Drug Detail


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Drug Name LY3039478
Trade Name
Synonyms Crenigacestat|LY-3039478|JSMD194
Drug Descriptions

Crenigacestat (LY3039478) is a pan-NOTCH inhibitor, which may limit growth and survival of cancer cells (Cancer Res April 15, 2013 73; 1131, PMID: 32042099).

DrugClasses NOTCH Inhibitor (Pan) 5
CAS Registry Number 1421438-81-4
NCIT ID C121535


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + LY3039478 Abemaciclib LY3039478 0 1
Anti-BCMA CAR T Cells + Cyclophosphamide + Fludarabine + LY3039478 Anti-BCMA CAR T Cells Cyclophosphamide Fludarabine LY3039478 0 1
Carboplatin + Gemcitabine + LY3039478 Carboplatin Gemcitabine LY3039478 0 1
Cisplatin + Gemcitabine + LY3039478 Cisplatin Gemcitabine LY3039478 0 1
Idecabtagene Vicleucel + LY3039478 Idecabtagene Vicleucel LY3039478 0 1
LY3023414 + LY3039478 LY3023414 LY3039478 0 1
LY3039478 LY3039478 1 3
LY3039478 + NSC156529 LY3039478 NSC156529 0 0
LY3039478 + Taladegib LY3039478 Taladegib 0 1

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