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Drug Name Rituximab
Trade Name Rituxan
Synonyms IDEC-C2B8|MabThera
Drug Descriptions

Rituxan (rituximab) is a chimeric mononclonal antibody that binds to CD20 on B-cells, resulting in induction of complement-dependent and antibody-dependent cytotoxicity, and potentially leading to decreased B-cell tumor growth (PMID: 28983798). Rituxan (rituximab) is FDA approved for use as monotherapy or in combination with chemotherapy in CD20-positive B-cell non-Hodgkin lymphoma, and in combination with fludarabine and cyclophosphamide in CD20-positive chronic lymphocytic leukemia (FDA.gov).

DrugClasses CD20 Antibody 6

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Acalabrutinib + Bendamustine + Cytarabine + Rituximab Acalabrutinib Bendamustine Cytarabine Rituximab 0 2
Acalabrutinib + Bendamustine + Rituximab Acalabrutinib Bendamustine Rituximab 0 3
Acalabrutinib + Carboplatin + Etoposide + Ifosfamide + Rituximab Acalabrutinib Carboplatin Etoposide Ifosfamide Rituximab 0 2
Acalabrutinib + Cyclophosphamide + Doxorubicin + Etoposide + Prednisone + Rituximab + Vincristine Acalabrutinib Cyclophosphamide Doxorubicin Etoposide Prednisone Rituximab Vincristine 0 1
Acalabrutinib + Cyclophosphamide + Doxorubicin + Prednisone + Rituximab + Vincristine Acalabrutinib Cyclophosphamide Doxorubicin Prednisone Rituximab Vincristine 0 1
Acalabrutinib + Lenalidomide + Rituximab Acalabrutinib Lenalidomide Rituximab 0 1
Acalabrutinib + Rituximab Acalabrutinib Rituximab 0 1
ACTR087 + Rituximab ACTR087 Rituximab 0 1
ACTR707 + Rituximab ACTR707 Rituximab 0 1
Aldesleukin + Cyclophosphamide + Fludarabine + FT516 + Rituximab Aldesleukin Cyclophosphamide FT516 Fludarabine Rituximab 0 1
Aldoxorubicin + Cyclophosphamide + Prednisone + Rituximab + Vincristine Aldoxorubicin Cyclophosphamide Prednisone Rituximab Vincristine 0 1
Alisertib + Bortezomib + Rituximab Alisertib Bortezomib Rituximab 0 1
Alisertib + Rituximab Alisertib Rituximab 1 0
Alisertib + Rituximab + Vincristine Alisertib Rituximab Vincristine 1 0
ALT-803 + Rituximab ALT-803 Rituximab 0 1
anti-thymocyte globulin + Cyclophosphamide + Fludarabine + haNK cells + Rituximab Cyclophosphamide Fludarabine Rituximab anti-thymocyte globulin haNK cells 0 1
anti-thymocyte globulin + Ibritumomab tiuxetan + Rituximab Ibritumomab tiuxetan Rituximab anti-thymocyte globulin 0 1
Atezolizumab + Gemcitabine + Oxaliplatin + Rituximab Atezolizumab Gemcitabine Oxaliplatin Rituximab 0 1
Atezolizumab + Rituximab Atezolizumab Rituximab 0 1
Avelumab + Bendamustine + Rituximab Avelumab Bendamustine Rituximab 0 1
Avelumab + Carboplatin + Etoposide + Ifosfamide + Rituximab + Utomilumab Avelumab Carboplatin Etoposide Ifosfamide Rituximab Utomilumab 0 1
Avelumab + Ibrutinib + Rituximab + Utomilumab Avelumab Ibrutinib Rituximab Utomilumab 0 1
Avelumab + PF-04518600 + Rituximab Avelumab PF-04518600 Rituximab 0 1
Avelumab + Rituximab + Utomilumab Avelumab Rituximab Utomilumab 0 2
Bendamustine + Bortezomib + Rituximab Bendamustine Bortezomib Rituximab 1 0
Bendamustine + Brentuximab vedotin + Rituximab Bendamustine Brentuximab vedotin Rituximab 0 1
Bendamustine + Copanlisib + Rituximab Bendamustine Copanlisib Rituximab 0 1
Bendamustine + CUDC-907 + Rituximab Bendamustine CUDC-907 Rituximab 0 1
Bendamustine + Cytarabine + Rituximab Bendamustine Cytarabine Rituximab 0 1
Bendamustine + Durvalumab + Rituximab Bendamustine Durvalumab Rituximab 0 1
Bendamustine + Idelalisib + Rituximab Bendamustine Idelalisib Rituximab 1 2
Bendamustine + MK2206 + Rituximab Bendamustine MK2206 Rituximab 1 0
Bendamustine + Parsaclisib + Rituximab Bendamustine Parsaclisib Rituximab 0 1
Bendamustine + Polatuzumab vedotin-piiq + Rituximab Bendamustine Polatuzumab vedotin-piiq Rituximab 1 1
Bendamustine + Rituximab Bendamustine Rituximab 2 15
Bendamustine + Rituximab + TAK-659 Bendamustine Rituximab TAK-659 0 1
Bendamustine + Rituximab + Veliparib Bendamustine Rituximab Veliparib 2 0
Bendamustine + Rituximab + Venetoclax Bendamustine Rituximab Venetoclax 0 3
Betalutin + Rituximab Betalutin Rituximab 0 0
BI-1206 + Rituximab BI-1206 Rituximab 0 1
Bortezomib + Cladribine + Rituximab Bortezomib Cladribine Rituximab 0 1
Bortezomib + Rituximab Bortezomib Rituximab 0 2
Bortezomib + Rituximab + Venetoclax Bortezomib Rituximab Venetoclax 0 1
Brentuximab vedotin + Cyclophosphamide + Doxorubicin + Prednisone + Rituximab Brentuximab vedotin Cyclophosphamide Doxorubicin Prednisone Rituximab 0 1
Brentuximab vedotin + Doxorubicin + Rituximab + Vincristine Brentuximab vedotin Doxorubicin Rituximab Vincristine 0 1
Brentuximab vedotin + Rituximab Brentuximab vedotin Rituximab 0 1
Buparlisib + Rituximab Buparlisib Rituximab 0 1
Busulfan + Clofarabine + Cyclophosphamide + Gemcitabine + Mycophenolate mofetil + Rituximab + Tacrolimus + Vorinostat Busulfan Clofarabine Cyclophosphamide Gemcitabine Mycophenolate mofetil Rituximab Tacrolimus Vorinostat 0 1
Carboplatin + Copanlisib + Dexamethasone + Gemcitabine + Pegfilgrastim + Rituximab Carboplatin Copanlisib Dexamethasone Gemcitabine Pegfilgrastim Rituximab 0 1
Carboplatin + Dexamethasone + Etoposide + Ifosfamide + Rituximab Carboplatin Dexamethasone Etoposide Ifosfamide Rituximab 0 1
Carboplatin + Dexamethasone + Idarubicin + Ifosfamide + Rituximab + Vincristine Carboplatin Dexamethasone Idarubicin Ifosfamide Rituximab Vincristine 0 1
Carboplatin + Etoposide + Ifosfamide + Lenalidomide + Rituximab Carboplatin Etoposide Ifosfamide Lenalidomide Rituximab 0 1
Carboplatin + Etoposide + Ifosfamide + Rituximab Carboplatin Etoposide Ifosfamide Rituximab 0 4
Carboplatin + Etoposide + Ifosfamide + Rituximab + Venetoclax Carboplatin Etoposide Ifosfamide Rituximab Venetoclax 0 1
Carboplatin + Methotrexate + Rituximab Carboplatin Methotrexate Rituximab 0 1
Carfilzomib + Rituximab Carfilzomib Rituximab 0 2
Carmustine + Cytarabine + Etoposide + Filgrastim + Lenalidomide + Melphalan + Rituximab Carmustine Cytarabine Etoposide Filgrastim Lenalidomide Melphalan Rituximab 0 1
Carmustine + Cytarabine + Etoposide + Melphalan + Rituximab Carmustine Cytarabine Etoposide Melphalan Rituximab 0 1
CC-122 + Cyclophosphamide + Prednisone + Rituximab + Vincristine CC-122 Cyclophosphamide Prednisone Rituximab Vincristine 0 1
CC-90002 + Rituximab CC-90002 Rituximab 0 1
CC-99282 + Rituximab CC-99282 Rituximab 0 1
Chlorambucil + Rituximab Chlorambucil Rituximab 1 0
Cisplatin + Cytarabine + Dexamethasone + Rituximab Cisplatin Cytarabine Dexamethasone Rituximab 0 2
Cisplatin + Dexamethasone + Gemcitabine + Rituximab Cisplatin Dexamethasone Gemcitabine Rituximab 0 2
Clofarabine + Cytarabine + Dexamethasone + Idarubicin + Rituximab + Vincristine Clofarabine Cytarabine Dexamethasone Idarubicin Rituximab Vincristine 0 1
Copanlisib + Rituximab Copanlisib Rituximab 0 1
CUDC-907 + Rituximab CUDC-907 Rituximab 0 1
Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Methotrexate + Rituximab + Venetoclax + Vincristine Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Methotrexate Rituximab Venetoclax Vincristine 0 1
Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Methotrexate + Rituximab + Vincristine Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Methotrexate Rituximab Vincristine 0 1
Cyclophosphamide + Cytarabine + Dexamethasone + Methotrexate + Rituximab + Venetoclax + Vincristine Cyclophosphamide Cytarabine Dexamethasone Methotrexate Rituximab Venetoclax Vincristine 0 1
Cyclophosphamide + Cytarabine + Doxorubicin + Etoposide + Filgrastim + Ifosfamide + Leucovorin + Mesna + Methotrexate + Rituximab + Vincristine Cyclophosphamide Cytarabine Doxorubicin Etoposide Filgrastim Ifosfamide Leucovorin Mesna Methotrexate Rituximab Vincristine 0 1
Cyclophosphamide + Dexamethasone + Doxorubicin + Methotrexate + Rituximab + Venetoclax + Vincristine Cyclophosphamide Dexamethasone Doxorubicin Methotrexate Rituximab Venetoclax Vincristine 0 1
Cyclophosphamide + Dexamethasone + Doxorubicin + Rituximab + Vincristine Cyclophosphamide Dexamethasone Doxorubicin Rituximab Vincristine 0 1
Cyclophosphamide + Dexamethasone + Methotrexate + Rituximab + Venetoclax + Vincristine Cyclophosphamide Dexamethasone Methotrexate Rituximab Venetoclax Vincristine 0 1
Cyclophosphamide + Dexamethasone + Rituximab + Venetoclax + Vincristine Cyclophosphamide Dexamethasone Rituximab Venetoclax Vincristine 0 1
Cyclophosphamide + Doxorubicin + Durvalumab + Lenalidomide + Prednisone + Rituximab + Vincristine Cyclophosphamide Doxorubicin Durvalumab Lenalidomide Prednisone Rituximab Vincristine 0 1
Cyclophosphamide + Doxorubicin + Durvalumab + Prednisone + Rituximab + Vincristine Cyclophosphamide Doxorubicin Durvalumab Prednisone Rituximab Vincristine 0 1
Cyclophosphamide + Doxorubicin + Etoposide + Filgrastim + Ibrutinib + Pegfilgrastim + Prednisone + Rituximab + Vincristine Cyclophosphamide Doxorubicin Etoposide Filgrastim Ibrutinib Pegfilgrastim Prednisone Rituximab Vincristine 0 1
Cyclophosphamide + Doxorubicin + Etoposide + Fludarabine + Prednisone + Rituximab + Vincristine Cyclophosphamide Doxorubicin Etoposide Fludarabine Prednisone Rituximab Vincristine 0 1
Cyclophosphamide + Doxorubicin + Etoposide + inotuzumab ozogamicin + Prednisone + Rituximab + Vincristine Cyclophosphamide Doxorubicin Etoposide Prednisone Rituximab Vincristine inotuzumab ozogamicin 0 1
Cyclophosphamide + Doxorubicin + Etoposide + Methylprednisolone + Rituximab + Vincristine Cyclophosphamide Doxorubicin Etoposide Methylprednisolone Rituximab Vincristine 0 4
Cyclophosphamide + Doxorubicin + Etoposide + Nivolumab + Prednisone + Rituximab + Vincristine Cyclophosphamide Doxorubicin Etoposide Nivolumab Prednisone Rituximab Vincristine 0 1
Cyclophosphamide + Doxorubicin + Etoposide + Prednisone + Rituximab + Venetoclax + Vincristine Cyclophosphamide Doxorubicin Etoposide Prednisone Rituximab Venetoclax Vincristine 0 2
Cyclophosphamide + Doxorubicin + Etoposide + Prednisone + Rituximab + Vincristine Cyclophosphamide Doxorubicin Etoposide Prednisone Rituximab Vincristine 0 4
Cyclophosphamide + Doxorubicin + Lenalidomide + MOR208 + Prednisone + Rituximab + Vincristine Cyclophosphamide Doxorubicin Lenalidomide MOR208 Prednisone Rituximab Vincristine 0 1
Cyclophosphamide + Doxorubicin + LOXO-305 + Prednisone + Rituximab + Vincristine Cyclophosphamide Doxorubicin LOXO-305 Prednisone Rituximab Vincristine 0 1
Cyclophosphamide + Doxorubicin + MOR208 + Prednisone + Rituximab + Vincristine Cyclophosphamide Doxorubicin MOR208 Prednisone Rituximab Vincristine 0 1
Cyclophosphamide + Doxorubicin + Nivolumab + Prednisone + Rituximab + Vincristine Cyclophosphamide Doxorubicin Nivolumab Prednisone Rituximab Vincristine 0 1
Cyclophosphamide + Doxorubicin + Parsaclisib + Pegfilgrastim + Prednisone + Rituximab + Vincristine Cyclophosphamide Doxorubicin Parsaclisib Pegfilgrastim Prednisone Rituximab Vincristine 0 1
Cyclophosphamide + Doxorubicin + Pembrolizumab + Prednisone + Rituximab + Vincristine Cyclophosphamide Doxorubicin Pembrolizumab Prednisone Rituximab Vincristine 0 1
Cyclophosphamide + Doxorubicin + Polatuzumab vedotin-piiq + Prednisone + Rituximab Cyclophosphamide Doxorubicin Polatuzumab vedotin-piiq Prednisone Rituximab 0 1
Cyclophosphamide + Doxorubicin + Prednisone + Rituximab Cyclophosphamide Doxorubicin Prednisone Rituximab 0 1
Cyclophosphamide + Doxorubicin + Prednisone + Rituximab + RO7082859 + Vincristine Cyclophosphamide Doxorubicin Prednisone RO7082859 Rituximab Vincristine 0 1
Cyclophosphamide + Doxorubicin + Prednisone + Rituximab + TAK-659 + Vincristine Cyclophosphamide Doxorubicin Prednisone Rituximab TAK-659 Vincristine 0 1
Cyclophosphamide + Doxorubicin + Prednisone + Rituximab + Venetoclax + Vincristine Cyclophosphamide Doxorubicin Prednisone Rituximab Venetoclax Vincristine 0 1
Cyclophosphamide + Doxorubicin + Prednisone + Rituximab + Vincristine Cyclophosphamide Doxorubicin Prednisone Rituximab Vincristine 0 10
Cyclophosphamide + Fludarabine + FT596 + Rituximab Cyclophosphamide FT596 Fludarabine Rituximab 0 1
Cyclophosphamide + Fludarabine + Ibrutinib + Rituximab Cyclophosphamide Fludarabine Ibrutinib Rituximab 0 1
Cyclophosphamide + Fludarabine + KTE-C19 + Rituximab Cyclophosphamide Fludarabine KTE-C19 Rituximab 0 1
Cyclophosphamide + Fludarabine + MB-102 + Mesna + Rituximab Cyclophosphamide Fludarabine MB-102 Mesna Rituximab 0 1
Cyclophosphamide + Fludarabine + Rituximab Cyclophosphamide Fludarabine Rituximab 0 3
Cyclophosphamide + inotuzumab ozogamicin + Prednisone + Rituximab + Vincristine Cyclophosphamide Prednisone Rituximab Vincristine inotuzumab ozogamicin 1 0
Cyclophosphamide + Prednisone + Rituximab + Vincristine Cyclophosphamide Prednisone Rituximab Vincristine 0 3
Cytarabine + Dexamethasone + Etoposide + Ibrutinib + Isavuconazole + Pegylated liposomal-doxorubicin + Rituximab + Temozolomide Cytarabine Dexamethasone Etoposide Ibrutinib Isavuconazole Pegylated liposomal-doxorubicin Rituximab Temozolomide 0 1
Cytarabine + Dexamethasone + Etoposide + Isavuconazole + Pegylated liposomal-doxorubicin + Rituximab + Temozolomide Cytarabine Dexamethasone Etoposide Isavuconazole Pegylated liposomal-doxorubicin Rituximab Temozolomide 0 1
Cytarabine + Dexamethasone + Methotrexate + Ponatinib + Rituximab + Venetoclax Cytarabine Dexamethasone Methotrexate Ponatinib Rituximab Venetoclax 0 1
Cytarabine + Methotrexate + Methylprednisolone + Rituximab + Venetoclax Cytarabine Methotrexate Methylprednisolone Rituximab Venetoclax 0 1
Cytarabine + Methotrexate + Rituximab Cytarabine Methotrexate Rituximab 0 1
Cytarabine + Methotrexate + Rituximab + Venetoclax Cytarabine Methotrexate Rituximab Venetoclax 0 2
Cytarabine + Rituximab Cytarabine Rituximab 0 1
Dasatinib + Fludarabine + Rituximab Dasatinib Fludarabine Rituximab 0 1
Dexamethasone + Etoposide + Ibrutinib + Pegylated liposomal-doxorubicin + Rituximab + Temozolomide Dexamethasone Etoposide Ibrutinib Pegylated liposomal-doxorubicin Rituximab Temozolomide 0 0
Dexamethasone + Etoposide + Pegylated liposomal-doxorubicin + Rituximab + Temozolomide Dexamethasone Etoposide Pegylated liposomal-doxorubicin Rituximab Temozolomide 0 0
Dexamethasone + Filgrastim + Palifermin + Rituximab Dexamethasone Filgrastim Palifermin Rituximab 0 1
Durvalumab + Lenalidomide + Rituximab Durvalumab Lenalidomide Rituximab 0 1
Duvelisib + Rituximab Duvelisib Rituximab 0 1
Filgrastim + Methotrexate + Rituximab Filgrastim Methotrexate Rituximab 0 1
FT516 + Rituximab FT516 Rituximab 1 0
GDA-201 + Rituximab GDA-201 Rituximab 0 0
Gemcitabine + Oxaliplatin + Polatuzumab vedotin-piiq + Rituximab Gemcitabine Oxaliplatin Polatuzumab vedotin-piiq Rituximab 0 1
Gemcitabine + Oxaliplatin + Rituximab Gemcitabine Oxaliplatin Rituximab 0 3
Glucarpidase + Leucovorin + Methotrexate + Rituximab Glucarpidase Leucovorin Methotrexate Rituximab 0 1
Hu5F9-G4 + Rituximab Hu5F9-G4 Rituximab 2 1
Hyaluronidase + Rituximab Hyaluronidase Rituximab 0 0
Hyaluronidase + Rituximab + Venetoclax Hyaluronidase Rituximab Venetoclax 0 1
Ibritumomab tiuxetan + Rituximab Ibritumomab tiuxetan Rituximab 0 1
Ibrutinib + Lenalidomide + Rituximab Ibrutinib Lenalidomide Rituximab 0 8
Ibrutinib + Rituximab Ibrutinib Rituximab 0 4
Ibrutinib + Rituximab + Venetoclax Ibrutinib Rituximab Venetoclax 0 2
Idasanutlin + Obinutuzumab + Rituximab + Venetoclax Idasanutlin Obinutuzumab Rituximab Venetoclax 0 1
Idasanutlin + Rituximab + Venetoclax Idasanutlin Rituximab Venetoclax 0 1
Idelalisib + Otlertuzumab + Rituximab Idelalisib Otlertuzumab Rituximab 0 1
Idelalisib + Rituximab Idelalisib Rituximab 1 1
Idelalisib + Rituximab + Venetoclax Idelalisib Rituximab Venetoclax 0 1
IMGN529 + Rituximab IMGN529 Rituximab 0 1
INCB7839 + Rituximab INCB7839 Rituximab 0 1
Ipilimumab + Nivolumab + Rituximab Ipilimumab Nivolumab Rituximab 0 1
Ixazomib + Lenalidomide + Rituximab Ixazomib Lenalidomide Rituximab 0 1
Ixazomib + Rituximab Ixazomib Rituximab 0 3
Lenalidomide + Nivolumab + Rituximab Lenalidomide Nivolumab Rituximab 0 1
Lenalidomide + Rituximab Lenalidomide Rituximab 2 1
Lenalidomide + Rituximab + Romidepsin Lenalidomide Rituximab Romidepsin 0 1
Lenalidomide + Rituximab + Tazemetostat Lenalidomide Rituximab Tazemetostat 0 1
Lenalidomide + Rituximab + Thalidomide Lenalidomide Rituximab Thalidomide 0 1
Lenalidomide + Rituximab + Venetoclax Lenalidomide Rituximab Venetoclax 0 1
LOXO-305 + Rituximab + Venetoclax LOXO-305 Rituximab Venetoclax 0 1
ME-401 + Rituximab ME-401 Rituximab 0 1
MLN0905 + Rituximab MLN0905 Rituximab 1 0
Moxetumomab pasudotox-tdfk + Rituximab Moxetumomab pasudotox-tdfk Rituximab 0 1
MTIG7192A + Rituximab MTIG7192A Rituximab 0 1
NeoVax + Rituximab NeoVax Rituximab 0 1
Nivolumab + Poly ICLC + Rituximab Nivolumab Poly ICLC Rituximab 0 1
Obinutuzumab + Pinatuzumab Vedotin + Rituximab Obinutuzumab Pinatuzumab Vedotin Rituximab 0 1
Obinutuzumab + Polatuzumab vedotin-piiq + Rituximab Obinutuzumab Polatuzumab vedotin-piiq Rituximab 0 1
Otlertuzumab + Rituximab Otlertuzumab Rituximab 0 1
Parsaclisib + Rituximab Parsaclisib Rituximab 0 1
Pembrolizumab + Rituximab Pembrolizumab Rituximab 0 2
PF-04518600 + Rituximab + Utomilumab PF-04518600 Rituximab Utomilumab 0 1
Pinatuzumab Vedotin + Polatuzumab vedotin-piiq + Rituximab Pinatuzumab Vedotin Polatuzumab vedotin-piiq Rituximab 0 1
PQR309 + Rituximab PQR309 Rituximab 1 0
Rituximab Rituximab 2 66
Rituximab + sapacitabine Rituximab sapacitabine 0 1
Rituximab + TAK-981 Rituximab TAK-981 0 1
Rituximab + TEN-010 + Venetoclax Rituximab TEN-010 Venetoclax 0 1
Rituximab + TJ011133 Rituximab TJ011133 0 1
Rituximab + Umbralisib Rituximab Umbralisib 0 1
Rituximab + Utomilumab Rituximab Utomilumab 0 1
Rituximab + Venetoclax Rituximab Venetoclax 1 2
Rituximab + Zanubrutinib Rituximab Zanubrutinib 0 1


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