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Therapy Name | AMG 404 + Tarlatamab |
Synonyms | |
Therapy Description | |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
AMG 404 | AMG404|AMG-404|zeluvalimab | Immune Checkpoint Inhibitor 147 PD-L1/PD-1 antibody 117 | AMG 404 is a monoclonal antibody that binds to and inhibits PD-1 signaling, potentially resulting in restoration of anti-tumor immune response (NCI Drug Dictionary). | |
Tarlatamab | AMG 757|AMG757|AMG-757 | CD3 Antibody 90 | Tarlatamab (AMG 757) is a bispecific antibody that targets CD3 on T-cells and delta-like protein 3 (DLL3) expressed by tumor cells (PMID: 31215500). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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NCT04885998 | Phase I | AMG 404 + Tarlatamab | AMG 757 and AMG 404 in Subjects With Small Cell Lung Cancer (SCLC) | Active, not recruiting | USA | BEL | AUT | 3 |