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Drug Name Carotuximab
Trade Name
Synonyms TRC105|TRC-105
Drug Descriptions

Carotuximab (TRC105) is a monoclonal antibody that binds to endoglin, a TGF beta-1 accessory receptor highly expressed on tumor vessel endothelial cells, blocking signaling essential for angiogenesis and potentially decreasing proliferation of tumor cells (NCI Drug Dictionary).

DrugClasses TGFBR inhibitor (pan) 2

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + Carotuximab Abiraterone Carotuximab 0 1
Axitinib + Carotuximab Axitinib Carotuximab 1 1
Bevacizumab + Carotuximab Bevacizumab Carotuximab 1 4
Capecitabine + Carotuximab Capecitabine Carotuximab 0 1
Carotuximab Carotuximab 0 3
Carotuximab + Enzalutamide Carotuximab Enzalutamide 0 1
Carotuximab + Everolimus + Letrozole Carotuximab Everolimus Letrozole 0 1
Carotuximab + Nivolumab Carotuximab Nivolumab 0 1
Carotuximab + Pazopanib Carotuximab Pazopanib 2 3
Carotuximab + Sorafenib Carotuximab Sorafenib 0 2


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