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Drug Name DS-3201b
Trade Name
Synonyms DS-3201|Valemetostat Tosylate
Drug Descriptions

DS-3201b inhibits EZH1 and EZH2, resulting in decreased H3K27 trimethylation and potentially leading to decreased tumor growth (Blood 2017 130:2073, PMID: 30658046).

DrugClasses EZH1 inhibitor 5 EZH2 inhibitor 20
CAS Registry Number 1809336-93-3
NCIT ID C168589


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + Bevacizumab + DS-3201b Atezolizumab Bevacizumab DS-3201b 0 1
Datopotamab deruxtecan + DS-3201b DS-3201b Datopotamab deruxtecan 0 1
DS-3201b DS-3201b 0 5
DS-3201b + Ipilimumab DS-3201b Ipilimumab 0 1
DS-3201b + Irinotecan DS-3201b Irinotecan 0 1
DS-3201b + Lenalidomide + Rituximab DS-3201b Lenalidomide Rituximab 0 1
DS-3201b + Pembrolizumab DS-3201b Pembrolizumab 0 1
DS-3201b + Trastuzumab deruxtecan DS-3201b Trastuzumab deruxtecan 0 2

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