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Drug Name Sacituzumab govitecan-hziy
Trade Name Trodelvy
Synonyms IMMU-132|Sactizumab
Drug Descriptions

Trodelvy (sacituzumab govitecan-hziy) is an antibody-drug conjugate composed of a monoclonal anti-TROP2 antibody linked to the active metabolite of irinotecan (SN-38), which binds to TROP2 positive cancer cells and induces DNA breakage and apoptosis (PMID: 26541586). Trodelvy (sacituzumab govitecan-hziy) is FDA approved for use in patients with metastatic triple-negative breast cancer who received two or more priotr therapies (FDA.gov).

DrugClasses

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Pembrolizumab + Sacituzumab govitecan-hziy Pembrolizumab Sacituzumab govitecan-hziy 0 2
Rucaparib + Sacituzumab govitecan-hziy Rucaparib Sacituzumab govitecan-hziy 0 1
Sacituzumab govitecan-hziy Sacituzumab govitecan-hziy 4 10
Sacituzumab govitecan-hziy + Talazoparib Sacituzumab govitecan-hziy Talazoparib 0 1


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