Drug Detail

Drug Name Abemaciclib
Trade Name Verzenio
Synonyms LY2835219
Drug Descriptions

Verzenio (abemaciclib) is a dual CDK4/6 inhibitor, which inhibits Rb1 protein phosphorylation and may induce cell cycle arrest and prevent growth in cancer cells (PMID: 24919854). Verzenio (abemaciclib) is FDA approved as a monotherapy and in combination with Faslodex (fulvestrant) in patients with hormone receptor-positive (ESR, PGR) and ERBB2 (HER2) receptor-negative advanced or metastatic breast cancer (FDA.gov).

DrugClasses CDK4/6 Inhibitor 8

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib Abemaciclib 14 23
Abemaciclib + Abiraterone + Prednisone Abemaciclib Abiraterone Prednisone 0 1
Abemaciclib + Anastrozole Abemaciclib Anastrozole 0 1
Abemaciclib + Anastrozole + Letrozole Abemaciclib Anastrozole Letrozole 0 1
Abemaciclib + Anastrozole + Xentuzumab Abemaciclib Anastrozole Xentuzumab 0 1
Abemaciclib + Clarithromycin Abemaciclib Clarithromycin 0 1
Abemaciclib + Dexamethasone + Ixazomib + Pomalidomide Abemaciclib Dexamethasone Ixazomib Pomalidomide 0 1
Abemaciclib + Everolimus Abemaciclib Everolimus 1 0
Abemaciclib + Everolimus + Exemestane Abemaciclib Everolimus Exemestane 0 1
Abemaciclib + Exemestane Abemaciclib Exemestane 0 1
Abemaciclib + Fulvestrant Abemaciclib Fulvestrant 0 2
Abemaciclib + Fulvestrant + LY3023414 Abemaciclib Fulvestrant LY3023414 0 1
Abemaciclib + Fulvestrant + Trastuzumab Abemaciclib Fulvestrant Trastuzumab 0 1
Abemaciclib + Fulvestrant + Xentuzumab Abemaciclib Fulvestrant Xentuzumab 0 1
Abemaciclib + Galunisertib Abemaciclib Galunisertib 0 1
Abemaciclib + Gemcitabine Abemaciclib Gemcitabine 1 0
Abemaciclib + H3B-5942 Abemaciclib H3B-5942 0 0
Abemaciclib + Lapatinib Abemaciclib Lapatinib 1 0
Abemaciclib + Letrozole Abemaciclib Letrozole 0 1
Abemaciclib + Letrozole + LY3023414 Abemaciclib LY3023414 Letrozole 0 1
Abemaciclib + Letrozole + Xentuzumab Abemaciclib Letrozole Xentuzumab 0 1
Abemaciclib + Loperamide Abemaciclib Loperamide 0 1
Abemaciclib + Loperamide + Pertuzumab + Trastuzumab Abemaciclib Loperamide Pertuzumab Trastuzumab 0 1
Abemaciclib + LY3023414 Abemaciclib LY3023414 0 2
Abemaciclib + LY3039478 Abemaciclib LY3039478 0 1
Abemaciclib + LY3214996 Abemaciclib LY3214996 0 1
Abemaciclib + Nivolumab Abemaciclib Nivolumab 0 2
Abemaciclib + Pembrolizumab Abemaciclib Pembrolizumab 0 1
Abemaciclib + Pemetrexed Abemaciclib Pemetrexed 1 0
Abemaciclib + Ramucirumab Abemaciclib Ramucirumab 1 1
Abemaciclib + Sunitinib Abemaciclib Sunitinib 0 1
Abemaciclib + Tamoxifen Abemaciclib Tamoxifen 0 2
Abemaciclib + Temozolomide Abemaciclib Temozolomide 0 1
Abemaciclib + Torin 2 Abemaciclib Torin 2 1 0
Abemaciclib + Trastuzumab Abemaciclib Trastuzumab 1 2
Abemaciclib + Trastuzumab + Tucatinib Abemaciclib Trastuzumab Tucatinib 0 1
Abemaciclib + Xentuzumab Abemaciclib Xentuzumab 0 1