Therapy Detail

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Therapy Name Lurbinectedin
Synonyms
Therapy Description

Zepzelca (lurbinectedin) is an alkaloid analogue that binds to the minor groove of DNA, resulting in delayed cell cycle progression and cell death (PMID: 20977459). Zepzelca (lurbinectedin) is an FDA-approved chemotherapy agent (FDA.gov).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Lurbinectedin Zepzelca PM01183 Chemotherapy - Alkylating 18 Zepzelca (lurbinectedin) is an alkaloid analogue that binds to the minor groove of DNA, resulting in delayed cell cycle progression and cell death (PMID: 20977459). Zepzelca (lurbinectedin) is an FDA-approved chemotherapy agent (FDA.gov).

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02454972 Phase II Lurbinectedin Clinical Trial of Lurbinectedin (PM01183) in Selected Advanced Solid Tumors Completed USA | ITA | GBR | FRA | ESP | DEU | BEL 2
NCT01405391 Phase I Lurbinectedin Study of PM01183 in Non-Colorectal Cancer Patients as a Days 1 and 8 Intravenous Short Infusion Every 3 Weeks Completed USA 0
NCT05734066 Phase Ib/II Lurbinectedin Study of Lurbinectedin Monotherapy in Pediatric and Young Adult Participants With Relapsed/Refractory Ewing Sarcoma (EMERGE 101) Recruiting USA | CAN 0
NCT06217536 Phase Ib/II Lurbinectedin Neoadjuvant Lurbinectedin and Preoperative Radiation for Treating Soft Tissue Sarcomas Not yet recruiting USA 0
NCT06228066 Phase II Avelumab + Lurbinectedin Lurbinectedin Lurbinectedin With or Without Avelumab in Small Cell Carcinoma of the Bladder (LASER) Recruiting USA 0
NCT06203210 Phase III Ifinatamab deruxtecan Amrubicin Lurbinectedin Topotecan A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung Cancer (IDeate-Lung02) Not yet recruiting USA | NLD | ITA | GBR | FRA | ESP | DEU | CAN | BEL | AUS 11
NCT05918640 Phase Ib/II Lurbinectedin Lurbinectedin in FET-Fused Tumors (LiFFT) Recruiting USA 0
NCT05740566 Phase III Lurbinectedin Topotecan Amrubicin Tarlatamab Study Comparing Tarlatamab With Standard of Care Chemotherapy in Relapsed Small Cell Lung Cancer (DeLLphi-304) Recruiting USA | NLD | ITA | GBR | FRA | ESP | DEU | CAN | BEL | AUT | AUS 20
NCT01525589 Phase II Lurbinectedin A Phase II Clinical Trial of PM01183 in BRCA 1/2-Associated or Unselected Metastatic Breast Cancer Completed USA | ESP 0


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