Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name LY3039478
Trade Name
Synonyms Crenigacestat|LY-3039478|JSMD194
Drug Descriptions

Crenigacestat (LY3039478) is a pan-NOTCH inhibitor, which may limit growth and survival of cancer cells (Cancer Res April 15, 2013 73; 1131, PMID: 32042099).

DrugClasses NOTCH Inhibitor (Pan) 5
CAS Registry Number 1421438-81-4
NCIT ID C121535


  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"


  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + LY3039478 Abemaciclib LY3039478 0 1
Anti-BCMA CAR T Cells + Cyclophosphamide + Fludarabine + LY3039478 Anti-BCMA CAR T Cells Cyclophosphamide Fludarabine LY3039478 0 1
Carboplatin + Gemcitabine + LY3039478 Carboplatin Gemcitabine LY3039478 0 1
Cisplatin + Gemcitabine + LY3039478 Cisplatin Gemcitabine LY3039478 0 1
Idecabtagene Vicleucel + LY3039478 Idecabtagene Vicleucel LY3039478 0 1
LY3023414 + LY3039478 LY3023414 LY3039478 0 1
LY3039478 LY3039478 1 3
LY3039478 + NSC156529 LY3039478 NSC156529 0 0
LY3039478 + Taladegib LY3039478 Taladegib 0 1

Additional content available in CKB BOOST