Trial Phase Therapies Title Recruitment Status