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Drug Name Enzalutamide
Trade Name Xtandi
Synonyms MDV3100
Drug Descriptions

Xtandi (enzalutamide) is a second-generation small molecule androgen receptor (AR) inhibitor that inhibits AR signaling, thereby resulting in decreased tumor growth (PMID: 24009414, PMID: 25945058). Xtandi (enzalutamide) is FDA approved for use in patients with castration-resistant prostate cancer and metastatic hormone-sensitive prostate cancer (FDA.gov).

DrugClasses Hormone - Anti-androgens 26

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Therapy Name Drugs Efficacy Evidence Clinical Trials
131I-MIP-1095 + Enzalutamide 131I-MIP-1095 Enzalutamide 0 1
ABC294640 + Enzalutamide ABC294640 Enzalutamide 0 1
Abiraterone + Cabazitaxel + Carboplatin + Enzalutamide + Prednisone Abiraterone Cabazitaxel Carboplatin Enzalutamide Prednisone 0 1
Abiraterone + Denosumab + Enzalutamide + Prednisone Abiraterone Denosumab Enzalutamide Prednisone 0 1
Abiraterone + Docetaxel + Enzalutamide Abiraterone Docetaxel Enzalutamide 0 1
Abiraterone + Enzalutamide + Goserelin + Prednisone Abiraterone Enzalutamide Goserelin Prednisone 0 1
Abiraterone + Enzalutamide + Prednisone Abiraterone Enzalutamide Prednisone 0 1
Abiraterone + Enzalutamide + Radium Ra 223 dichloride Abiraterone Enzalutamide Radium Ra 223 dichloride 0 1
Alpelisib + AZD8186 + Enzalutamide AZD8186 Alpelisib Enzalutamide 0 0
Alpelisib + Enzalutamide Alpelisib Enzalutamide 0 1
Atezolizumab + Enzalutamide Atezolizumab Enzalutamide 0 2
Avelumab + Enzalutamide Avelumab Enzalutamide 0 1
Avelumab + Enzalutamide + NKTR-214 Avelumab Enzalutamide NKTR-214 0 1
AZD5312 + Enzalutamide AZD5312 Enzalutamide 0 1
AZD8186 + Enzalutamide AZD8186 Enzalutamide 0 0
Cabazitaxel + Enzalutamide Cabazitaxel Enzalutamide 0 1
Capivasertib + Enzalutamide Capivasertib Enzalutamide 0 2
Carboplatin + Enzalutamide + Paclitaxel Carboplatin Enzalutamide Paclitaxel 0 1
Carotuximab + Enzalutamide Carotuximab Enzalutamide 0 1
CC-115 + Enzalutamide CC-115 Enzalutamide 0 1
CORT125281 + Enzalutamide CORT125281 Enzalutamide 0 1
CPI-1205 + Enzalutamide CPI-1205 Enzalutamide 0 1
Crizotinib + Enzalutamide Crizotinib Enzalutamide 0 1
CRLX101 + Enzalutamide CRLX101 Enzalutamide 0 1
Decitabine + Enzalutamide Decitabine Enzalutamide 0 1
Degarelix + Enzalutamide Degarelix Enzalutamide 0 1
Denosumab + Enzalutamide Denosumab Enzalutamide 0 1
Docetaxel + Enzalutamide + Prednisone Docetaxel Enzalutamide Prednisone 0 1
Dutasteride + Enzalutamide Dutasteride Enzalutamide 0 1
Entinostat + Enzalutamide Entinostat Enzalutamide 0 1
Enzalutamide Enzalutamide 4 76
Enzalutamide + Erdafitinib Enzalutamide Erdafitinib 0 1
Enzalutamide + Everolimus Enzalutamide Everolimus 0 1
Enzalutamide + Exemestane Enzalutamide Exemestane 0 2
Enzalutamide + Fulvestrant Enzalutamide Fulvestrant 0 2
Enzalutamide + G1T38 Enzalutamide G1T38 0 0
Enzalutamide + GSK525762 Enzalutamide GSK525762 0 1
Enzalutamide + Indomethacin Enzalutamide Indomethacin 0 1
Enzalutamide + Leuprolide Enzalutamide Leuprolide 0 1
Enzalutamide + MEDI3726 Enzalutamide MEDI3726 0 1
Enzalutamide + Metformin Enzalutamide Metformin 0 1
Enzalutamide + MI-503 Enzalutamide MI-503 0 0
Enzalutamide + Niclosamide Enzalutamide Niclosamide 0 1
Enzalutamide + Nivolumab Enzalutamide Nivolumab 0 1
Enzalutamide + ORIC-101 Enzalutamide ORIC-101 0 1
Enzalutamide + Paclitaxel Enzalutamide Paclitaxel 0 2
Enzalutamide + Pembrolizumab Enzalutamide Pembrolizumab 0 6
Enzalutamide + PF-06952229 Enzalutamide PF-06952229 0 1
Enzalutamide + PROSTVAC-F/TRICOM Enzalutamide PROSTVAC-F/TRICOM 0 0
Enzalutamide + PROSTVAC-F/TRICOM + PROSTVAC-V/TRICOM Enzalutamide PROSTVAC-F/TRICOM PROSTVAC-V/TRICOM 0 1
Enzalutamide + PROSTVAC-V/TRICOM Enzalutamide PROSTVAC-V/TRICOM 0 0
Enzalutamide + Radium Ra 223 dichloride Enzalutamide Radium Ra 223 dichloride 0 3
Enzalutamide + Relacorilant Enzalutamide Relacorilant 0 1
Enzalutamide + Rucaparib Enzalutamide Rucaparib 0 1
Enzalutamide + Tanespimycin Enzalutamide Tanespimycin 0 0
Enzalutamide + Taselisib Enzalutamide Taselisib 0 1
Enzalutamide + Tazemetostat Enzalutamide Tazemetostat 0 1
Enzalutamide + Testosterone Enzalutamide Testosterone 0 1
Enzalutamide + Tivozanib Enzalutamide Tivozanib 0 1
Enzalutamide + Trastuzumab Enzalutamide Trastuzumab 0 1
Enzalutamide + Venetoclax Enzalutamide Venetoclax 0 1
Enzalutamide + ZEN003694 Enzalutamide ZEN003694 0 2


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