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Drug Name Berzosertib
Trade Name
Synonyms VX-970|VE-822|M6620
Drug Descriptions

Berzosertib (VX-970) is a small molecule inhibitor of ATR, which may enhance the sensitivity of chemotherapeutic agents resulting in antitumor activity (PMID: 25269479, PMID: 32109490).

DrugClasses ATR Inhibitor 16
CAS Registry Number 1232416-25-9
NCIT ID C116355

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Adavosertib + Berzosertib Adavosertib Berzosertib 0 0
Avelumab + Berzosertib Avelumab Berzosertib 0 1
Avelumab + Berzosertib + Carboplatin Avelumab Berzosertib Carboplatin 0 1
Avelumab + Berzosertib + Carboplatin + Gemcitabine Avelumab Berzosertib Carboplatin Gemcitabine 0 1
AZD7762 + Berzosertib AZD7762 Berzosertib 0 0
Berzosertib Berzosertib 7 6
Berzosertib + Camptothecin Berzosertib Camptothecin 0 0
Berzosertib + Carboplatin Berzosertib Carboplatin 0 1
Berzosertib + Carboplatin + Cisplatin Berzosertib Carboplatin Cisplatin 0 1
Berzosertib + Carboplatin + Gemcitabine Berzosertib Carboplatin Gemcitabine 0 0
Berzosertib + Cisplatin Berzosertib Cisplatin 1 2
Berzosertib + Cisplatin + Etoposide Berzosertib Cisplatin Etoposide 0 1
Berzosertib + Cisplatin + Gemcitabine Berzosertib Cisplatin Gemcitabine 0 2
Berzosertib + Cisplatin + Veliparib Berzosertib Cisplatin Veliparib 0 1
Berzosertib + Gemcitabine Berzosertib Gemcitabine 0 2
Berzosertib + Gemcitabine + Radiotherapy Berzosertib Gemcitabine Radiotherapy 0 0
Berzosertib + Irinotecan Berzosertib Irinotecan 2 3
Berzosertib + Lurbinectedin Berzosertib Lurbinectedin 0 1
Berzosertib + Olaparib Berzosertib Olaparib 0 0
Berzosertib + Radiotherapy Berzosertib Radiotherapy 0 0
Berzosertib + Rucaparib Berzosertib Rucaparib 0 0
Berzosertib + Sacituzumab govitecan-hziy Berzosertib Sacituzumab govitecan-hziy 0 1
Berzosertib + Sapacitabine Berzosertib Sapacitabine 0 0
Berzosertib + SAR-020106 Berzosertib SAR-020106 0 0
Berzosertib + Talazoparib Berzosertib Talazoparib 0 0
Berzosertib + Topotecan Berzosertib Topotecan 0 2


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