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Drug Name Ribociclib
Trade Name Kisqali
Synonyms LEE011|LEE-011|LEE 011
Drug Descriptions

Kisqali (ribociclib) is a dual CDK4/6 inhibitor, which may induce cell cycle arrest and reduce proliferation in cancer cells (PMID: 24045179). Kisqali (ribociclib) is FDA-approved in combination with an aromatase inhibitor in women with hormone receptor-positive, ERBB2 (HER2)-negative breast cancer, and in combination with Faslodex (fulvestrant) in postmenopausal women with hormone receptor-positive, ERBB2 (HER2)-negative breast cancer (FDA.gov).

DrugClasses CDK4/6 Inhibitor 13
CAS Registry Number 1211441-98-3
NCIT ID C95701

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Therapy Name Drugs Efficacy Evidence Clinical Trials
177Lu-NeoB + Fulvestrant + Ribociclib 177Lu-NeoB Fulvestrant Ribociclib 0 1
Alpelisib + Fulvestrant + Ribociclib Alpelisib Fulvestrant Ribociclib 0 1
Alpelisib + Letrozole + Ribociclib Alpelisib Letrozole Ribociclib 0 1
Alpelisib + Ribociclib Alpelisib Ribociclib 0 0
Anastrozole + Goserelin + Ribociclib Anastrozole Goserelin Ribociclib 0 3
Anastrozole + Leuprolide + Ribociclib Anastrozole Leuprolide Ribociclib 0 1
Anastrozole + Pertuzumab + Ribociclib + Trastuzumab Anastrozole Pertuzumab Ribociclib Trastuzumab 0 1
Anastrozole + Ribociclib Anastrozole Ribociclib 0 8
ARTS-021 + Fulvestrant + Ribociclib ARTS-021 Fulvestrant Ribociclib 0 0
ARTS-021 + Letrozole + Ribociclib ARTS-021 Letrozole Ribociclib 0 0
Asparaginase + Ribociclib Asparaginase Ribociclib 0 0
AZD8421 + Camizestrant + Ribociclib AZD8421 Camizestrant Ribociclib 0 1
Belinostat + Ribociclib Belinostat Ribociclib 0 1
Bicalutamide + Ribociclib Bicalutamide Ribociclib 0 1
Binimetinib + Encorafenib + Ribociclib Binimetinib Encorafenib Ribociclib 0 3
Binimetinib + PF-4708671 + Ribociclib Binimetinib PF-4708671 Ribociclib 2 0
Binimetinib + Ribociclib Binimetinib Ribociclib 10 1
Binimetinib + Ribociclib + Sirolimus Binimetinib Ribociclib Sirolimus 2 0
BLU-222 + Fulvestrant + Ribociclib BLU-222 Fulvestrant Ribociclib 0 1
Bortezomib + Ribociclib Bortezomib Ribociclib 0 0
Buparlisib + Fulvestrant + Ribociclib Buparlisib Fulvestrant Ribociclib 0 1
Buparlisib + Letrozole + Ribociclib Buparlisib Letrozole Ribociclib 0 1
C188-9 + Ribociclib C188-9 Ribociclib 0 1
Camizestrant + Ribociclib Camizestrant Ribociclib 0 1
Capecitabine + Ribociclib Capecitabine Ribociclib 0 1
Capivasertib + Fulvestrant + Ribociclib Capivasertib Fulvestrant Ribociclib 0 1
Carboplatin + Paclitaxel + Ribociclib Carboplatin Paclitaxel Ribociclib 0 1
Ceritinib + Ribociclib Ceritinib Ribociclib 5 2
Crizotinib + Ribociclib Crizotinib Ribociclib 0 0
Dexamethasone + Everolimus + Ribociclib Dexamethasone Everolimus Ribociclib 0 1
Dexamethasone + Ribociclib Dexamethasone Ribociclib 0 1
Docetaxel + Filgrastim + Prednisone + Ribociclib Docetaxel Filgrastim Prednisone Ribociclib 0 1
Doxorubicin + Ribociclib Doxorubicin Ribociclib 0 1
Elacestrant + Ribociclib Elacestrant Ribociclib 0 2
Encorafenib + Ribociclib Encorafenib Ribociclib 1 2
Everolimus + Exemestane + Ribociclib Everolimus Exemestane Ribociclib 0 2
Everolimus + Letrozole + Ribociclib Everolimus Letrozole Ribociclib 0 1
Everolimus + Ribociclib Everolimus Ribociclib 0 7
Exemestane + Goserelin + Ribociclib Exemestane Goserelin Ribociclib 0 1
Exemestane + Leuprolide + Ribociclib Exemestane Leuprolide Ribociclib 0 1
Exemestane + Pertuzumab + Ribociclib + Trastuzumab Exemestane Pertuzumab Ribociclib Trastuzumab 0 1
Exemestane + Ribociclib Exemestane Ribociclib 0 5
Filgrastim + Gemcitabine + Pegfilgrastim + Ribociclib Filgrastim Gemcitabine Pegfilgrastim Ribociclib 0 0
Filgrastim + Gemcitabine + Ribociclib Filgrastim Gemcitabine Ribociclib 0 1
Fulvestrant + MK2206 + Ribociclib Fulvestrant MK2206 Ribociclib 1 0
Fulvestrant + Pertuzumab + Ribociclib + Trastuzumab Fulvestrant Pertuzumab Ribociclib Trastuzumab 0 1
Fulvestrant + Ribociclib Fulvestrant Ribociclib 1 14
Fulvestrant + Ribociclib + RLY-2608 Fulvestrant RLY-2608 Ribociclib 0 0
Fulvestrant + Ribociclib + RLY-5836 Fulvestrant RLY-5836 Ribociclib 0 1
Fulvestrant + Ribociclib + Spartalizumab Fulvestrant Ribociclib Spartalizumab 0 1
Fulvestrant + Ribociclib + Trastuzumab + Tucatinib Fulvestrant Ribociclib Trastuzumab Tucatinib 0 1
Gemcitabine + Ribociclib Gemcitabine Ribociclib 0 2
Giredestrant + Ribociclib Giredestrant Ribociclib 0 2
Goserelin + Letrozole + Ribociclib Goserelin Letrozole Ribociclib 0 3
Goserelin + Pertuzumab + Ribociclib + Trastuzumab Goserelin Pertuzumab Ribociclib Trastuzumab 0 1
Goserelin + Ribociclib Goserelin Ribociclib 0 1
Goserelin + Ribociclib + Tamoxifen Goserelin Ribociclib Tamoxifen 0 1
H3B-5942 + Ribociclib H3B-5942 Ribociclib 0 0
Ipatasertib + Ribociclib Ipatasertib Ribociclib 1 0
JDQ443 + Ribociclib JDQ443 Ribociclib 0 1
JQ1 + Ribociclib JQ1 Ribociclib 0 0
Letrozole + Leuprolide + Ribociclib Letrozole Leuprolide Ribociclib 0 1
Letrozole + Pertuzumab + Ribociclib + Trastuzumab Letrozole Pertuzumab Ribociclib Trastuzumab 0 1
Letrozole + Ribociclib Letrozole Ribociclib 1 18
Leuprolide + Pertuzumab + Ribociclib + Trastuzumab Leuprolide Pertuzumab Ribociclib Trastuzumab 0 1
LGH447 + Ribociclib + Ruxolitinib LGH447 Ribociclib Ruxolitinib 2 0
LSZ 102 + Ribociclib LSZ 102 Ribociclib 0 1
LXH 254 + Ribociclib LXH 254 Ribociclib 0 1
Mercaptopurine + Ribociclib Mercaptopurine Ribociclib 0 0
Methotrexate + Ribociclib Methotrexate Ribociclib 0 0
MK2206 + Ribociclib MK2206 Ribociclib 1 0
Nazartinib + Ribociclib Nazartinib Ribociclib 0 1
Neratinib + Ribociclib Neratinib Ribociclib 0 0
Paclitaxel + Ribociclib Paclitaxel Ribociclib 0 1
Palazestrant + Ribociclib Palazestrant Ribociclib 0 1
Prednisolone + Ribociclib Prednisolone Ribociclib 0 0
Ribociclib Ribociclib 7 31
Ribociclib + SHP099 Ribociclib SHP099 0 0
Ribociclib + Siremadlin Ribociclib Siremadlin 0 2
Ribociclib + Sonidegib Ribociclib Sonidegib 0 1
Ribociclib + Spartalizumab Ribociclib Spartalizumab 0 1
Ribociclib + Tamoxifen Ribociclib Tamoxifen 0 2
Ribociclib + Temozolomide + Topotecan Ribociclib Temozolomide Topotecan 0 2
Ribociclib + TNO155 Ribociclib TNO155 0 1
Ribociclib + Trametinib Ribociclib Trametinib 0 3
Ribociclib + Trastuzumab + Tucatinib Ribociclib Trastuzumab Tucatinib 0 1
Ribociclib + Vepdegestrant Ribociclib Vepdegestrant 0 1
Ribociclib + XVir-N-31 Ribociclib XVir-N-31 0 0


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