Drug Detail


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Drug Name Apalutamide
Trade Name Erleada
Synonyms ARN-509|JNJ-56021927
Drug Descriptions

Erleada (apalutamide) is a second-generation antiandgrogen, that binds to the androgen receptor (AR) and inhibits downstream signaling, potentially resulting in decreased growth of AR-expressing tumors (PMID: 22266222, PMID: 23337756). Erleada (apalutamide) is FDA approved for use in patients with non-metastatic castration-resistant prostate cancer and metastatic castration-sensitive prostate cancer (FDA.gov).

DrugClasses Hormone - Anti-androgens 27


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + Apalutamide Abiraterone Apalutamide 0 2
Abiraterone + Apalutamide + Degarelix + Indomethacin + Prednisone Abiraterone Apalutamide Degarelix Indomethacin Prednisone 0 1
Abiraterone + Apalutamide + Degarelix + Prednisone Abiraterone Apalutamide Degarelix Prednisone 0 1
Abiraterone + Apalutamide + Docetaxel + Prednisone Abiraterone Apalutamide Docetaxel Prednisone 0 1
Abiraterone + Apalutamide + Gonadorelin + Prednisone Abiraterone Apalutamide Gonadorelin Prednisone 0 1
Abiraterone + Apalutamide + Indomethacin + Prednisone Abiraterone Apalutamide Indomethacin Prednisone 0 0
Abiraterone + Apalutamide + Leuprolide Abiraterone Apalutamide Leuprolide 0 3
Abiraterone + Apalutamide + Leuprolide + Prednisone Abiraterone Apalutamide Leuprolide Prednisone 0 1
Abiraterone + Apalutamide + Prednisone Abiraterone Apalutamide Prednisone 0 12
Apalutamide Apalutamide 3 12
Apalutamide + Avelumab Apalutamide Avelumab 0 0
Apalutamide + Degarelix Apalutamide Degarelix 0 1
Apalutamide + Docetaxel Apalutamide Docetaxel 0 2
Apalutamide + Everolimus Apalutamide Everolimus 0 1
Apalutamide + JNJ-63723283 Apalutamide JNJ-63723283 0 1
Apalutamide + JNJ-64041809 Apalutamide JNJ-64041809 0 1
Apalutamide + Leuprolide Apalutamide Leuprolide 0 2
Apalutamide + Niraparib Apalutamide Niraparib 0 1

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