Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name PF-04518600
Trade Name
Synonyms PF-8600|PF04518600|Ivuxolimab
Drug Descriptions

PF-04518600 (Ivuxolimab) is an activating monoclonal antibody to TNFRSF4 (OX40, CD134), which mimics the binding of the ligand, TNFSF4 (OX40L, CD252), to stimulate proliferation of T-cells and enhance an anti-tumor response (Journal of Clinical Oncology 34, no. 15_suppl (May 20 2016) 3079-3079).

DrugClasses OX40 Antibody 13
CAS Registry Number 2128729-41-7
NCIT ID C121927


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Avelumab + Azacitidine + PF-04518600 Avelumab Azacitidine PF-04518600 0 1
Avelumab + PF-04518600 Avelumab PF-04518600 0 4
Avelumab + PF-04518600 + Rituximab Avelumab PF-04518600 Rituximab 0 1
Avelumab + PF-04518600 + Utomilumab Avelumab PF-04518600 Utomilumab 0 2
Axitinib + PF-04518600 Axitinib PF-04518600 0 1
Azacitidine + PF-04518600 Azacitidine PF-04518600 0 1
PF-04518600 PF-04518600 0 2
PF-04518600 + Rituximab + Utomilumab PF-04518600 Rituximab Utomilumab 0 1
PF-04518600 + Utomilumab PF-04518600 Utomilumab 0 2

Additional content available in CKB BOOST