Drug Detail


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Drug Name Capivasertib
Trade Name
Synonyms AZD5363|AZD 5363|AZD-5363
Drug Descriptions

Capivasertib (AZD5363) decreases PI3K/AKT/mTOR signaling by inhibition of AKT1, AKT2, and AKT3, potentially resulting in decreased cell proliferation (PMID: 22294718, PMID: 32532747, PMID: 32312891).

DrugClasses Akt Inhibitor (Pan) 21
CAS Registry Number 1143532-39-1
NCIT ID C102564


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + Capivasertib Abiraterone Capivasertib 0 2
Anastrozole + Capivasertib Anastrozole Capivasertib 0 0
AZD1897 + Capivasertib AZD1897 Capivasertib 0 0
AZD4547 + Capivasertib AZD4547 Capivasertib 0 0
Capivasertib Capivasertib 20 6
Capivasertib + Docetaxel Capivasertib Docetaxel 0 1
Capivasertib + Docetaxel + Prednisone Capivasertib Docetaxel Prednisone 0 0
Capivasertib + Durvalumab + Paclitaxel Capivasertib Durvalumab Paclitaxel 0 1
Capivasertib + Enzalutamide Capivasertib Enzalutamide 0 2
Capivasertib + Fulvestrant Capivasertib Fulvestrant 0 2
Capivasertib + Fulvestrant + Lapatinib Capivasertib Fulvestrant Lapatinib 0 0
Capivasertib + Fulvestrant + Palbociclib Capivasertib Fulvestrant Palbociclib 0 1
Capivasertib + Midazolam Capivasertib Midazolam 0 1
Capivasertib + Olaparib Capivasertib Olaparib 0 2
Capivasertib + Paclitaxel Capivasertib Paclitaxel 4 2
Capivasertib + Sotorasib Capivasertib Sotorasib 0 0
Capivasertib + Tamoxifen Capivasertib Tamoxifen 1 0
Capivasertib + Trastuzumab deruxtecan Capivasertib Trastuzumab deruxtecan 0 1

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