Drug Detail

Drug Name Trametinib
Trade Name Mekinist
Synonyms GSK1120212
Drug Descriptions

Mekinist (trametinib) inhibits MEK 1 and 2, which potentially leads to reduced tumor cell proliferation (PMID: 27956260). Mekinist (trametinib) is FDA approved for melanoma patients harboring BRAF V600E or BRAF V600K mutations, and in combination with Tafinlar (dabrafinib) for BRAF V600E/K-mutant melanoma, BRAF V600E- mutant non-small cell lung cancer, and BRAF V600E-mutant anaplastic thyroid cancer (FDA.gov).

DrugClasses MEK inhibitor (Pan) 20 MEK1 Inhibitor 20 MEK2 Inhibitor 18

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Therapy Name Therapy Description
Trametinib + TW-37
GSK2126458 + Trametinib
Crizotinib + Trametinib
Dabrafenib + Trametinib + PDR001
MK2206 + Trametinib
Sorafenib + Trametinib
Emibetuzumab + Trametinib
ARQ092 + Trametinib
Dabrafenib + Trametinib + Metformin
ABT-737 + MK2206 + Trametinib
Pembrolizumab + Trametinib
Dabrafenib + Digoxin + Trametinib
Cetuximab + Trametinib
Trametinib + GSK2141795
Dabrafenib + Everolimus + Trametinib
Dabrafenib + INCB039110 + Trametinib
Gefitinib + Trametinib
Lapatinib + Trametinib
Nazartinib + Trametinib
Fulvestrant + Trametinib
Docetaxel + Trametinib
Dabrafenib + Trametinib + Phenformin
SHP099 + Trametinib
Dasatinib + Trametinib
Everolimus + GSK1120212
Olaparib + Trametinib
Palbociclib + Trametinib
APS-2-79 + Trametinib
Sirolimus + Trametinib
GS-493 + Trametinib
ABT-263 + Alpelisib + CGM097 + Trametinib
GSK2256098 + Trametinib
Panitumumab + Trametinib
JQ1 + Trametinib
Afatinib + Trametinib
Ibrutinib + Trametinib
Dabrafenib + Ipilimumab + Trametinib
Ipilimumab + Nivolumab + Trametinib
Momelotinib + Trametinib
Erlotinib + Trametinib
AT13387 + Dabrafenib + Trametinib
Trametinib + Fluorouracil
Dabrafenib + Trametinib + MCS110
Neratinib + Trametinib
Panitumumab + Trametinib + Dabrafenib
CDX-3379 + Trametinib
SCH772984 + Trametinib
Trametinib + Paclitaxel
Trametinib + Volasertib
Trametinib + Vemurafenib
Ceritinib + Trametinib
Nivolumab + Trametinib
Pemetrexed + GSK1120212
Altiratinib + Trametinib
Trametinib + Digoxin
S63845 + Trametinib
Trametinib + trifluridine/tipiracil hydrochloride
AMG 232 + Trametinib + Dabrafenib
AZ628 + Trametinib
Ruxolitinib + Trametinib
CGM097 + Trametinib
Trametinib + Dabrafenib
Afuresertib + Trametinib
INC280 + Trametinib
BI 882370 + Trametinib
Ponatinib + Trametinib
Dabrafenib + Nivolumab + Trametinib
Dabrafenib + Trametinib + GSK2141795
Carboplatin + GSK1120212
Dabrafenib + Durvalumab + Trametinib
AMG 232 + Trametinib
ABT-263 + CGM097 + Trametinib
PDR001 + Trametinib
Hydroxychloroquine + Trametinib Mekinist (trametinib) inhibits MEK 1 and 2, which potentially leads to reduced tumor cell proliferation (PMID: 27956260). Mekinist (trametinib) is FDA approved for melanoma patients harboring BRAF V600E or BRAF V600K mutations, and in combination with Tafinlar (dabrafinib) for BRAF V600E/K-mutant melanoma, BRAF V600E- mutant non-small cell lung cancer, and BRAF V600E-mutant anaplastic thyroid cancer (FDA.gov).
talimogene laherparepvec + Dabrafenib + Trametinib
AZD4547 + Trametinib
Encorafenib + Trametinib
ABT-737 + AZD8055 + Trametinib
nab-paclitaxel + GSK1120212
Durvalumab + Trametinib
RAF709 + Trametinib
PAC-1 + Trametinib + Vemurafenib
Trametinib
Trametinib + Triciribine
BKM120 + Trametinib
Trametinib + Navitoclax
WZ4002 + Trametinib
LY5 + Trametinib
ABT-263 + Alpelisib + Erlotinib + Trametinib
Trametinib + Dabrafenib + Navitoclax
Cetuximab + Dabrafenib + Trametinib
Pazopanib + Trametinib
Ribociclib + Trametinib
BGJ398 + Trametinib
Dabrafenib + SCH772984 + Trametinib
Lorlatinib + Trametinib
Carboplatin + Paclitaxel + Trametinib
ABT-737 + BEZ235 + Trametinib
Gemcitabine + GSK1120212
Pembrolizumab + Dabrafenib + Trametinib
Sunitinib + Trametinib