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|Therapy Name||Apalutamide + Leuprolide|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Apalutamide||Erleada||ARN-509|JNJ-56021927||Hormone - Anti-androgens 27||Erleada (apalutamide) is a second-generation antiandgrogen, that binds to the androgen receptor (AR) and inhibits downstream signaling, potentially resulting in decreased growth of AR-expressing tumors (PMID: 22266222, PMID: 23337756). Erleada (apalutamide) is FDA approved for use in patients with non-metastatic castration-resistant prostate cancer and metastatic castration-sensitive prostate cancer (FDA.gov).|
|Leuprolide||Lupron||Leuprorelin||Lupron (leuprolide) is an agonist of gonadotropin releasing hormone (GnRH), which results decreased testosterone production in males and decreased estradiol production in females, potentially leading to decreased growth of androgen-positive tumors (NCI Drug Dictionary).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT02811809||Phase II||Leuprolide Apalutamide + Leuprolide||Apalutamide Plus Intermittent Hormone Therapy Versus Intermittent Hormone Therapy Alone in Prostate Cancer||Withdrawn|
|NCT02770391||Phase II||Apalutamide + Leuprolide||ARN-509 and Leuprolide in Intermediate and High-risk Prostate Cancer||Recruiting|