Drug Detail

Drug Name Trametinib
Trade Name Mekinist
Synonyms GSK1120212
Drug Descriptions

Mekinist (trametinib) inhibits MEK 1 and 2, which potentially leads to reduced tumor cell proliferation (PMID: 27956260). Mekinist (trametinib) is FDA approved for melanoma patients harboring BRAF V600E or BRAF V600K mutations, and in combination with Tafinlar (dabrafinib) for BRAF V600E/K-mutant melanoma, BRAF V600E- mutant non-small cell lung cancer, and BRAF V600E-mutant anaplastic thyroid cancer (FDA.gov).

DrugClasses MEK inhibitor (Pan) 20 MEK1 Inhibitor 20 MEK2 Inhibitor 18

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
6MHP vaccine + Dabrafenib + Trametinib 6MHP vaccine Dabrafenib Trametinib 0 1
ABT-737 + AZD8055 + Trametinib ABT-737 AZD8055 Trametinib 1 0
ABT-737 + BEZ235 + Trametinib ABT-737 BEZ235 Trametinib 1 0
ABT-737 + MK2206 + Trametinib ABT-737 MK2206 Trametinib 1 0
Afatinib + Trametinib Afatinib Trametinib 1 0
Afuresertib + Trametinib Afuresertib Trametinib 1 0
Alpelisib + CGM097 + Navitoclax + Trametinib Alpelisib CGM097 Navitoclax Trametinib 1 0
Alpelisib + Erlotinib + Navitoclax + Trametinib Alpelisib Erlotinib Navitoclax Trametinib 1 0
Altiratinib + Trametinib Altiratinib Trametinib 0 0
AMG 232 + Dabrafenib + Trametinib AMG 232 Dabrafenib Trametinib 1 1
AMG 232 + Trametinib AMG 232 Trametinib 1 1
APS-2-79 + Trametinib APS-2-79 Trametinib 3 0
ARQ092 + Trametinib Miransertib Trametinib 0 0
AZ628 + Trametinib AZ628 Trametinib 1 0
AZD4547 + Trametinib AZD4547 Trametinib 1 0
BGJ398 + Trametinib BGJ398 Trametinib 5 0
BI 882370 + Trametinib BI 882370 Trametinib 2 0
Buparlisib + Trametinib Buparlisib Trametinib 2 0
Capmatinib + Trametinib Capmatinib Trametinib 0 0
Carboplatin + Paclitaxel + Trametinib Carboplatin Paclitaxel Trametinib 0 1
Carboplatin + Trametinib Carboplatin Trametinib 0 1
CDX-3379 + Trametinib CDX-3379 Trametinib 0 1
Ceritinib + Trametinib Ceritinib Trametinib 0 1
Cetuximab + Dabrafenib + Trametinib Cetuximab Dabrafenib Trametinib 8 0
Cetuximab + Trametinib Cetuximab Trametinib 6 0
CGM097 + Navitoclax + Trametinib CGM097 Navitoclax Trametinib 0 0
CGM097 + Trametinib CGM097 Trametinib 0 0
Crizotinib + Trametinib Crizotinib Trametinib 2 0
Dabrafenib + Digoxin + Trametinib Dabrafenib Digoxin Trametinib 0 1
Dabrafenib + Durvalumab + Trametinib Dabrafenib Durvalumab Trametinib 0 1
Dabrafenib + Everolimus + Trametinib Dabrafenib Everolimus Trametinib 0 0
Dabrafenib + Ipilimumab + Trametinib Dabrafenib Ipilimumab Trametinib 0 1
Dabrafenib + Itacitinib + Trametinib Dabrafenib Itacitinib Trametinib 0 1
Dabrafenib + MCS110 + Trametinib Dabrafenib MCS110 Trametinib 0 1
Dabrafenib + Metformin + Trametinib Dabrafenib Metformin Trametinib 0 1
Dabrafenib + Navitoclax + Trametinib Dabrafenib Navitoclax Trametinib 0 1
Dabrafenib + Nivolumab + Trametinib Dabrafenib Nivolumab Trametinib 0 1
Dabrafenib + Onalespib + Trametinib Dabrafenib Onalespib Trametinib 0 1
Dabrafenib + Panitumumab + Trametinib Dabrafenib Panitumumab Trametinib 4 1
Dabrafenib + Pembrolizumab + Trametinib Dabrafenib Pembrolizumab Trametinib 0 2
Dabrafenib + Phenformin + Trametinib Dabrafenib Phenformin Trametinib 0 1
Dabrafenib + SCH772984 + Trametinib Dabrafenib SCH772984 Trametinib 2 0
Dabrafenib + Spartalizumab + Trametinib Dabrafenib Spartalizumab Trametinib 0 2
Dabrafenib + Talimogene laherparepvec + Trametinib Dabrafenib Talimogene laherparepvec Trametinib 0 2
Dabrafenib + Trametinib Dabrafenib Trametinib 46 25
Dabrafenib + Trametinib + Uprosertib Dabrafenib Trametinib Uprosertib 0 0
Dasatinib + Trametinib Dasatinib Trametinib 3 0
Digoxin + Trametinib Digoxin Trametinib 0 1
Docetaxel + Trametinib Docetaxel Trametinib 4 2
Durvalumab + Trametinib Durvalumab Trametinib 0 2
Emibetuzumab + Trametinib Emibetuzumab Trametinib 0 1
Encorafenib + Trametinib Encorafenib Trametinib 6 0
Erlotinib + Trametinib Erlotinib Trametinib 0 2
Everolimus + Trametinib Everolimus Trametinib 0 1
Fluorouracil + Trametinib Fluorouracil Trametinib 1 1
Fulvestrant + Trametinib Fulvestrant Trametinib 0 0
Gefitinib + Trametinib Gefitinib Trametinib 1 0
Gemcitabine + Trametinib Gemcitabine Trametinib 3 1
GS-493 + Trametinib GS-493 Trametinib 1 0
GSK2126458 + Trametinib GSK2126458 Trametinib 8 0
GSK2256098 + Trametinib GSK2256098 Trametinib 0 1
Hydroxychloroquine + Trametinib Hydroxychloroquine Trametinib 0 1
Ibrutinib + Trametinib Ibrutinib Trametinib 0 0
Ipilimumab + Nivolumab + Trametinib Ipilimumab Nivolumab Trametinib 0 1
JQ1 + Trametinib JQ1 Trametinib 0 0
Lapatinib + Trametinib Lapatinib Trametinib 0 0
Lorlatinib + Trametinib Lorlatinib Trametinib 0 0
LXH 254 + Trametinib LXH 254 Trametinib 0 1
LY5 + Trametinib LY5 Trametinib 0 0
MK2206 + Trametinib MK2206 Trametinib 1 0
Momelotinib + Trametinib Momelotinib Trametinib 0 1
Nab-paclitaxel + Trametinib Nab-paclitaxel Trametinib 0 2
Navitoclax + Trametinib Navitoclax Trametinib 5 1
Nazartinib + Trametinib Nazartinib Trametinib 0 1
Neratinib + Trametinib Neratinib Trametinib 0 1
Nivolumab + Trametinib Nivolumab Trametinib 1 1
Olaparib + Trametinib Olaparib Trametinib 0 0
PAC-1 + Trametinib + Vemurafenib PAC-1 Trametinib Vemurafenib 1 0
Paclitaxel + Trametinib Paclitaxel Trametinib 0 1
Palbociclib + Trametinib Palbociclib Trametinib 13 1
Panitumumab + Trametinib Panitumumab Trametinib 4 2
Pazopanib + Trametinib Pazopanib Trametinib 3 1
Pembrolizumab + Trametinib Pembrolizumab Trametinib 1 4
Pemetrexed + Trametinib Pemetrexed Trametinib 2 1
Ponatinib + Trametinib Ponatinib Trametinib 5 1
RAF709 + Trametinib RAF709 Trametinib 1 0
Ribociclib + Trametinib Ribociclib Trametinib 0 2
Ruxolitinib + Trametinib Ruxolitinib Trametinib 0 0
S63845 + Trametinib S63845 Trametinib 2 0
SCH772984 + Trametinib SCH772984 Trametinib 1 0
SHP099 + Trametinib SHP099 Trametinib 4 0
Sirolimus + Trametinib Sirolimus Trametinib 2 0
Sorafenib + Trametinib Sorafenib Trametinib 0 1
Spartalizumab + Trametinib Spartalizumab Trametinib 0 1
Sunitinib + Trametinib Sunitinib Trametinib 2 0
Trametinib Trametinib 130 37
Trametinib + Triciribine Trametinib Triciribine 0 0
Trametinib + trifluridine/tipiracil hydrochloride Trametinib trifluridine/tipiracil hydrochloride 0 1
Trametinib + TW-37 TW-37 Trametinib 4 0
Trametinib + Uprosertib Trametinib Uprosertib 1 8
Trametinib + Vemurafenib Trametinib Vemurafenib 8 0
Trametinib + Volasertib Trametinib Volasertib 0 0
Trametinib + WZ4002 Trametinib WZ4002 0 0