Drug Detail

Drug Name Ribociclib
Trade Name Kisqali
Synonyms LEE011
Drug Descriptions

Kisqali (ribociclib) is a dual CDK4/6 inhibitor, which may induce cell cycle arrest and reduce proliferation in cancer cells (PMID: 24045179). Kisqali (ribociclib) is FDA-approved in combination with an aromatase inhibitor in women with hormone receptor-positive, ERBB2 (HER2)-negative breast cancer, and in combination with Faslodex (fulvestrant) in postmenopausal women with hormone receptor-positive, ERBB2 (HER2)-negative breast cancer (FDA.gov).

DrugClasses CDK4/6 Inhibitor 8

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Alpelisib + Fulvestrant + Ribociclib Alpelisib Fulvestrant Ribociclib 0 1
Alpelisib + Letrozole + Ribociclib Alpelisib Letrozole Ribociclib 0 1
Alpelisib + Ribociclib Alpelisib Ribociclib 0 0
Anastrozole + Ribociclib Anastrozole Ribociclib 0 0
Asparaginase + Ribociclib Asparaginase Ribociclib 2 0
Bicalutamide + Ribociclib Bicalutamide Ribociclib 0 1
Binimetinib + Encorafenib + Ribociclib Binimetinib Encorafenib Ribociclib 0 2
Binimetinib + Ribociclib Binimetinib Ribociclib 2 1
Bortezomib + Ribociclib Bortezomib Ribociclib 2 0
Buparlisib + Fulvestrant + Ribociclib Buparlisib Fulvestrant Ribociclib 0 1
Buparlisib + Letrozole + Ribociclib Buparlisib Letrozole Ribociclib 0 1
Carboplatin + Paclitaxel + Ribociclib Carboplatin Paclitaxel Ribociclib 0 1
Ceritinib + Ribociclib Ceritinib Ribociclib 0 2
Dexamethasone + Everolimus + Ribociclib Dexamethasone Everolimus Ribociclib 0 1
Dexamethasone + Ribociclib Dexamethasone Ribociclib 3 1
Docetaxel + Filgrastim + Prednisone + Ribociclib Docetaxel Filgrastim Prednisone Ribociclib 0 1
Doxorubicin + Ribociclib Doxorubicin Ribociclib 0 1
Encorafenib + Ribociclib Encorafenib Ribociclib 1 2
Everolimus + Exemestane + Ribociclib Everolimus Exemestane Ribociclib 0 2
Everolimus + Letrozole + Ribociclib Everolimus Letrozole Ribociclib 0 1
Everolimus + Ribociclib Everolimus Ribociclib 2 6
Exemestane + Ribociclib Exemestane Ribociclib 0 1
Filgrastim + Gemcitabine + Pegfilgrastim + Ribociclib Filgrastim Gemcitabine Pegfilgrastim Ribociclib 0 1
Fulvestrant + Ribociclib Fulvestrant Ribociclib 0 3
Fulvestrant + Ribociclib + Spartalizumab Fulvestrant Ribociclib Spartalizumab 0 1
Gemcitabine + Ribociclib Gemcitabine Ribociclib 0 2
Goserelin + Letrozole + Ribociclib Goserelin Letrozole Ribociclib 0 0
Goserelin + Ribociclib Goserelin Ribociclib 0 1
H3B-5942 + Ribociclib H3B-5942 Ribociclib 0 0
HDM201 + Ribociclib HDM201 Ribociclib 0 1
JQ1 + Ribociclib JQ1 Ribociclib 2 0
Letrozole + Ribociclib Letrozole Ribociclib 1 6
LSZ 102 + Ribociclib LSZ 102 Ribociclib 0 1
LXH 254 + Ribociclib LXH 254 Ribociclib 0 1
Mercaptopurine + Ribociclib Mercaptopurine Ribociclib 2 0
Methotrexate + Ribociclib Methotrexate Ribociclib 2 0
Nazartinib + Ribociclib Nazartinib Ribociclib 0 1
Paclitaxel + Ribociclib Paclitaxel Ribociclib 0 1
Prednisolone + Ribociclib Prednisolone Ribociclib 2 0
Ribociclib Ribociclib 6 19
Ribociclib + Sonidegib Ribociclib Sonidegib 0 1
Ribociclib + Spartalizumab Ribociclib Spartalizumab 0 1
Ribociclib + Tamoxifen Ribociclib Tamoxifen 0 1
Ribociclib + Trametinib Ribociclib Trametinib 0 2