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Drug Name LY3023414
Trade Name
Synonyms Samotolisib|LY-3023414|LY 3023414
Drug Descriptions

Samotolisib (LY3023414) is an ATP competitive inhibitor of PI3K/mTOR, inhibits signaling of the PI3K/mTOR pathway, and has demonstrated antiproliferative activity against tumor cells (PMID: 24387334, PMID: 31880826).

DrugClasses mTOR Inhibitor 51 PI3K Inhibitor (Pan) 40
CAS Registry Number 1386874-06-1
NCIT ID C121817

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Fulvestrant + LY3023414 Abemaciclib Fulvestrant LY3023414 0 1
Abemaciclib + Letrozole + LY3023414 Abemaciclib LY3023414 Letrozole 0 1
Abemaciclib + LY3023414 Abemaciclib LY3023414 0 2
Enzalutamide + LY3023414 Enzalutamide LY3023414 0 0
Letrozole + LY3023414 LY3023414 Letrozole 0 1
LY3023414 LY3023414 6 10
LY3023414 + LY3039478 LY3023414 LY3039478 0 1
LY3023414 + LY3214996 LY3023414 LY3214996 0 0
LY3023414 + Midazolam LY3023414 Midazolam 0 1
LY3023414 + Prexasertib LY3023414 Prexasertib 1 1


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