Drug Detail

Drug Name Olaparib
Trade Name Lynparza
Synonyms AZD2281|KU-0059436
Drug Descriptions

Lynparza (olaparib) binds to and inhibits PARP, resulting in inhibition of DNA repair and lethality in homologous-recombination deficient cells, and may be a sensitizing agent for chemotherapy and radiotherapy (PMID: 25028150, PMID: 24225019). Lynparza (olaparib) is FDA approved for use in patients with deleterious or suspected deleterious germline BRCA-mutated advanced ovarian cancer, germline BRCA-mutated and ERBB2 (HER2)-negative breast cancer, and advanced epithelial ovarian, fallopian tube or primary peritoneal cancer with deleterious or suspected deleterious germline or somatic BRCA mutations (FDA.gov).

DrugClasses PARP Inhibitor (Pan) 17

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + Olaparib Abiraterone Olaparib 1 1
Abiraterone + Olaparib + Prednisone Abiraterone Olaparib Prednisone 0 1
Adavosertib + Olaparib Adavosertib Olaparib 1 3
AGI-5198 + Olaparib AGI-5198 Olaparib 1 0
Alpelisib + Olaparib Alpelisib Olaparib 1 1
Atezolizumab + Olaparib Atezolizumab Olaparib 0 1
AZD6482 + Olaparib AZD6482 Olaparib 1 0
AZD6738 + Olaparib AZD6738 Olaparib 1 6
Bendamustine + Olaparib Bendamustine Olaparib 1 0
Bevacizumab + Carboplatin + Olaparib + Paclitaxel + Pembrolizumab Bevacizumab Carboplatin Olaparib Paclitaxel Pembrolizumab 0 1
Bevacizumab + Carboplatin + Olaparib + Pembrolizumab Bevacizumab Carboplatin Olaparib Pembrolizumab 0 0
Bevacizumab + Cisplatin + Olaparib + Paclitaxel Bevacizumab Cisplatin Olaparib Paclitaxel 0 1
Bevacizumab + Durvalumab + Olaparib Bevacizumab Durvalumab Olaparib 0 2
Bevacizumab + Olaparib + Paclitaxel + Pembrolizumab Bevacizumab Olaparib Paclitaxel Pembrolizumab 0 0
BGB-324 + Olaparib BGB-324 Olaparib 0 0
BGJ398 + Olaparib BGJ398 Olaparib 0 0
BPTES + Olaparib BPTES Olaparib 1 0
Buparlisib + Olaparib Buparlisib Olaparib 1 1
Camptothecin + Olaparib Camptothecin Olaparib 1 0
Capivasertib + Olaparib Capivasertib Olaparib 3 2
Carboplatin + Olaparib Carboplatin Olaparib 0 0
Carboplatin + Olaparib + Paclitaxel + Pembrolizumab Carboplatin Olaparib Paclitaxel Pembrolizumab 0 1
Carboplatin + Olaparib + Pembrolizumab Carboplatin Olaparib Pembrolizumab 0 0
CB-839 + Olaparib CB-839 Olaparib 1 0
CCT241533 + Olaparib CCT241533 Olaparib 1 0
Cediranib + Durvalumab + Olaparib Cediranib Durvalumab Olaparib 1 0
Cediranib + Olaparib Cediranib Olaparib 1 11
Cetuximab + Olaparib Cetuximab Olaparib 0 1
Cisplatin + Olaparib Cisplatin Olaparib 1 0
CRLX101 + Olaparib CRLX101 Olaparib 0 1
CYT01B + Olaparib CYT01B Olaparib 1 0
Dinaciclib + Olaparib Dinaciclib Olaparib 0 0
Durvalumab + Olaparib Durvalumab Olaparib 2 13
Durvalumab + Olaparib + Tremelimumab Durvalumab Olaparib Tremelimumab 0 1
Entinostat + Olaparib Entinostat Olaparib 0 1
Everolimus + Olaparib Everolimus Olaparib 0 0
Fludarabine + Olaparib Fludarabine Olaparib 1 0
Fulvestrant + Olaparib + Palbociclib Fulvestrant Olaparib Palbociclib 0 1
Irinotecan + Olaparib Irinotecan Olaparib 0 0
KU-0063794 + Olaparib KU-0063794 Olaparib 0 0
Olaparib Olaparib 34 61
Olaparib + Onalespib Olaparib Onalespib 0 1
Olaparib + Paclitaxel Olaparib Paclitaxel 4 0
Olaparib + Paclitaxel + Pembrolizumab Olaparib Paclitaxel Pembrolizumab 0 0
Olaparib + Pembrolizumab Olaparib Pembrolizumab 0 2
Olaparib + Prexasertib Olaparib Prexasertib 0 1
Olaparib + Ramucirumab Olaparib Ramucirumab 0 1
Olaparib + sapacitabine Olaparib sapacitabine 0 1
Olaparib + Selumetinib Olaparib Selumetinib 0 1
Olaparib + SN-38 Olaparib SN-38 1 0
Olaparib + SN-38 + Temozolomide Olaparib SN-38 Temozolomide 1 0
Olaparib + Temozolomide Olaparib Temozolomide 3 1
Olaparib + Testosterone Enanthate Olaparib Testosterone Enanthate 0 1
Olaparib + TP-0903 Olaparib TP-0903 0 0
Olaparib + Trabectedin Olaparib Trabectedin 1 0
Olaparib + Trametinib Olaparib Trametinib 0 0
Olaparib + Tremelimumab Olaparib Tremelimumab 0 1
Olaparib + Valproic acid Olaparib Valproic acid 1 0
Olaparib + VE-821 Olaparib VE-821 0 0
Olaparib + Vistusertib Olaparib Vistusertib 0 2
Olaparib + Vorinostat Olaparib Vorinostat 0 1
Olaparib + YU238259 Olaparib YU238259 0 0


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