Therapy Detail

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Therapy Name AMG 757
Synonyms
Therapy Description

AMG 757 is a bispecific antibody that targets CD3 on T-cells and delta-like protein 3 (DLL3) expressed by tumor cells (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
AMG 757 AMG757|AMG-757 CD3 Antibody 56 AMG 757 is a bispecific antibody that targets CD3 on T-cells and delta-like protein 3 (DLL3) expressed by tumor cells (PMID: 31215500).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04702737 Phase I AMG 757 A Study of AMG 757 in Participants With Neuroendocrine Prostate Cancer Recruiting USA | FRA | ESP | BEL | AUT 4
NCT05060016 Phase II AMG 757 A Phase 2 Study of Tarlatamab in Patients With Small Cell Lung Cancer (SCLC) Recruiting USA | ITA | FRA | ESP | DEU | BEL | AUT 9
NCT03319940 Phase I AMG 757 Study Evaluating Safety, Tolerability and PK of AMG 757 in Adults With Small Cell Lung Cancer Recruiting USA | FRA | ESP | DEU | AUT 6


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