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Drug Name Avelumab
Trade Name Bavencio
Synonyms MSB0010718C
Drug Descriptions

Bavencio (avelumab) is a monoclonal antibody binds to human immunosuppressive ligand programmed death-ligand 1 (PD-L1, CD274) and blocks protein signaling, resulting in immune regulation and antitumor immunity (PMID: 26014098). Bavencio (avelumab) is FDA-approved for use in adult and pediatric patients of 12 years or older with metastatic Merkel cell carcinoma, as maintenance therapy in locally advanced or metastatic urothelial carcinoma (UC), in locally advanced or metastatic UC that progressed following chemotherapy, and in combination with axitinib as first-line therapy in advanced renal cell carcinoma (FDA.gov).

DrugClasses Immune Checkpoint Inhibitor 135 PD-L1/PD-1 antibody 79
CAS Registry Number 1537032-82-8
NCIT ID C116870

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + Avelumab Abiraterone Avelumab 0 1
Ad-CEA vaccine + Avelumab + Bevacizumab + Capecitabine Ad-CEA vaccine Avelumab Bevacizumab Capecitabine 0 1
Ad-CEA vaccine + Avelumab + Bevacizumab + Capecitabine + Fluorouracil + Leucovorin + Oxaliplatin Ad-CEA vaccine Avelumab Bevacizumab Capecitabine Fluorouracil Leucovorin Oxaliplatin 0 1
Aldoxorubicin + ALT-803 + Avelumab + Bevacizumab + Capecitabine + Cyclophosphamide + ETBX-011 + ETBX-021 + ETBX-051 + ETBX-061 + Fluorouracil + Gemcitabine + GI-4000 + GI-6207 + GI-6301 + haNK cells + Leucovorin + Nab-paclitaxel + Oxaliplatin ALT-803 Aldoxorubicin Avelumab Bevacizumab Capecitabine Cyclophosphamide ETBX-011 ETBX-021 ETBX-051 ETBX-061 Fluorouracil GI-4000 GI-6207 GI-6301 Gemcitabine Leucovorin Nab-paclitaxel Oxaliplatin haNK cells 0 2
Aldoxorubicin + ALT-803 + Avelumab + Capecitabine + Cetuximab + Cyclophosphamide + ETBX-011 + ETBX-021 + ETBX-051 + ETBX-061 + Fluorouracil + GI-4000 + GI-6207 + GI-6301 + haNK cells + Leucovorin + Nab-paclitaxel + Oxaliplatin + Regorafenib + Trastuzumab ALT-803 Aldoxorubicin Avelumab Capecitabine Cetuximab Cyclophosphamide ETBX-011 ETBX-021 ETBX-051 ETBX-061 Fluorouracil GI-4000 GI-6207 GI-6301 Leucovorin Nab-paclitaxel Oxaliplatin Regorafenib Trastuzumab haNK cells 0 1
Aldoxorubicin + ALT-803 + Avelumab + Capecitabine + Cetuximab + Cyclophosphamide + ETBX-011 + ETBX-051 + ETBX-061 + Fluorouracil + GI-4000 + GI-6207 + GI-6301 + haNK cells + Leucovorin + Nab-paclitaxel + Sorafenib ALT-803 Aldoxorubicin Avelumab Capecitabine Cetuximab Cyclophosphamide ETBX-011 ETBX-051 ETBX-061 Fluorouracil GI-4000 GI-6207 GI-6301 Leucovorin Nab-paclitaxel Sorafenib haNK cells 0 1
Aldoxorubicin + ALT-803 + Avelumab + Cetuximab + ETBX-051 + ETBX-061 + GI-6301 + haNK cells ALT-803 Aldoxorubicin Avelumab Cetuximab ETBX-051 ETBX-061 GI-6301 haNK cells 0 1
Aldoxorubicin + ALT-803 + Avelumab + Cisplatin + Cyclophosphamide + ETBX-011 + ETBX-051 + ETBX-061 + Fluorouracil + GI-4000 + GI-6301 + haNK cells + Paclitaxel ALT-803 Aldoxorubicin Avelumab Cisplatin Cyclophosphamide ETBX-011 ETBX-051 ETBX-061 Fluorouracil GI-4000 GI-6301 Paclitaxel haNK cells 0 1
Aldoxorubicin + ALT-803 + Avelumab + Cyclophosphamide + ETBX-011 + ETBX-051 + ETBX-061 + Fluorouracil + GI-4000 + GI-6207 + GI-6301 + haNK cells + Leucovorin + Nab-paclitaxel ALT-803 Aldoxorubicin Avelumab Cyclophosphamide ETBX-011 ETBX-051 ETBX-061 Fluorouracil GI-4000 GI-6207 GI-6301 Leucovorin Nab-paclitaxel haNK cells 0 1
ALT-803 + Avelumab + Bevacizumab + ETBX-011 + GI-4000 ALT-803 Avelumab Bevacizumab ETBX-011 GI-4000 0 1
ALT-803 + Avelumab + haNK cells ALT-803 Avelumab haNK cells 0 1
Apalutamide + Avelumab Apalutamide Avelumab 0 0
Atezolizumab + Avelumab + Durvalumab + Nivolumab + Pembrolizumab Atezolizumab Avelumab Durvalumab Nivolumab Pembrolizumab 0 1
Atezolizumab + Avelumab + Durvalumab + Nivolumab + Pembrolizumab + Plinabulin Atezolizumab Avelumab Durvalumab Nivolumab Pembrolizumab Plinabulin 0 1
AVB-S6-500 + Avelumab AVB-S6-500 Avelumab 0 1
Avelumab Avelumab 2 61
Avelumab + Axitinib Avelumab Axitinib 0 6
Avelumab + Axitinib + Palbociclib Avelumab Axitinib Palbociclib 0 1
Avelumab + Azacitidine Avelumab Azacitidine 0 2
Avelumab + Azacitidine + PF-04518600 Avelumab Azacitidine PF-04518600 0 1
Avelumab + Azacitidine + Utomilumab Avelumab Azacitidine Utomilumab 0 1
Avelumab + BCG solution Avelumab BCG solution 0 1
Avelumab + Bendamustine + Rituximab Avelumab Bendamustine Rituximab 0 1
Avelumab + Berzosertib Avelumab Berzosertib 0 1
Avelumab + Berzosertib + Carboplatin Avelumab Berzosertib Carboplatin 0 1
Avelumab + Berzosertib + Carboplatin + Gemcitabine Avelumab Berzosertib Carboplatin Gemcitabine 0 1
Avelumab + Bevacizumab + Epacadostat Avelumab Bevacizumab Epacadostat 0 0
Avelumab + Binimetinib Avelumab Binimetinib 0 2
Avelumab + Binimetinib + Talazoparib Avelumab Binimetinib Talazoparib 0 1
Avelumab + Cabozantinib Avelumab Cabozantinib 0 1
Avelumab + Capecitabine Avelumab Capecitabine 0 1
Avelumab + Carboplatin + Etoposide + Ifosfamide + Rituximab + Utomilumab Avelumab Carboplatin Etoposide Ifosfamide Rituximab Utomilumab 0 1
Avelumab + Carboplatin + Gemcitabine Avelumab Carboplatin Gemcitabine 0 3
Avelumab + Carboplatin + Paclitaxel + Talazoparib Avelumab Carboplatin Paclitaxel Talazoparib 0 1
Avelumab + Carboplatin + Pemetrexed Disodium Avelumab Carboplatin Pemetrexed Disodium 0 1
Avelumab + Cetuximab Avelumab Cetuximab 0 1
Avelumab + Cetuximab + Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin Avelumab Cetuximab Fluorouracil Irinotecan Leucovorin Oxaliplatin 0 1
Avelumab + Cetuximab + Irinotecan Avelumab Cetuximab Irinotecan 0 1
Avelumab + Cetuximab + Palbociclib Avelumab Cetuximab Palbociclib 0 1
Avelumab + Cisplatin Avelumab Cisplatin 0 1
Avelumab + Cisplatin + Doxorubicin + Methotrexate + Vinblastine Avelumab Cisplatin Doxorubicin Methotrexate Vinblastine 0 1
Avelumab + Cisplatin + Fluorouracil + Mitomycin C Avelumab Cisplatin Fluorouracil Mitomycin C 0 1
Avelumab + Cisplatin + Gemcitabine Avelumab Cisplatin Gemcitabine 0 4
Avelumab + Cofetuzumab pelidotin Avelumab Cofetuzumab pelidotin 0 1
Avelumab + Cyclophosphamide Avelumab Cyclophosphamide 0 1
Avelumab + Cyclophosphamide + JX-594 Avelumab Cyclophosphamide JX-594 0 1
Avelumab + Cyclophosphamide + TRX518 Avelumab Cyclophosphamide TRX518 0 1
Avelumab + Darolutamide Avelumab Darolutamide 0 0
Avelumab + DCC-3014 Avelumab DCC-3014 0 1
Avelumab + Debio 1143 Avelumab Debio 1143 0 1
Avelumab + Decitabine Avelumab Decitabine 0 1
Avelumab + Docetaxel Avelumab Docetaxel 0 1
Avelumab + Domatinostat Avelumab Domatinostat 0 2
Avelumab + Eftilagimod alpha Avelumab Eftilagimod alpha 0 1
Avelumab + Entinostat Avelumab Entinostat 0 1
Avelumab + Enzalutamide Avelumab Enzalutamide 0 1
Avelumab + Enzalutamide + NKTR-214 Avelumab Enzalutamide NKTR-214 0 1
Avelumab + Eribulin Avelumab Eribulin 0 1
Avelumab + FH-MCVA2TCR Avelumab FH-MCVA2TCR 0 1
Avelumab + Fluorouracil + Leucovorin + Oxaliplatin + Trastuzumab Avelumab Fluorouracil Leucovorin Oxaliplatin Trastuzumab 0 1
Avelumab + FT516 Avelumab FT516 0 1
Avelumab + Fulvestrant + Palbociclib Avelumab Fulvestrant Palbociclib 0 1
Avelumab + Gemcitabine + Hydroxychloroquine + Nab-paclitaxel Avelumab Gemcitabine Hydroxychloroquine Nab-paclitaxel 0 1
Avelumab + Gemcitabine + Paclitaxel Avelumab Gemcitabine Paclitaxel 0 1
Avelumab + GEN-001 Avelumab GEN-001 0 1
Avelumab + Glasdegib Avelumab Glasdegib 0 1
Avelumab + Hu5F9-G4 Avelumab Hu5F9-G4 0 1
Avelumab + Hydroxychloroquine + Palbociclib Avelumab Hydroxychloroquine Palbociclib 0 0
Avelumab + Ibrutinib + Rituximab + Utomilumab Avelumab Ibrutinib Rituximab Utomilumab 0 1
Avelumab + IDH1 R132H peptide vaccine Avelumab IDH1 R132H peptide vaccine 0 1
Avelumab + Imifoplatin Avelumab Imifoplatin 0 1
Avelumab + KHK2455 Avelumab KHK2455 0 1
Avelumab + Lenvatinib Avelumab Lenvatinib 0 1
Avelumab + Mavelertinib Avelumab Mavelertinib 0 1
Avelumab + Methotrexate Avelumab Methotrexate 0 1
Avelumab + MRx0518 Avelumab MRx0518 0 1
Avelumab + MSC2490484A Avelumab MSC2490484A 0 2
Avelumab + MSC2490484A + Radium Ra 223 dichloride Avelumab MSC2490484A Radium Ra 223 dichloride 0 1
Avelumab + NHS-IL12 Avelumab NHS-IL12 0 1
Avelumab + NKTR-214 Avelumab NKTR-214 0 1
Avelumab + NKTR-214 + Talazoparib Avelumab NKTR-214 Talazoparib 0 1
Avelumab + Paclitaxel + Pelareorep Avelumab Paclitaxel Pelareorep 0 1
Avelumab + Paclitaxel + Ramucirumab Avelumab Paclitaxel Ramucirumab 0 1
Avelumab + Palbociclib Avelumab Palbociclib 0 1
Avelumab + Palbociclib + Tamoxifen Avelumab Palbociclib Tamoxifen 0 1
Avelumab + PD 0360324 Avelumab PD 0360324 0 1
Avelumab + Pemetrexed Disodium Avelumab Pemetrexed Disodium 0 1
Avelumab + Pepinemab Avelumab Pepinemab 0 1
Avelumab + PF-04518600 Avelumab PF-04518600 0 4
Avelumab + PF-04518600 + Rituximab Avelumab PF-04518600 Rituximab 0 1
Avelumab + PF-04518600 + Utomilumab Avelumab PF-04518600 Utomilumab 0 2
Avelumab + PF-06840003 Avelumab PF-06840003 0 0
Avelumab + Regorafenib Avelumab Regorafenib 0 1
Avelumab + rhIL-15 Avelumab rhIL-15 0 2
Avelumab + Rituximab + Utomilumab Avelumab Rituximab Utomilumab 0 2
Avelumab + SNK01 Avelumab SNK01 0 1
Avelumab + TAK-981 Avelumab TAK-981 0 1
Avelumab + Talazoparib Avelumab Talazoparib 0 7
Avelumab + Tamoxifen Avelumab Tamoxifen 0 1
Avelumab + Tipapkinogene sovacivec Avelumab Tipapkinogene sovacivec 0 1
Avelumab + Tomivosertib Avelumab Tomivosertib 0 1
Avelumab + Trabectedin Avelumab Trabectedin 0 1
Avelumab + Trastuzumab Avelumab Trastuzumab 0 1
Avelumab + Trastuzumab + Utomilumab Avelumab Trastuzumab Utomilumab 0 1
Avelumab + Trastuzumab + Utomilumab + Vinorelbine Avelumab Trastuzumab Utomilumab Vinorelbine 0 1
Avelumab + Trastuzumab + Vinorelbine Avelumab Trastuzumab Vinorelbine 0 1
Avelumab + Trilaciclib Avelumab Trilaciclib 0 1
Avelumab + Utomilumab Avelumab Utomilumab 0 4
Avelumab + Valproic acid Avelumab Valproic acid 0 1
Avelumab + VSV-hIFNbeta-NIS Avelumab VSV-hIFNbeta-NIS 0 1
Avelumab + VXM01 Avelumab VXM01 0 1


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