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Drug Name Trametinib
Trade Name Mekinist
Synonyms GSK1120212
Drug Descriptions

Mekinist (trametinib) inhibits MEK 1 and 2, which potentially leads to reduced tumor cell proliferation (PMID: 27956260). Mekinist (trametinib) is FDA approved for melanoma patients harboring BRAF V600E or BRAF V600K mutations, and in combination with Tafinlar (dabrafinib) for BRAF V600E/K-mutant melanoma, BRAF V600E- mutant non-small cell lung cancer, and BRAF V600E-mutant anaplastic thyroid cancer (FDA.gov).

DrugClasses MEK inhibitor (Pan) 22 MEK1 Inhibitor 20 MEK2 Inhibitor 18
CAS Registry Number 871700-17-3
NCIT ID C77908

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Therapy Name Drugs Efficacy Evidence Clinical Trials
6MHP vaccine + Dabrafenib + Trametinib 6MHP vaccine Dabrafenib Trametinib 0 1
ABT-737 + AZD8055 + Trametinib ABT-737 AZD8055 Trametinib 0 0
ABT-737 + Dactolisib + Trametinib ABT-737 Dactolisib Trametinib 0 0
ABT-737 + MK2206 + Trametinib ABT-737 MK2206 Trametinib 0 0
Afatinib + Crizotinib + Trametinib Afatinib Crizotinib Trametinib 0 0
Afatinib + Trametinib Afatinib Trametinib 0 0
Afuresertib + Trametinib Afuresertib Trametinib 0 0
Alpelisib + CGM097 + Navitoclax + Trametinib Alpelisib CGM097 Navitoclax Trametinib 0 0
Alpelisib + Erlotinib + Navitoclax + Trametinib Alpelisib Erlotinib Navitoclax Trametinib 0 0
Alpelisib + Gefitinib + Trametinib Alpelisib Gefitinib Trametinib 0 0
Alpelisib + Trametinib Alpelisib Trametinib 0 1
Altiratinib + Trametinib Altiratinib Trametinib 0 0
Anakinra + Bevacizumab + Fluorouracil + Oxaliplatin + Trametinib Anakinra Bevacizumab Fluorouracil Oxaliplatin Trametinib 0 0
Anakinra + Palbociclib + Trametinib Anakinra Palbociclib Trametinib 0 0
APS-2-79 + Trametinib APS-2-79 Trametinib 0 0
AZ628 + Trametinib AZ628 Trametinib 0 0
Azacitidine + Trametinib + Venetoclax Azacitidine Trametinib Venetoclax 0 1
AZD0364 + Trametinib AZD0364 Trametinib 0 0
AZD4547 + Trametinib AZD4547 Trametinib 0 0
AZD8055 + Linsitinib + Trametinib AZD8055 Linsitinib Trametinib 0 0
AZD8055 + Trametinib AZD8055 Trametinib 0 0
BGB-283 + Trametinib BGB-283 Trametinib 4 0
BI 1701963 + Trametinib BI 1701963 Trametinib 0 1
BI 882370 + Trametinib BI 882370 Trametinib 2 0
BI-3406 + Trametinib BI-3406 Trametinib 0 0
BMS-777607 + Trametinib BMS-777607 Trametinib 0 0
Borussertib + Trametinib Borussertib Trametinib 0 0
Buparlisib + Trametinib Buparlisib Trametinib 1 0
Cabozantinib + Trametinib Cabozantinib Trametinib 0 0
Capmatinib + Dabrafenib + Trametinib Capmatinib Dabrafenib Trametinib 0 0
Capmatinib + Trametinib Capmatinib Trametinib 0 0
Carboplatin + Paclitaxel + Trametinib Carboplatin Paclitaxel Trametinib 0 1
Carboplatin + Trametinib Carboplatin Trametinib 0 1
CDX-3379 + Trametinib CDX-3379 Trametinib 0 1
Cemiplimab + Dabrafenib + Trametinib Cemiplimab Dabrafenib Trametinib 0 1
Ceritinib + Trametinib Ceritinib Trametinib 0 1
Cetuximab + Dabrafenib + Trametinib Cetuximab Dabrafenib Trametinib 3 0
Cetuximab + Trametinib Cetuximab Trametinib 6 0
CGM097 + Navitoclax + Trametinib CGM097 Navitoclax Trametinib 0 0
CGM097 + Trametinib CGM097 Trametinib 0 0
Chloroquine + Trametinib Chloroquine Trametinib 3 0
Crenolanib + Trametinib Crenolanib Trametinib 1 0
Crizotinib + Trametinib Crizotinib Trametinib 0 0
Dabrafenib + Digoxin + Trametinib Dabrafenib Digoxin Trametinib 0 1
Dabrafenib + Durvalumab + Trametinib Dabrafenib Durvalumab Trametinib 0 1
Dabrafenib + Everolimus + Trametinib Dabrafenib Everolimus Trametinib 1 0
Dabrafenib + Hydroxychloroquine + Trametinib Dabrafenib Hydroxychloroquine Trametinib 0 4
Dabrafenib + Ipilimumab + Nivolumab + Trametinib Dabrafenib Ipilimumab Nivolumab Trametinib 0 1
Dabrafenib + Ipilimumab + Trametinib Dabrafenib Ipilimumab Trametinib 0 2
Dabrafenib + Itacitinib + Trametinib Dabrafenib Itacitinib Trametinib 0 1
Dabrafenib + KRT-232 + Trametinib Dabrafenib KRT-232 Trametinib 2 1
Dabrafenib + Larotrectinib + Trametinib Dabrafenib Larotrectinib Trametinib 0 0
Dabrafenib + LOXO-195 + Trametinib Dabrafenib LOXO-195 Trametinib 0 0
Dabrafenib + LTT462 + Trametinib Dabrafenib LTT462 Trametinib 0 1
Dabrafenib + LXH 254 + Trametinib Dabrafenib LXH 254 Trametinib 2 0
Dabrafenib + MCS110 + Trametinib Dabrafenib MCS110 Trametinib 0 1
Dabrafenib + Metformin + Trametinib Dabrafenib Metformin Trametinib 0 1
Dabrafenib + Navitoclax + Trametinib Dabrafenib Navitoclax Trametinib 0 1
Dabrafenib + Nilotinib + Trametinib Dabrafenib Nilotinib Trametinib 0 1
Dabrafenib + Nivolumab + Trametinib Dabrafenib Nivolumab Trametinib 1 1
Dabrafenib + Onalespib + Trametinib Dabrafenib Onalespib Trametinib 0 1
Dabrafenib + Osimertinib + Trametinib Dabrafenib Osimertinib Trametinib 0 0
Dabrafenib + Panitumumab + Trametinib Dabrafenib Panitumumab Trametinib 2 1
Dabrafenib + Pembrolizumab + Trametinib Dabrafenib Pembrolizumab Trametinib 3 3
Dabrafenib + Phenformin + Trametinib Dabrafenib Phenformin Trametinib 0 1
Dabrafenib + Rabeprazole + Rifampin + Trametinib Dabrafenib Rabeprazole Rifampin Trametinib 1 0
Dabrafenib + RAF709 + Trametinib Dabrafenib RAF709 Trametinib 2 0
Dabrafenib + Regorafenib + Trametinib Dabrafenib Regorafenib Trametinib 3 0
Dabrafenib + SCH772984 + Trametinib Dabrafenib SCH772984 Trametinib 2 0
Dabrafenib + Spartalizumab + Trametinib Dabrafenib Spartalizumab Trametinib 1 3
Dabrafenib + Talimogene laherparepvec + Trametinib Dabrafenib Talimogene laherparepvec Trametinib 0 2
Dabrafenib + Tazemetostat + Trametinib Dabrafenib Tazemetostat Trametinib 0 1
Dabrafenib + TNO155 + Trametinib Dabrafenib TNO155 Trametinib 0 1
Dabrafenib + Trametinib Dabrafenib Trametinib 74 33
Dabrafenib + Trametinib + Uprosertib Dabrafenib Trametinib Uprosertib 0 1
Dasatinib + Trametinib Dasatinib Trametinib 1 0
DCC-3116 + Trametinib DCC-3116 Trametinib 0 1
Defactinib + Trametinib Defactinib Trametinib 0 0
Digoxin + Trametinib Digoxin Trametinib 0 1
Docetaxel + Trametinib Docetaxel Trametinib 0 2
Durvalumab + Trametinib Durvalumab Trametinib 0 2
Emibetuzumab + Trametinib Emibetuzumab Trametinib 0 1
Encorafenib + Trametinib Encorafenib Trametinib 4 0
Erlotinib + Trametinib Erlotinib Trametinib 0 2
Everolimus + Linsitinib + Trametinib Everolimus Linsitinib Trametinib 0 0
Everolimus + Pictilisib + Trametinib Everolimus Pictilisib Trametinib 0 0
Everolimus + Trametinib Everolimus Trametinib 0 2
Fluorouracil + Trametinib Fluorouracil Trametinib 0 1
Fulvestrant + Trametinib Fulvestrant Trametinib 0 0
Gefitinib + Trametinib Gefitinib Trametinib 0 0
Gemcitabine + Trametinib Gemcitabine Trametinib 0 1
GS-493 + Trametinib GS-493 Trametinib 0 0
GSK2126458 + Trametinib GSK2126458 Trametinib 7 0
GSK2256098 + Trametinib GSK2256098 Trametinib 0 1
HDM201 + Trametinib HDM201 Trametinib 0 1
Hydroxychloroquine + Trametinib Hydroxychloroquine Trametinib 0 4
I-BET151 + Trametinib I-BET151 Trametinib 1 0
Ibrutinib + Trametinib Ibrutinib Trametinib 0 0
Infigratinib + Trametinib Infigratinib Trametinib 8 0
Ipilimumab + Nivolumab + Trametinib Ipilimumab Nivolumab Trametinib 0 2
Ipilimumab + Trametinib Ipilimumab Trametinib 0 1
JQ1 + Trametinib JQ1 Trametinib 0 0
KRT-232 + Trametinib KRT-232 Trametinib 0 1
Lapatinib + Trametinib Lapatinib Trametinib 0 0
Larotrectinib + Trametinib Larotrectinib Trametinib 0 0
Linsitinib + Sapanisertib + Trametinib Linsitinib Sapanisertib Trametinib 0 0
Linsitinib + Torkinib + Trametinib Linsitinib Torkinib Trametinib 0 0
Lorlatinib + Trametinib Lorlatinib Trametinib 0 0
LOXO-195 + Trametinib LOXO-195 Trametinib 0 0
LXH 254 + Trametinib LXH 254 Trametinib 1 1
LY3009120 + Trametinib LY3009120 Trametinib 1 0
LY5 + Trametinib LY5 Trametinib 0 0
Miransertib + Trametinib Miransertib Trametinib 1 0
MK2206 + Trametinib MK2206 Trametinib 1 0
Momelotinib + Trametinib Momelotinib Trametinib 0 1
Nab-paclitaxel + Trametinib Nab-paclitaxel Trametinib 0 2
Navitoclax + Trametinib Navitoclax Trametinib 3 1
Nazartinib + Trametinib Nazartinib Trametinib 0 2
Neratinib + Trametinib Neratinib Trametinib 0 1
Nivolumab + Trametinib Nivolumab Trametinib 0 2
NVP-TNKS656 + Trametinib NVP-TNKS656 Trametinib 0 0
Olaparib + Trametinib Olaparib Trametinib 0 0
Olaparib + Trametinib + unspecified PD-L1 antibody Olaparib Trametinib unspecified PD-L1 antibody 0 0
Osimertinib + RAF709 + Trametinib Osimertinib RAF709 Trametinib 0 0
Osimertinib + SCH772984 + Trametinib Osimertinib SCH772984 Trametinib 0 0
Osimertinib + Trametinib Osimertinib Trametinib 0 0
PAC-1 + Trametinib + Vemurafenib PAC-1 Trametinib Vemurafenib 1 0
Paclitaxel + Trametinib Paclitaxel Trametinib 0 1
Palbociclib + Trametinib Palbociclib Trametinib 10 1
Panitumumab + Trametinib Panitumumab Trametinib 3 3
Pazopanib + Trametinib Pazopanib Trametinib 1 1
Pembrolizumab + Trametinib Pembrolizumab Trametinib 1 4
Pemetrexed Disodium + Trametinib Pemetrexed Disodium Trametinib 0 1
Ponatinib + Trametinib Ponatinib Trametinib 0 1
RAF265 + Trametinib RAF265 Trametinib 3 0
RAF709 + Trametinib RAF709 Trametinib 0 0
Regorafenib + Trametinib Regorafenib Trametinib 2 0
Repotrectinib + Trametinib Repotrectinib Trametinib 0 1
Ribociclib + Trametinib Ribociclib Trametinib 0 2
Rigosertib + Trametinib Rigosertib Trametinib 0 0
Ripretinib + Trametinib Ripretinib Trametinib 0 0
Ruxolitinib + Trametinib Ruxolitinib Trametinib 1 0
RXDX-105 + Trametinib RXDX-105 Trametinib 1 0
S63845 + Trametinib S63845 Trametinib 2 0
Sapanisertib + Trametinib Sapanisertib Trametinib 0 0
SCH772984 + Trametinib SCH772984 Trametinib 0 0
SHP099 + Trametinib SHP099 Trametinib 1 0
Sirolimus + Trametinib Sirolimus Trametinib 2 0
Sorafenib + Trametinib Sorafenib Trametinib 1 1
Sotorasib + Trametinib Sotorasib Trametinib 0 0
Spartalizumab + Trametinib Spartalizumab Trametinib 0 2
Sunitinib + Trametinib Sunitinib Trametinib 1 0
Tazemetostat + Trametinib Tazemetostat Trametinib 0 0
Torkinib + Trametinib Torkinib Trametinib 0 0
Trametinib Trametinib 153 36
Trametinib + Triciribine Trametinib Triciribine 0 0
Trametinib + Trifluridine-tipiracil hydrochloride Trametinib Trifluridine-tipiracil hydrochloride 0 1
Trametinib + TW-37 TW-37 Trametinib 2 0
Trametinib + unspecified PD-L1 antibody Trametinib unspecified PD-L1 antibody 0 0
Trametinib + Uprosertib Trametinib Uprosertib 0 8
Trametinib + Vemurafenib Trametinib Vemurafenib 6 0
Trametinib + Volasertib Trametinib Volasertib 0 0
Trametinib + VS-4718 Trametinib VS-4718 0 0
Trametinib + WZ4002 Trametinib WZ4002 0 0
Trametinib + YM-254890 Trametinib YM-254890 1 0
Trametinib + Zoledronic acid Trametinib Zoledronic acid 0 0


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