Drug Detail


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Drug Name Trilaciclib
Trade Name
Synonyms G1T28
Drug Descriptions

Trilaciclib (G1T28) is a small molecule that inhibits CDK4/6, resulting in reversible cell-cycle arrest, and potentially reduces myelosuppression induced by chemotherapeutics (PMID: 26826116, PMID: 31575503).

DrugClasses CDK4/6 Inhibitor 13
CAS Registry Number 1374743-00-6
NCIT ID C123281


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + Carboplatin + Etoposide + Trilaciclib Atezolizumab Carboplatin Etoposide Trilaciclib 0 1
Avelumab + Trilaciclib Avelumab Trilaciclib 0 1
Carboplatin + Gemcitabine + Pembrolizumab + Trilaciclib Carboplatin Gemcitabine Pembrolizumab Trilaciclib 0 1
Carboplatin + Gemcitabine + Trilaciclib Carboplatin Gemcitabine Trilaciclib 0 3
Carboplatin + Paclitaxel + Trilaciclib Carboplatin Paclitaxel Trilaciclib 0 1
Cisplatin + Gemcitabine + Trilaciclib Cisplatin Gemcitabine Trilaciclib 0 1
Cyclophosphamide + Doxorubicin + Pembrolizumab + Trilaciclib Cyclophosphamide Doxorubicin Pembrolizumab Trilaciclib 0 1
Cyclophosphamide + Doxorubicin + Trilaciclib Cyclophosphamide Doxorubicin Trilaciclib 0 0
Docetaxel + Trilaciclib Docetaxel Trilaciclib 0 1
Lurbinectedin + Trilaciclib Lurbinectedin Trilaciclib 0 1
Pertuzumab + Trastuzumab + Trilaciclib Pertuzumab Trastuzumab Trilaciclib 0 1
Sacituzumab govitecan-hziy + Trilaciclib Sacituzumab govitecan-hziy Trilaciclib 0 1
Topotecan + Trilaciclib Topotecan Trilaciclib 1 1
Trilaciclib Trilaciclib 1 5

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