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Drug Name Crenolanib
Trade Name
Synonyms CP-868596
Drug Descriptions

Crenolanib is a type III receptor tyrosine kinase inhibitor of PDGFR-alpha/beta and FLT3, which results in inhibition of downstream signaling and prevents growth in tumor cells (PMID: 22745105, PMID: 24227820, PMID: 29137311).

DrugClasses FLT3 Inhibitor 53 PDGFR Inhibitor (Pan) 27

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Therapy Name Drugs Efficacy Evidence Clinical Trials
AGI-5198 + Crenolanib AGI-5198 Crenolanib 2 0
Crenolanib Crenolanib 46 5
Crenolanib + Cytarabine + Daunorubicin Crenolanib Cytarabine Daunorubicin 0 1
Crenolanib + Cytarabine + Filgrastim + Fludarabine + Idarubicin + Mitoxantrone Crenolanib Cytarabine Filgrastim Fludarabine Idarubicin Mitoxantrone 0 1
Crenolanib + Cytarabine + Mitoxantrone Crenolanib Cytarabine Mitoxantrone 0 1
Crenolanib + LAM-003 Crenolanib LAM-003 0 0
Crenolanib + Paclitaxel + Ramucirumab Crenolanib Paclitaxel Ramucirumab 0 1
Crenolanib + PRT062607 Crenolanib PRT062607 1 0
Crenolanib + Sorafenib Crenolanib Sorafenib 0 1
Crenolanib + Trametinib Crenolanib Trametinib 2 0


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