Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Apalutamide
Trade Name Erleada
Synonyms ARN-509|JNJ-56021927
Drug Descriptions

Erleada (apalutamide) is a second-generation antiandgrogen, that binds to the androgen receptor (AR) and inhibits downstream signaling, potentially resulting in decreased growth of AR-expressing tumors (PMID: 22266222, PMID: 23337756). Erleada (apalutamide) is FDA approved for use in patients with non-metastatic castration-resistant prostate cancer and metastatic castration-sensitive prostate cancer (FDA.gov).

DrugClasses Hormone - Anti-androgens 48
CAS Registry Number 956104-40-8
NCIT ID C92574

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + Apalutamide Abiraterone Apalutamide 0 2
Abiraterone + Apalutamide + Buserelin + Prednisone Abiraterone Apalutamide Buserelin Prednisone 0 1
Abiraterone + Apalutamide + Degarelix + Indomethacin + Prednisone Abiraterone Apalutamide Degarelix Indomethacin Prednisone 0 1
Abiraterone + Apalutamide + Degarelix + Prednisone Abiraterone Apalutamide Degarelix Prednisone 0 2
Abiraterone + Apalutamide + Docetaxel + Prednisone Abiraterone Apalutamide Docetaxel Prednisone 0 1
Abiraterone + Apalutamide + Gonadorelin + Prednisone Abiraterone Apalutamide Gonadorelin Prednisone 0 1
Abiraterone + Apalutamide + Goserelin + Prednisone Abiraterone Apalutamide Goserelin Prednisone 0 1
Abiraterone + Apalutamide + Histrelin acetate + Prednisone Abiraterone Apalutamide Histrelin acetate Prednisone 0 1
Abiraterone + Apalutamide + Indomethacin + Prednisone Abiraterone Apalutamide Indomethacin Prednisone 0 0
Abiraterone + Apalutamide + Leuprolide Abiraterone Apalutamide Leuprolide 0 3
Abiraterone + Apalutamide + Leuprolide + Prednisone Abiraterone Apalutamide Leuprolide Prednisone 0 2
Abiraterone + Apalutamide + Niraparib + Prednisone Abiraterone Apalutamide Niraparib Prednisone 0 1
Abiraterone + Apalutamide + Prednisone Abiraterone Apalutamide Prednisone 0 13
Abiraterone + Apalutamide + Prednisone + Triptorelin Abiraterone Apalutamide Prednisone Triptorelin 0 1
Apalutamide Apalutamide 0 29
Apalutamide + Atezolizumab Apalutamide Atezolizumab 0 1
Apalutamide + Avelumab Apalutamide Avelumab 0 0
Apalutamide + Carotuximab Apalutamide Carotuximab 0 1
Apalutamide + Cetrelimab Apalutamide Cetrelimab 0 2
Apalutamide + Degarelix Apalutamide Degarelix 0 3
Apalutamide + Docetaxel Apalutamide Docetaxel 0 2
Apalutamide + EPI-7386 Apalutamide EPI-7386 0 1
Apalutamide + Everolimus Apalutamide Everolimus 0 1
Apalutamide + golimumab Apalutamide golimumab 0 1
Apalutamide + Gonadorelin + Radiotherapy Apalutamide Gonadorelin Radiotherapy 0 1
Apalutamide + Goserelin Apalutamide Goserelin 0 2
Apalutamide + JNJ-64041809 Apalutamide JNJ-64041809 0 1
Apalutamide + Leuprolide Apalutamide Leuprolide 0 5
Apalutamide + lutetium Lu 177 vipivotide tetraxetan Apalutamide lutetium Lu 177 vipivotide tetraxetan 0 1
Apalutamide + Niraparib Apalutamide Niraparib 0 1
Apalutamide + Sipuleucel-T Apalutamide Sipuleucel-T 0 1
Apalutamide + Triptorelin Apalutamide Triptorelin 0 1


Additional content available in CKB BOOST