Drug Detail


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Drug Name ABC294640
Trade Name
Synonyms Yeliva|Opaganib|ABC-294640|ABC 294640
Drug Descriptions

Yeliva (ABC294640) is a selective inhibitor of sphingokinase 2 (SK2), which results in decreased SK2 activity, leading to reduced cell signaling and tumor cell growth (PMID: 26271487, PMID: 32626514, PMID: 32670862).

CAS Registry Number 915385-81-8
NCIT ID C98278


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Therapy Name Drugs Efficacy Evidence Clinical Trials
ABC294640 ABC294640 0 4
ABC294640 + Abiraterone ABC294640 Abiraterone 0 1
ABC294640 + Enzalutamide ABC294640 Enzalutamide 0 1
ABC294640 + Gemcitabine ABC294640 Gemcitabine 0 0

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