Drug Detail


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Drug Name Carotuximab
Trade Name
Synonyms TRC105|TRC-105|TRC 105
Drug Descriptions

Carotuximab (TRC105) is a monoclonal antibody that binds to endoglin (CD105), a TGF beta-1 accessory receptor highly expressed on tumor vessel endothelial cells, blocking signaling essential for angiogenesis and potentially decreasing proliferation of tumor cells (PMID: 28465443).

DrugClasses TGFBR inhibitor (pan) 2
CAS Registry Number 1268714-50-6
NCIT ID C74010


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + Carotuximab Abiraterone Carotuximab 0 1
Apalutamide + Carotuximab Apalutamide Carotuximab 0 1
Axitinib + Carotuximab Axitinib Carotuximab 0 1
Bevacizumab + Carotuximab Bevacizumab Carotuximab 0 4
Capecitabine + Carotuximab Capecitabine Carotuximab 0 1
Carotuximab Carotuximab 0 3
Carotuximab + Enzalutamide Carotuximab Enzalutamide 0 1
Carotuximab + Everolimus + Letrozole Carotuximab Everolimus Letrozole 0 1
Carotuximab + Nivolumab Carotuximab Nivolumab 0 1
Carotuximab + Osimertinib Carotuximab Osimertinib 0 1
Carotuximab + Pazopanib Carotuximab Pazopanib 0 3
Carotuximab + Sorafenib Carotuximab Sorafenib 0 2

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