Drug Detail

Drug Name Avelumab
Trade Name Bavencio
Synonyms MSB0010718C
Drug Descriptions

Bavencio (avelumab) is a monoclonal antibody binds to human immunosuppressive ligand programmed death-ligand 1 (PD-L1, CD274) and blocks protein signaling, resulting in immune regulation and antitumor immunity (PMID: 26014098). Bavencio (avelumab) is FDA-approved for use in patients with metastatic Merkel cell carcinoma and urothelial carcinoma, and in combination with axitinib in advanced renal cell carcinoma (FDA.gov).

DrugClasses Immune Checkpoint Inhibitor 99 PD-L1/PD-1 antibody 51

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + Avelumab Abiraterone Avelumab 0 1
Ad-CEA vaccine + Avelumab + Bevacizumab + Capecitabine + Fluorouracil + Leucovorin + Oxaliplatin Ad-CEA vaccine Avelumab Bevacizumab Capecitabine Fluorouracil Leucovorin Oxaliplatin 0 1
Aldoxorubicin + ALT-803 + Avelumab + Bevacizumab + Capecitabine + Cyclophosphamide + ETBX-011 + ETBX-021 + ETBX-051 + ETBX-061 + Fluorouracil + Gemcitabine + GI-4000 + GI-6207 + GI-6301 + haNK cells + Leucovorin + Nab-paclitaxel + Oxaliplatin ALT-803 Aldoxorubicin Avelumab Bevacizumab Capecitabine Cyclophosphamide ETBX-011 ETBX-021 ETBX-051 ETBX-061 Fluorouracil GI-4000 GI-6207 GI-6301 Gemcitabine Leucovorin Nab-paclitaxel Oxaliplatin haNK cells 0 2
Aldoxorubicin + ALT-803 + Avelumab + Capecitabine + Cetuximab + Cyclophosphamide + ETBX-011 + ETBX-021 + ETBX-051 + ETBX-061 + Fluorouracil + GI-4000 + GI-6207 + GI-6301 + haNK cells + Leucovorin + Nab-paclitaxel + Oxaliplatin + Regorafenib + Trastuzumab ALT-803 Aldoxorubicin Avelumab Capecitabine Cetuximab Cyclophosphamide ETBX-011 ETBX-021 ETBX-051 ETBX-061 Fluorouracil GI-4000 GI-6207 GI-6301 Leucovorin Nab-paclitaxel Oxaliplatin Regorafenib Trastuzumab haNK cells 0 1
Aldoxorubicin + ALT-803 + Avelumab + Capecitabine + Cetuximab + Cyclophosphamide + ETBX-011 + ETBX-051 + ETBX-061 + Fluorouracil + GI-4000 + GI-6207 + GI-6301 + haNK cells + Leucovorin + Nab-paclitaxel + Sorafenib ALT-803 Aldoxorubicin Avelumab Capecitabine Cetuximab Cyclophosphamide ETBX-011 ETBX-051 ETBX-061 Fluorouracil GI-4000 GI-6207 GI-6301 Leucovorin Nab-paclitaxel Sorafenib haNK cells 0 1
Aldoxorubicin + ALT-803 + Avelumab + Cetuximab + ETBX-051 + ETBX-061 + GI-6301 + haNK cells ALT-803 Aldoxorubicin Avelumab Cetuximab ETBX-051 ETBX-061 GI-6301 haNK cells 0 1
Aldoxorubicin + ALT-803 + Avelumab + Cisplatin + Cyclophosphamide + ETBX-011 + ETBX-051 + ETBX-061 + Fluorouracil + GI-4000 + GI-6301 + haNK cells + Paclitaxel ALT-803 Aldoxorubicin Avelumab Cisplatin Cyclophosphamide ETBX-011 ETBX-051 ETBX-061 Fluorouracil GI-4000 GI-6301 Paclitaxel haNK cells 0 1
Aldoxorubicin + ALT-803 + Avelumab + Cyclophosphamide + ETBX-011 + ETBX-051 + ETBX-061 + Fluorouracil + GI-4000 + GI-6207 + GI-6301 + haNK cells + Leucovorin + Nab-paclitaxel ALT-803 Aldoxorubicin Avelumab Cyclophosphamide ETBX-011 ETBX-051 ETBX-061 Fluorouracil GI-4000 GI-6207 GI-6301 Leucovorin Nab-paclitaxel haNK cells 0 1
ALT-803 + Avelumab + Bevacizumab + ETBX-011 + GI-4000 ALT-803 Avelumab Bevacizumab ETBX-011 GI-4000 0 1
ALT-803 + Avelumab + haNK cells ALT-803 Avelumab haNK cells 0 1
Apalutamide + Avelumab Apalutamide Avelumab 0 0
Avelumab Avelumab 8 46
Avelumab + Axitinib Avelumab Axitinib 1 4
Avelumab + Axitinib + Palbociclib Avelumab Axitinib Palbociclib 0 1
Avelumab + Azacitidine Avelumab Azacitidine 0 2
Avelumab + Azacitidine + PF-04518600 Avelumab Azacitidine PF-04518600 0 1
Avelumab + Azacitidine + Utomilumab Avelumab Azacitidine Utomilumab 0 1
Avelumab + BCG solution Avelumab BCG solution 0 1
Avelumab + Bendamustine + Rituximab Avelumab Bendamustine Rituximab 0 1
Avelumab + Bevacizumab + Epacadostat Avelumab Bevacizumab Epacadostat 0 1
Avelumab + Binimetinib Avelumab Binimetinib 0 2
Avelumab + Binimetinib + Talazoparib Avelumab Binimetinib Talazoparib 0 1
Avelumab + Cabozantinib Avelumab Cabozantinib 0 1
Avelumab + Carboplatin + Etoposide + Ifosfamide + Rituximab + Utomilumab Avelumab Carboplatin Etoposide Ifosfamide Rituximab Utomilumab 0 1
Avelumab + Carboplatin + Paclitaxel + Talazoparib Avelumab Carboplatin Paclitaxel Talazoparib 0 1
Avelumab + Carboplatin + Pemetrexed Avelumab Carboplatin Pemetrexed 0 1
Avelumab + Carboplatin + VX-970 Avelumab Carboplatin VX-970 0 1
Avelumab + Cetuximab Avelumab Cetuximab 0 1
Avelumab + Cetuximab + Palbociclib Avelumab Cetuximab Palbociclib 0 1
Avelumab + Cisplatin Avelumab Cisplatin 0 2
Avelumab + Cisplatin + Fluorouracil + Mitomycin C Avelumab Cisplatin Fluorouracil Mitomycin C 0 1
Avelumab + Cisplatin + Gemcitabine Avelumab Cisplatin Gemcitabine 0 1
Avelumab + Cyclophosphamide + TRX518 Avelumab Cyclophosphamide TRX518 0 1
Avelumab + Darolutamide Avelumab Darolutamide 0 0
Avelumab + Debio 1143 Avelumab Debio 1143 0 1
Avelumab + Decitabine Avelumab Decitabine 0 1
Avelumab + Docetaxel Avelumab Docetaxel 0 1
Avelumab + Entinostat Avelumab Entinostat 0 1
Avelumab + Enzalutamide Avelumab Enzalutamide 0 1
Avelumab + Eribulin Avelumab Eribulin 0 1
Avelumab + Fluorouracil + Leucovorin + Oxaliplatin + Trastuzumab Avelumab Fluorouracil Leucovorin Oxaliplatin Trastuzumab 0 1
Avelumab + Fulvestrant + Palbociclib Avelumab Fulvestrant Palbociclib 0 1
Avelumab + Gemcitabine + Hydroxychloroquine + Nab-paclitaxel Avelumab Gemcitabine Hydroxychloroquine Nab-paclitaxel 0 1
Avelumab + Glasdegib Avelumab Glasdegib 0 1
Avelumab + Hu5F9-G4 Avelumab Hu5F9-G4 0 1
Avelumab + Ibrutinib + Rituximab + Utomilumab Avelumab Ibrutinib Rituximab Utomilumab 0 1
Avelumab + MSC2490484A Avelumab MSC2490484A 0 1
Avelumab + NHS-IL12 Avelumab NHS-IL12 0 1
Avelumab + Palbociclib + Tamoxifen Avelumab Palbociclib Tamoxifen 0 1
Avelumab + PD 0360324 Avelumab PD 0360324 0 1
Avelumab + Pemetrexed Avelumab Pemetrexed 0 1
Avelumab + PF-04518600 Avelumab PF-04518600 0 4
Avelumab + PF-04518600 + Rituximab Avelumab PF-04518600 Rituximab 0 1
Avelumab + PF-04518600 + Utomilumab Avelumab PF-04518600 Utomilumab 0 2
Avelumab + PF-06647020 Avelumab PF-06647020 0 1
Avelumab + PF-06747775 Avelumab PF-06747775 0 1
Avelumab + PT-112 Avelumab PT-112 0 1
Avelumab + rhIL-15 Avelumab rhIL-15 0 1
Avelumab + Rituximab + Utomilumab Avelumab Rituximab Utomilumab 0 2
Avelumab + Talazoparib Avelumab Talazoparib 0 4
Avelumab + Tamoxifen Avelumab Tamoxifen 0 1
Avelumab + Tomivosertib Avelumab Tomivosertib 0 1
Avelumab + Trabectedin Avelumab Trabectedin 0 1
Avelumab + Trastuzumab Avelumab Trastuzumab 0 1
Avelumab + Trastuzumab + Utomilumab Avelumab Trastuzumab Utomilumab 0 1
Avelumab + Trastuzumab + Utomilumab + Vinorelbine Avelumab Trastuzumab Utomilumab Vinorelbine 0 1
Avelumab + Trastuzumab + Vinorelbine Avelumab Trastuzumab Vinorelbine 0 1
Avelumab + Utomilumab Avelumab Utomilumab 0 4
Avelumab + Valproic acid Avelumab Valproic acid 0 1
Avelumab + VSV-hIFNbeta-NIS Avelumab VSV-hIFNbeta-NIS 0 1
Avelumab + VX15/2503 Avelumab VX15/2503 0 1