Drug Detail


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Drug Name Lurbinectedin
Trade Name Zepzelca
Synonyms PM01183
Drug Descriptions

Zepzelca (lurbinectedin) is an alkaloid analogue that binds to the minor groove of DNA, resulting in delayed cell cycle progression and cell death (PMID: 20977459). Zepzelca (lurbinectedin) is an FDA-approved chemotherapy agent (FDA.gov).

DrugClasses Chemotherapy - Alkylating 18
CAS Registry Number 497871-47-3
NCIT ID C82382


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + Carboplatin + Etoposide + Lurbinectedin Atezolizumab Carboplatin Etoposide Lurbinectedin 0 1
Atezolizumab + Lurbinectedin Atezolizumab Lurbinectedin 0 1
Avelumab + Lurbinectedin Avelumab Lurbinectedin 0 2
Berzosertib + Lurbinectedin Berzosertib Lurbinectedin 0 1
Bevacizumab + Lurbinectedin + Paclitaxel Bevacizumab Lurbinectedin Paclitaxel 0 2
Doxorubicin + Lurbinectedin Doxorubicin Lurbinectedin 0 1
Durvalumab + Lurbinectedin Durvalumab Lurbinectedin 0 1
Ipilimumab + Lurbinectedin + Nivolumab Ipilimumab Lurbinectedin Nivolumab 0 1
Irinotecan + Lurbinectedin Irinotecan Lurbinectedin 0 1
Lurbinectedin Lurbinectedin 0 9
Lurbinectedin + Paclitaxel Lurbinectedin Paclitaxel 0 1
Lurbinectedin + Pembrolizumab Lurbinectedin Pembrolizumab 0 1
Lurbinectedin + Trilaciclib Lurbinectedin Trilaciclib 0 1

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