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Drug Name Abemaciclib
Trade Name Verzenio
Synonyms LY2835219
Drug Descriptions

Verzenio (abemaciclib) is a dual CDK4/6 inhibitor, which inhibits Rb1 protein phosphorylation and may induce cell cycle arrest and prevent growth in cancer cells (PMID: 24919854). Verzenio (abemaciclib) is FDA approved as a monotherapy and in combination with Faslodex (fulvestrant) in patients with hormone receptor-positive, ERBB2 (HER2) receptor-negative advanced or metastatic breast cancer, in combination with endocrine therapy as adjuvant treatment for patients with hormone receptor-positive, ERBB2 (HER2) receptor-negative, node-positive, early breast cancer at high risk of recurrence, and in combination with an aromatase inhibitor as initial therapy for patients with hormone receptor-positive, ERBB2 (HER2) receptor-negative advanced or metastatic breast cancer (FDA.gov).

DrugClasses CDK4/6 Inhibitor 13
CAS Registry Number 1231930-82-7
NCIT ID C97660

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib Abemaciclib 4 58
Abemaciclib + Abiraterone + Prednisone Abemaciclib Abiraterone Prednisone 0 2
Abemaciclib + Ado-trastuzumab emtansine Abemaciclib Ado-trastuzumab emtansine 0 1
Abemaciclib + Amcenestrant Abemaciclib Amcenestrant 0 2
Abemaciclib + Anastrozole Abemaciclib Anastrozole 0 11
Abemaciclib + Anastrozole + Degarelix Abemaciclib Anastrozole Degarelix 0 1
Abemaciclib + Anastrozole + Durvalumab Abemaciclib Anastrozole Durvalumab 0 1
Abemaciclib + Anastrozole + Fulvestrant Abemaciclib Anastrozole Fulvestrant 0 1
Abemaciclib + Anastrozole + Hydroxychloroquine Abemaciclib Anastrozole Hydroxychloroquine 0 1
Abemaciclib + Anastrozole + Letrozole Abemaciclib Anastrozole Letrozole 0 1
Abemaciclib + Anastrozole + LOXO-783 Abemaciclib Anastrozole LOXO-783 0 1
Abemaciclib + Anastrozole + LY3484356 Abemaciclib Anastrozole LY3484356 0 1
Abemaciclib + Anastrozole + Nivolumab Abemaciclib Anastrozole Nivolumab 0 0
Abemaciclib + Anastrozole + Xentuzumab Abemaciclib Anastrozole Xentuzumab 0 1
Abemaciclib + ARTS-021 + Fulvestrant ARTS-021 Abemaciclib Fulvestrant 0 0
Abemaciclib + ARTS-021 + Letrozole ARTS-021 Abemaciclib Letrozole 0 0
Abemaciclib + Atezolizumab Abemaciclib Atezolizumab 0 2
Abemaciclib + AZD8421 + Camizestrant AZD8421 Abemaciclib Camizestrant 0 1
Abemaciclib + Belzutifan Abemaciclib Belzutifan 0 1
Abemaciclib + Bevacizumab Abemaciclib Bevacizumab 0 1
Abemaciclib + Bicalutamide Abemaciclib Bicalutamide 0 1
Abemaciclib + Camizestrant Abemaciclib Camizestrant 0 2
Abemaciclib + Capivasertib + Fulvestrant Abemaciclib Capivasertib Fulvestrant 0 1
Abemaciclib + CB-103 Abemaciclib CB-103 0 1
Abemaciclib + Cetuximab + LY3214996 Abemaciclib Cetuximab LY3214996 0 1
Abemaciclib + Clarithromycin Abemaciclib Clarithromycin 0 1
Abemaciclib + Copanlisib + Fulvestrant Abemaciclib Copanlisib Fulvestrant 0 1
Abemaciclib + Darolutamide Abemaciclib Darolutamide 0 1
Abemaciclib + Darolutamide + Degarelix + Goserelin + Leuprolide Abemaciclib Darolutamide Degarelix Goserelin Leuprolide 0 1
Abemaciclib + Dexamethasone + Ixazomib + Pomalidomide Abemaciclib Dexamethasone Ixazomib Pomalidomide 0 1
Abemaciclib + Durvalumab + Exemestane Abemaciclib Durvalumab Exemestane 0 1
Abemaciclib + Durvalumab + Letrozole Abemaciclib Durvalumab Letrozole 0 1
Abemaciclib + Elacestrant Abemaciclib Elacestrant 0 4
Abemaciclib + Enobosarm Abemaciclib Enobosarm 0 1
Abemaciclib + Everolimus Abemaciclib Everolimus 0 0
Abemaciclib + Everolimus + Exemestane Abemaciclib Everolimus Exemestane 0 1
Abemaciclib + Exemestane Abemaciclib Exemestane 0 4
Abemaciclib + Exemestane + LOXO-783 Abemaciclib Exemestane LOXO-783 0 1
Abemaciclib + Exemestane + LY3484356 Abemaciclib Exemestane LY3484356 0 1
Abemaciclib + Fulvestrant Abemaciclib Fulvestrant 0 16
Abemaciclib + Fulvestrant + Hydroxychloroquine Abemaciclib Fulvestrant Hydroxychloroquine 0 1
Abemaciclib + Fulvestrant + Letrozole Abemaciclib Fulvestrant Letrozole 0 1
Abemaciclib + Fulvestrant + LOXO-783 Abemaciclib Fulvestrant LOXO-783 0 1
Abemaciclib + Fulvestrant + Lucitanib Abemaciclib Fulvestrant Lucitanib 0 0
Abemaciclib + Fulvestrant + LY3023414 Abemaciclib Fulvestrant LY3023414 0 1
Abemaciclib + Fulvestrant + RLY-5836 Abemaciclib Fulvestrant RLY-5836 0 1
Abemaciclib + Fulvestrant + RO5126766 Abemaciclib Fulvestrant RO5126766 0 1
Abemaciclib + Fulvestrant + Trastuzumab Abemaciclib Fulvestrant Trastuzumab 0 1
Abemaciclib + Fulvestrant + Xentuzumab Abemaciclib Fulvestrant Xentuzumab 0 1
Abemaciclib + Fulvestrant + Zotatifin Abemaciclib Fulvestrant Zotatifin 0 1
Abemaciclib + Galunisertib Abemaciclib Galunisertib 0 1
Abemaciclib + Gemcitabine Abemaciclib Gemcitabine 0 0
Abemaciclib + Giredestrant Abemaciclib Giredestrant 0 3
Abemaciclib + Goserelin + Letrozole Abemaciclib Goserelin Letrozole 0 1
Abemaciclib + H3B-5942 Abemaciclib H3B-5942 0 0
Abemaciclib + Hydroxychloroquine Abemaciclib Hydroxychloroquine 0 2
Abemaciclib + Hydroxychloroquine + Letrozole Abemaciclib Hydroxychloroquine Letrozole 0 1
Abemaciclib + INX-315 Abemaciclib INX-315 0 0
Abemaciclib + Irinotecan + Temozolomide Abemaciclib Irinotecan Temozolomide 0 3
Abemaciclib + Lapatinib Abemaciclib Lapatinib 0 0
Abemaciclib + Lasofoxifene Abemaciclib Lasofoxifene 0 2
Abemaciclib + Letrozole Abemaciclib Letrozole 0 17
Abemaciclib + Letrozole + Leuprolide Abemaciclib Letrozole Leuprolide 0 1
Abemaciclib + Letrozole + LOXO-783 Abemaciclib LOXO-783 Letrozole 0 1
Abemaciclib + Letrozole + LY3023414 Abemaciclib LY3023414 Letrozole 0 1
Abemaciclib + Letrozole + LY3484356 Abemaciclib LY3484356 Letrozole 0 1
Abemaciclib + Letrozole + Metformin Abemaciclib Letrozole Metformin 0 1
Abemaciclib + Letrozole + Xentuzumab Abemaciclib Letrozole Xentuzumab 0 1
Abemaciclib + Loperamide Abemaciclib Loperamide 0 1
Abemaciclib + Loperamide + Pertuzumab + Trastuzumab Abemaciclib Loperamide Pertuzumab Trastuzumab 0 1
Abemaciclib + LOXO-783 + LY3484356 Abemaciclib LOXO-783 LY3484356 0 1
Abemaciclib + lutetium Lu 177 vipivotide tetraxetan Abemaciclib lutetium Lu 177 vipivotide tetraxetan 0 1
Abemaciclib + LY3023414 Abemaciclib LY3023414 0 2
Abemaciclib + LY3039478 Abemaciclib LY3039478 0 1
Abemaciclib + LY3214996 Abemaciclib LY3214996 1 3
Abemaciclib + LY3484356 Abemaciclib LY3484356 0 2
Abemaciclib + LY3484356 + Trastuzumab Abemaciclib LY3484356 Trastuzumab 0 1
Abemaciclib + LY3499446 Abemaciclib LY3499446 0 1
Abemaciclib + LY3537982 Abemaciclib LY3537982 0 1
Abemaciclib + Niraparib Abemaciclib Niraparib 0 1
Abemaciclib + Nivolumab Abemaciclib Nivolumab 0 3
Abemaciclib + Olaparib Abemaciclib Olaparib 0 1
Abemaciclib + Osimertinib Abemaciclib Osimertinib 0 1
Abemaciclib + Palazestrant Abemaciclib Palazestrant 0 0
Abemaciclib + Pembrolizumab Abemaciclib Pembrolizumab 0 5
Abemaciclib + Pemetrexed Disodium Abemaciclib Pemetrexed Disodium 0 0
Abemaciclib + Ramucirumab Abemaciclib Ramucirumab 0 2
Abemaciclib + Ruxolitinib Abemaciclib Ruxolitinib 0 1
Abemaciclib + SCH772984 Abemaciclib SCH772984 0 0
Abemaciclib + Seviteronel Abemaciclib Seviteronel 0 0
Abemaciclib + Sunitinib Abemaciclib Sunitinib 0 1
Abemaciclib + Tamoxifen Abemaciclib Tamoxifen 0 4
Abemaciclib + Temozolomide Abemaciclib Temozolomide 1 3
Abemaciclib + Torin 2 Abemaciclib Torin 2 0 0
Abemaciclib + Trastuzumab Abemaciclib Trastuzumab 0 2
Abemaciclib + Trastuzumab + Tucatinib Abemaciclib Trastuzumab Tucatinib 0 1
Abemaciclib + unspecified PD-1 antibody Abemaciclib unspecified PD-1 antibody 1 0
Abemaciclib + Vepdegestrant Abemaciclib Vepdegestrant 0 1
Abemaciclib + Xentuzumab Abemaciclib Xentuzumab 0 1
Abemaciclib + ZEN-3694 Abemaciclib ZEN-3694 0 1
Abemaciclib + Ziftomenib Abemaciclib Ziftomenib 0 0
Abemaciclib + ZN-c5 Abemaciclib ZN-c5 0 1


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