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Drug Name Sacituzumab govitecan-hziy
Trade Name Trodelvy
Synonyms IMMU-132|Sactizumab|Sacituzumab govitecan
Drug Descriptions

Trodelvy (sacituzumab govitecan-hziy) is an antibody-drug conjugate composed of a monoclonal anti-TROP2 antibody linked to the active metabolite of irinotecan (SN-38), which binds to TROP2 positive cancer cells and induces DNA breakage and apoptosis (PMID: 26541586). Trodelvy (sacituzumab govitecan-hziy) is FDA approved for use in patients with metastatic triple-negative breast cancer who received two or more prior therapies, in patients with hormone receptor-positive, ERBB2 (HER2)-negative breast cancer who have received endocrine-based therapy and at least two additional systemic therapies, and in patients with locally advanced or metastatic urothelial cancer who received a platinum-containing chemotherapy and a PD-1 or PD-L1 inhibitor (FDA.gov).

DrugClasses TROP2 Antibody 8
CAS Registry Number 1491917-83-9
NCIT ID C102783

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Therapy Name Drugs Efficacy Evidence Clinical Trials
AB154 + Sacituzumab govitecan-hziy + Zimberelimab AB154 Sacituzumab govitecan-hziy Zimberelimab 0 2
Alpelisib + Sacituzumab govitecan-hziy Alpelisib Sacituzumab govitecan-hziy 0 1
Atezolizumab + Sacituzumab govitecan-hziy Atezolizumab Sacituzumab govitecan-hziy 0 1
Avelumab + Sacituzumab govitecan-hziy Avelumab Sacituzumab govitecan-hziy 0 1
Berzosertib + Sacituzumab govitecan-hziy Berzosertib Sacituzumab govitecan-hziy 0 1
Bevacizumab + Sacituzumab govitecan-hziy Bevacizumab Sacituzumab govitecan-hziy 0 1
Carboplatin + Pembrolizumab + Sacituzumab govitecan-hziy Carboplatin Pembrolizumab Sacituzumab govitecan-hziy 0 1
Cisplatin + Pembrolizumab + Sacituzumab govitecan-hziy Cisplatin Pembrolizumab Sacituzumab govitecan-hziy 0 1
Cisplatin + Sacituzumab govitecan-hziy Cisplatin Sacituzumab govitecan-hziy 0 1
Cyclophosphamide + Nogapendekin alfa inbakicept + PD-L1.t-haNK cells + Sacituzumab govitecan-hziy Cyclophosphamide Nogapendekin alfa inbakicept PD-L1.t-haNK cells Sacituzumab govitecan-hziy 0 1
Enfortumab vedotin-ejfv + Sacituzumab govitecan-hziy Enfortumab vedotin-ejfv Sacituzumab govitecan-hziy 0 1
Etrumadenant + Sacituzumab govitecan-hziy + Zimberelimab Etrumadenant Sacituzumab govitecan-hziy Zimberelimab 0 1
GS-0201 + Sacituzumab govitecan-hziy GS-0201 Sacituzumab govitecan-hziy 0 1
GS-9716 + Sacituzumab govitecan-hziy GS-9716 Sacituzumab govitecan-hziy 0 1
Hu5F9-G4 + Sacituzumab govitecan-hziy Hu5F9-G4 Sacituzumab govitecan-hziy 0 1
Ipilimumab + Nivolumab + Sacituzumab govitecan-hziy Ipilimumab Nivolumab Sacituzumab govitecan-hziy 0 1
Loperamide + Sacituzumab govitecan-hziy + Sargramostim Loperamide Sacituzumab govitecan-hziy Sargramostim 0 1
Pembrolizumab + Sacituzumab govitecan-hziy Pembrolizumab Sacituzumab govitecan-hziy 0 9
Rucaparib + Sacituzumab govitecan-hziy Rucaparib Sacituzumab govitecan-hziy 0 1
Sacituzumab govitecan-hziy Sacituzumab govitecan-hziy 0 36
Sacituzumab govitecan-hziy + Talazoparib Sacituzumab govitecan-hziy Talazoparib 0 1
Sacituzumab govitecan-hziy + Trastuzumab Sacituzumab govitecan-hziy Trastuzumab 0 1
Sacituzumab govitecan-hziy + trastuzumab and hyaluronidase-oysk injection Sacituzumab govitecan-hziy trastuzumab and hyaluronidase-oysk injection 0 1
Sacituzumab govitecan-hziy + Trilaciclib Sacituzumab govitecan-hziy Trilaciclib 0 1
Sacituzumab govitecan-hziy + Zimberelimab Sacituzumab govitecan-hziy Zimberelimab 0 1


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