Drug Detail

Drug Name Atezolizumab
Trade Name Tecentriq
Synonyms RG7446|MPDL3280A
Drug Descriptions

Tecentriq (atezolizumab) is a monoclonal antibody against PD-L1 (CD274), preventing activation of its receptor, potentially enhancing T-cell-mediated immune response to neoplasms and inhibiting T-cell inactivation (PMID: 29449897). Tecentriq (atezolizumab) is FDA approved for use in patients with advanced urothelial carcinoma, metastatic non-small cell lung cancer (NSCLC) progressed on platinum-containing therapy, in combination with bevacizumab, paclitaxel, and carboplatin for non-squamous NSCLC with no EGFR or ALK aberrations, in combination with paclitaxel protein-bound for advanced or metastatic triple-negative breast cancer expressing PD-L1, and in combination with carboplatin and etoposide for small cell lung cancer (FDA.gov).

DrugClasses Immune Checkpoint Inhibitor 99 PD-L1/PD-1 antibody 51

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Ad-E6E7 + Atezolizumab + MG1-E6E7 Ad-E6E7 Atezolizumab MG1-E6E7 0 1
Alectinib + Atezolizumab Alectinib Atezolizumab 0 1
ALX148 + Atezolizumab ALX148 Atezolizumab 0 1
Anetumab ravtansine + Atezolizumab Anetumab ravtansine Atezolizumab 0 1
Atezolizumab Atezolizumab 11 80
Atezolizumab + B-701 Atezolizumab B-701 0 1
Atezolizumab + BCG solution Atezolizumab BCG solution 0 1
Atezolizumab + Bendamustine + Obinutuzumab Atezolizumab Bendamustine Obinutuzumab 0 0
Atezolizumab + Bevacizumab Atezolizumab Bevacizumab 0 10
Atezolizumab + Bevacizumab + Capecitabine Atezolizumab Bevacizumab Capecitabine 0 4
Atezolizumab + Bevacizumab + Carboplatin Atezolizumab Bevacizumab Carboplatin 0 1
Atezolizumab + Bevacizumab + Carboplatin + Paclitaxel Atezolizumab Bevacizumab Carboplatin Paclitaxel 1 2
Atezolizumab + Bevacizumab + Carboplatin + Pemetrexed Atezolizumab Bevacizumab Carboplatin Pemetrexed 0 1
Atezolizumab + Bevacizumab + Cisplatin Atezolizumab Bevacizumab Cisplatin 0 1
Atezolizumab + Bevacizumab + Cobimetinib Atezolizumab Bevacizumab Cobimetinib 0 2
Atezolizumab + Bevacizumab + Entinostat Atezolizumab Bevacizumab Entinostat 0 1
Atezolizumab + Bevacizumab + Exemestane Atezolizumab Bevacizumab Exemestane 0 1
Atezolizumab + Bevacizumab + Fluorouracil + Leucovorin + Oxaliplatin Atezolizumab Bevacizumab Fluorouracil Leucovorin Oxaliplatin 0 2
Atezolizumab + Bevacizumab + Fulvestrant Atezolizumab Bevacizumab Fulvestrant 0 1
Atezolizumab + Bevacizumab + Obinutuzumab + RO6874281 Atezolizumab Bevacizumab Obinutuzumab RO6874281 0 1
Atezolizumab + Bevacizumab + Peg-interferon alfa-2a Atezolizumab Bevacizumab Peg-interferon alfa-2a 0 1
Atezolizumab + Bevacizumab + Pegylated liposomal-doxorubicin Atezolizumab Bevacizumab Pegylated liposomal-doxorubicin 0 1
Atezolizumab + Bevacizumab + PGG beta-glucan Atezolizumab Bevacizumab PGG beta-glucan 0 1
Atezolizumab + Bevacizumab + Rucaparib Atezolizumab Bevacizumab Rucaparib 0 1
Atezolizumab + Bevacizumab + Tamoxifen Atezolizumab Bevacizumab Tamoxifen 0 1
Atezolizumab + BKT140 Atezolizumab BKT140 0 3
Atezolizumab + BTCT4465A Atezolizumab BTCT4465A 0 1
Atezolizumab + Cabozantinib Atezolizumab Cabozantinib 0 3
Atezolizumab + Capecitabine Atezolizumab Capecitabine 0 1
Atezolizumab + Capecitabine + Carboplatin + Gemcitabine Atezolizumab Capecitabine Carboplatin Gemcitabine 0 1
Atezolizumab + Carboplatin Atezolizumab Carboplatin 0 2
Atezolizumab + Carboplatin + Cisplatin + Nab-paclitaxel + Pemetrexed Atezolizumab Carboplatin Cisplatin Nab-paclitaxel Pemetrexed 0 1
Atezolizumab + Carboplatin + Etoposide Atezolizumab Carboplatin Etoposide 2 4
Atezolizumab + Carboplatin + Etoposide + Trilaciclib Atezolizumab Carboplatin Etoposide Trilaciclib 0 1
Atezolizumab + Carboplatin + Gemcitabine Atezolizumab Carboplatin Gemcitabine 0 4
Atezolizumab + Carboplatin + Nab-paclitaxel Atezolizumab Carboplatin Nab-paclitaxel 0 1
Atezolizumab + Carboplatin + Paclitaxel Atezolizumab Carboplatin Paclitaxel 0 4
Atezolizumab + Carboplatin + Pemetrexed Atezolizumab Carboplatin Pemetrexed 0 2
Atezolizumab + Cisplatin Atezolizumab Cisplatin 0 2
Atezolizumab + Cisplatin + Etoposide Atezolizumab Cisplatin Etoposide 0 1
Atezolizumab + Cisplatin + Fluorouracil Atezolizumab Cisplatin Fluorouracil 0 1
Atezolizumab + Cisplatin + Gemcitabine Atezolizumab Cisplatin Gemcitabine 0 2
Atezolizumab + Cisplatin + Gemcitabine + PEGPH20 Atezolizumab Cisplatin Gemcitabine PEGPH20 0 1
Atezolizumab + Cisplatin + Mitomycin C Atezolizumab Cisplatin Mitomycin C 0 1
Atezolizumab + Cisplatin + Pemetrexed Atezolizumab Cisplatin Pemetrexed 0 1
Atezolizumab + Cobimetinib Atezolizumab Cobimetinib 2 15
Atezolizumab + Cobimetinib + Eribulin Atezolizumab Cobimetinib Eribulin 0 1
Atezolizumab + Cobimetinib + Fluorouracil + Leucovorin + Oxaliplatin Atezolizumab Cobimetinib Fluorouracil Leucovorin Oxaliplatin 0 1
Atezolizumab + Cobimetinib + Niraparib Atezolizumab Cobimetinib Niraparib 0 1
Atezolizumab + Cobimetinib + Vemurafenib Atezolizumab Cobimetinib Vemurafenib 1 3
Atezolizumab + CPI-444 Atezolizumab CPI-444 2 2
Atezolizumab + CV301 Atezolizumab CV301 0 1
Atezolizumab + Cyclophosphamide + Doxorubicin Atezolizumab Cyclophosphamide Doxorubicin 0 1
Atezolizumab + Cyclophosphamide + Epirubicin + Paclitaxel Atezolizumab Cyclophosphamide Epirubicin Paclitaxel 0 1
Atezolizumab + CYT107 Atezolizumab CYT107 0 1
Atezolizumab + Daratumumab Atezolizumab Daratumumab 0 1
Atezolizumab + DEC-205-NY-ESO-1 fusion protein vaccine Atezolizumab DEC-205-NY-ESO-1 fusion protein vaccine 0 1
Atezolizumab + DEC-205-NY-ESO-1 fusion protein vaccine + Guadecitabine Atezolizumab DEC-205-NY-ESO-1 fusion protein vaccine Guadecitabine 0 1
Atezolizumab + Docetaxel Atezolizumab Docetaxel 0 1
Atezolizumab + DSP-7888 Atezolizumab DSP-7888 0 1
Atezolizumab + Emactuzumab Atezolizumab Emactuzumab 0 3
Atezolizumab + Enfortumab vedotin Atezolizumab Enfortumab vedotin 0 1
Atezolizumab + Enfortumab vedotin + Pembrolizumab Atezolizumab Enfortumab vedotin Pembrolizumab 0 1
Atezolizumab + Entinostat Atezolizumab Entinostat 0 2
Atezolizumab + Enzalutamide Atezolizumab Enzalutamide 0 2
Atezolizumab + Epacadostat Atezolizumab Epacadostat 0 1
Atezolizumab + Eribulin Atezolizumab Eribulin 0 1
Atezolizumab + Erlotinib Atezolizumab Erlotinib 0 1
Atezolizumab + FANG vaccine Atezolizumab FANG vaccine 0 1
Atezolizumab + Fluorouracil Atezolizumab Fluorouracil 0 0
Atezolizumab + Fluorouracil + Leucovorin + Oxaliplatin Atezolizumab Fluorouracil Leucovorin Oxaliplatin 0 2
Atezolizumab + Fluorouracil + Mitomycin C Atezolizumab Fluorouracil Mitomycin C 0 1
Atezolizumab + Fluorouracil + Oxaliplatin Atezolizumab Fluorouracil Oxaliplatin 0 1
Atezolizumab + FT500 Atezolizumab FT500 0 1
Atezolizumab + Fulvestrant Atezolizumab Fulvestrant 0 1
Atezolizumab + Fulvestrant + Ipatasertib Atezolizumab Fulvestrant Ipatasertib 0 1
Atezolizumab + GDC-0919 Atezolizumab GDC-0919 1 0
Atezolizumab + Gemcitabine Atezolizumab Gemcitabine 0 0
Atezolizumab + Gemcitabine + Mitomycin C Atezolizumab Gemcitabine Mitomycin C 0 1
Atezolizumab + Gemcitabine + Nab-paclitaxel Atezolizumab Gemcitabine Nab-paclitaxel 0 1
Atezolizumab + Gemcitabine + Oxaliplatin + Rituximab Atezolizumab Gemcitabine Oxaliplatin Rituximab 0 1
Atezolizumab + Gilteritinib Atezolizumab Gilteritinib 0 1
Atezolizumab + Guadecitabine Atezolizumab Guadecitabine 0 4
Atezolizumab + Hu5F9-G4 Atezolizumab Hu5F9-G4 0 2
Atezolizumab + Idasanutlin Atezolizumab Idasanutlin 0 1
Atezolizumab + IMC-C103C Atezolizumab IMC-C103C 0 1
Atezolizumab + INO-5401 + INO-9012 Atezolizumab INO-5401 INO-9012 0 1
Atezolizumab + Interferon alpha-2b Atezolizumab Interferon alpha-2b 0 1
Atezolizumab + Ipatasertib Atezolizumab Ipatasertib 0 2
Atezolizumab + Ipatasertib + Nab-paclitaxel Atezolizumab Ipatasertib Nab-paclitaxel 0 1
Atezolizumab + Ipatasertib + Paclitaxel Atezolizumab Ipatasertib Paclitaxel 0 1
Atezolizumab + Ipilimumab Atezolizumab Ipilimumab 0 1
Atezolizumab + Isatuximab Atezolizumab Isatuximab 0 3
Atezolizumab + KTE-C19 Atezolizumab KTE-C19 0 1
Atezolizumab + KY1044 Atezolizumab KY1044 0 1
Atezolizumab + Lenalidomide + Obinutuzumab Atezolizumab Lenalidomide Obinutuzumab 0 1
Atezolizumab + Linagliptin Atezolizumab Linagliptin 0 2
Atezolizumab + MOXR0916 Atezolizumab MOXR0916 0 1
Atezolizumab + MTIG7192A Atezolizumab MTIG7192A 0 2
Atezolizumab + MV-NIS Atezolizumab MV-NIS 0 1
Atezolizumab + Nab-paclitaxel Atezolizumab Nab-paclitaxel 0 2
Atezolizumab + Niraparib Atezolizumab Niraparib 0 1
Atezolizumab + Obinutuzumab Atezolizumab Obinutuzumab 0 4
Atezolizumab + Obinutuzumab + Polatuzumab Vedotin Atezolizumab Obinutuzumab Polatuzumab vedotin-piiq 0 1
Atezolizumab + Obinutuzumab + RO6874281 Atezolizumab Obinutuzumab RO6874281 0 1
Atezolizumab + Obinutuzumab + RO6958688 Atezolizumab Obinutuzumab RO6958688 0 1
Atezolizumab + Olaparib Atezolizumab Olaparib 0 1
Atezolizumab + Paclitaxel Atezolizumab Paclitaxel 0 2
Atezolizumab + Paclitaxel + Pertuzumab + Trastuzumab Atezolizumab Paclitaxel Pertuzumab Trastuzumab 0 2
Atezolizumab + Peg-interferon alfa-2a Atezolizumab Peg-interferon alfa-2a 0 1
Atezolizumab + PEGPH20 Atezolizumab PEGPH20 0 3
Atezolizumab + Pegylated liposomal-doxorubicin Atezolizumab Pegylated liposomal-doxorubicin 0 1
Atezolizumab + Pertuzumab + Trastuzumab Atezolizumab Pertuzumab Trastuzumab 0 2
Atezolizumab + PGV 001 Atezolizumab PGV 001 0 1
Atezolizumab + PRS-343 Atezolizumab PRS-343 0 1
Atezolizumab + PVSRIPO Atezolizumab PVSRIPO 0 1
Atezolizumab + QbG10 Atezolizumab QbG10 0 1
Atezolizumab + Radium Ra 223 dichloride Atezolizumab Radium Ra 223 dichloride 0 2
Atezolizumab + Ramucirumab Atezolizumab Ramucirumab 0 1
Atezolizumab + Rituximab Atezolizumab Rituximab 0 1
Atezolizumab + RO6874281 Atezolizumab RO6874281 0 1
Atezolizumab + RO6958688 Atezolizumab RO6958688 0 2
Atezolizumab + RO7198457 Atezolizumab RO7198457 0 1
Atezolizumab + Rociletinib Atezolizumab Rociletinib 0 1
Atezolizumab + Rogaratinib Atezolizumab Rogaratinib 0 1
Atezolizumab + Sapitinib Atezolizumab Sapitinib 0 0
Atezolizumab + SGN-LIV1A Atezolizumab SGN-LIV1A 0 1
Atezolizumab + Sipuleucel-T Atezolizumab Sipuleucel-T 0 1
Atezolizumab + Talimogene laherparepvec Atezolizumab Talimogene laherparepvec 0 1
Atezolizumab + Temozolomide Atezolizumab Temozolomide 0 1
Atezolizumab + TEN-010 Atezolizumab TEN-010 0 1
Atezolizumab + Tesetaxel Atezolizumab Tesetaxel 0 1
Atezolizumab + TJ004309 Atezolizumab TJ004309 0 1
Atezolizumab + Tocilizumab Atezolizumab Tocilizumab 0 1
Atezolizumab + Trastuzumab Atezolizumab Trastuzumab 0 2
Atezolizumab + Varlilumab Atezolizumab Varlilumab 0 1
Atezolizumab + Veliparib Atezolizumab Veliparib 0 0
Atezolizumab + Vemurafenib Atezolizumab Vemurafenib 0 1


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