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Drug Name Tarlatamab
Trade Name Imdelltra
Synonyms AMG 757|AMG757|AMG-757|tarlatamab-dlle
Drug Descriptions

Imdelltra (tarlatamab) is a bispecific antibody that targets CD3 on T-cells and delta-like protein 3 (DLL3) expressed by tumor cells, which may lead to cytotoxic killing of Dll3-expressing tumor cells (PMID: 31215500). Imdelltra (tarlatamab) is FDA-approved for use in patients with extensive stage small cell lung cancer who progressed on or after platinum-based chemotherapy (FDA.gov).

DrugClasses CD3 Antibody 96
CAS Registry Number NA
NCIT ID C147027

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Therapy Name Drugs Efficacy Evidence Clinical Trials
AMG 404 + Tarlatamab AMG 404 Tarlatamab 0 1
Atezolizumab + Carboplatin + Etoposide + Tarlatamab Atezolizumab Carboplatin Etoposide Tarlatamab 0 1
Atezolizumab + Tarlatamab Atezolizumab Tarlatamab 0 1
Durvalumab + Tarlatamab Durvalumab Tarlatamab 0 1
Tarlatamab Tarlatamab 0 5


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