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Drug Name PF-04518600
Trade Name
Synonyms PF-8600|PF04518600
Drug Descriptions

PF-04518600 is an activating monoclonal antibody to TNFRSF4 (OX40, CD134), which mimics the binding of the ligand, TNFSF4 (OX40L, CD252), to stimulate proliferation of T-cells and enhance an anti-tumor response (Journal of Clinical Oncology 34, no. 15_suppl (May 20 2016) 3079-3079).

DrugClasses OX40 Antibody 10

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Avelumab + Azacitidine + PF-04518600 Avelumab Azacitidine PF-04518600 0 1
Avelumab + PF-04518600 Avelumab PF-04518600 0 4
Avelumab + PF-04518600 + Rituximab Avelumab PF-04518600 Rituximab 0 1
Avelumab + PF-04518600 + Utomilumab Avelumab PF-04518600 Utomilumab 0 2
Axitinib + PF-04518600 Axitinib PF-04518600 0 1
Azacitidine + PF-04518600 Azacitidine PF-04518600 0 1
PF-04518600 PF-04518600 0 2
PF-04518600 + Rituximab + Utomilumab PF-04518600 Rituximab Utomilumab 0 1
PF-04518600 + Utomilumab PF-04518600 Utomilumab 0 2


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