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Drug Name Capivasertib
Trade Name
Synonyms AZD5363
Drug Descriptions

Capivasertib (AZD5363) decreases PI3K/AKT/mTOR signaling by inhibition of AKT1, AKT2, and AKT3, resulting in decreased cell proliferation (PMID: 22294718, PMID: 32532747, PMID: 32312891).

DrugClasses Akt Inhibitor (Pan) 18

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + Capivasertib Abiraterone Capivasertib 0 2
AMG 510 + Capivasertib AMG 510 Capivasertib 0 0
Anastrozole + Capivasertib Anastrozole Capivasertib 0 0
AZD1897 + Capivasertib AZD1897 Capivasertib 1 0
AZD4547 + Capivasertib AZD4547 Capivasertib 1 0
Capivasertib Capivasertib 35 3
Capivasertib + Docetaxel + Prednisone Capivasertib Docetaxel Prednisone 1 0
Capivasertib + Durvalumab + Paclitaxel Capivasertib Durvalumab Paclitaxel 0 1
Capivasertib + Enzalutamide Capivasertib Enzalutamide 1 2
Capivasertib + Fulvestrant Capivasertib Fulvestrant 1 2
Capivasertib + Olaparib Capivasertib Olaparib 4 2
Capivasertib + Paclitaxel Capivasertib Paclitaxel 5 2
Capivasertib + Tamoxifen Capivasertib Tamoxifen 1 0


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