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Drug Name Olaparib
Trade Name Lynparza
Synonyms AZD2281|KU-0059436
Drug Descriptions

Lynparza (olaparib) binds to and inhibits PARP, resulting in inhibition of DNA repair and lethality in homologous-recombination deficient cells, and may be a sensitizing agent for chemotherapy and radiotherapy (PMID: 25028150, PMID: 24225019). Lynparza (olaparib) is FDA approved for treatment of ERBB2 (HER2)-negative breast cancer with deleterious or suspected deleterious germline BRCA mutations, ovarian cancer with deleterious or suspected deleterious germline BRCA mutations and received 3 or more prior therapies, metastatic pancreatic adenocarcinoma with deleterious or suspected deleterious germline BRCA mutations as a maintenance therapy, metastatic castration-resistant prostate cancer with deleterious or suspected deleterious germline or somatic homologous recombination repair gene mutations who progressed following enzalutamide or abiraterone, as a maintenance therapy in recurrent epithelial ovarian, fallopian tube or primary peritoneal cancer and in epithelial ovarian, fallopian tube or primary peritoneal cancer with deleterious or suspected deleterious germline or somatic BRCA mutation, and in combination with Avastin (bevacizumab) as maintenance therapy in HDR defective epithelial ovarian, fallopian tube or primary peritoneal cancer as defined by deleterious or suspected deleterious BRCA mutation, and/or genomic instability (FDA.gov).

DrugClasses PARP Inhibitor (Pan) 19

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + Olaparib Abiraterone Olaparib 1 1
Abiraterone + Olaparib + Prednisone Abiraterone Olaparib Prednisone 0 1
Adavosertib + Olaparib Adavosertib Olaparib 1 4
AGI-5198 + Olaparib AGI-5198 Olaparib 1 0
Alpelisib + Olaparib Alpelisib Olaparib 1 1
AsiDNA + Olaparib AsiDNA Olaparib 7 0
Atezolizumab + Olaparib Atezolizumab Olaparib 0 1
AZD6482 + Olaparib AZD6482 Olaparib 0 0
AZD6738 + Olaparib AZD6738 Olaparib 1 9
AZD7648 + Olaparib AZD7648 Olaparib 4 1
Bemcentinib + Olaparib Bemcentinib Olaparib 0 0
Bendamustine + Olaparib Bendamustine Olaparib 1 0
Bevacizumab + Carboplatin + Olaparib + Paclitaxel + Pembrolizumab Bevacizumab Carboplatin Olaparib Paclitaxel Pembrolizumab 0 1
Bevacizumab + Carboplatin + Olaparib + Pembrolizumab Bevacizumab Carboplatin Olaparib Pembrolizumab 0 0
Bevacizumab + Cisplatin + Olaparib + Paclitaxel Bevacizumab Cisplatin Olaparib Paclitaxel 0 1
Bevacizumab + Durvalumab + Olaparib Bevacizumab Durvalumab Olaparib 0 2
Bevacizumab + Olaparib Bevacizumab Olaparib 0 0
Bevacizumab + Olaparib + Paclitaxel + Pembrolizumab Bevacizumab Olaparib Paclitaxel Pembrolizumab 0 0
BPTES + Olaparib BPTES Olaparib 1 0
Buparlisib + Olaparib Buparlisib Olaparib 1 1
Camptothecin + Olaparib Camptothecin Olaparib 1 0
Capivasertib + Olaparib Capivasertib Olaparib 4 2
Carboplatin + Durvalumab + Olaparib + Paclitaxel Carboplatin Durvalumab Olaparib Paclitaxel 0 1
Carboplatin + Gemcitabine + Olaparib + Pembrolizumab Carboplatin Gemcitabine Olaparib Pembrolizumab 0 1
Carboplatin + Olaparib Carboplatin Olaparib 0 0
Carboplatin + Olaparib + Paclitaxel + Pembrolizumab Carboplatin Olaparib Paclitaxel Pembrolizumab 0 1
Carboplatin + Olaparib + Pembrolizumab Carboplatin Olaparib Pembrolizumab 0 0
CB-839 + Olaparib CB-839 Olaparib 1 0
CCT241533 + Olaparib CCT241533 Olaparib 1 0
Cediranib + Durvalumab + Olaparib Cediranib Durvalumab Olaparib 1 0
Cediranib + Olaparib Cediranib Olaparib 1 12
Cetuximab + Olaparib Cetuximab Olaparib 0 1
Cisplatin + Olaparib Cisplatin Olaparib 1 0
Copanlisib + Durvalumab + Olaparib Copanlisib Durvalumab Olaparib 0 1
CRLX101 + Olaparib CRLX101 Olaparib 0 1
CYT01B + Olaparib CYT01B Olaparib 1 0
Daunorubicin + Olaparib Daunorubicin Olaparib 2 0
Dinaciclib + Olaparib Dinaciclib Olaparib 0 0
Dubermatinib + Olaparib Dubermatinib Olaparib 0 0
Durvalumab + Olaparib Durvalumab Olaparib 2 15
Durvalumab + Olaparib + Tremelimumab Durvalumab Olaparib Tremelimumab 0 1
Entinostat + Olaparib Entinostat Olaparib 0 1
Everolimus + Olaparib Everolimus Olaparib 0 0
Fludarabine + Olaparib Fludarabine Olaparib 1 0
Fulvestrant + Olaparib + Palbociclib Fulvestrant Olaparib Palbociclib 0 1
Infigratinib + Olaparib Infigratinib Olaparib 0 0
Irinotecan + Olaparib Irinotecan Olaparib 0 0
KU-0063794 + Olaparib KU-0063794 Olaparib 0 0
lutetium Lu 177 dotatate + Olaparib Olaparib lutetium Lu 177 dotatate 0 1
Olaparib Olaparib 47 65
Olaparib + Onalespib Olaparib Onalespib 0 1
Olaparib + Paclitaxel Olaparib Paclitaxel 4 0
Olaparib + Paclitaxel + Pembrolizumab Olaparib Paclitaxel Pembrolizumab 0 1
Olaparib + Pembrolizumab Olaparib Pembrolizumab 0 6
Olaparib + Prexasertib Olaparib Prexasertib 0 1
Olaparib + Radiotherapy Olaparib Radiotherapy 1 0
Olaparib + Ramucirumab Olaparib Ramucirumab 0 1
Olaparib + sapacitabine Olaparib sapacitabine 0 1
Olaparib + Selumetinib Olaparib Selumetinib 0 1
Olaparib + SN-38 Olaparib SN-38 1 0
Olaparib + SN-38 + Temozolomide Olaparib SN-38 Temozolomide 1 0
Olaparib + SR-4835 Olaparib SR-4835 0 0
Olaparib + Temozolomide Olaparib Temozolomide 5 3
Olaparib + Testosterone Enanthate Olaparib Testosterone Enanthate 0 1
Olaparib + Trabectedin Olaparib Trabectedin 1 1
Olaparib + Trametinib Olaparib Trametinib 0 0
Olaparib + Tremelimumab Olaparib Tremelimumab 0 2
Olaparib + Valproic acid Olaparib Valproic acid 1 0
Olaparib + VE-821 Olaparib VE-821 0 0
Olaparib + Vistusertib Olaparib Vistusertib 0 2
Olaparib + Vorinostat Olaparib Vorinostat 0 1
Olaparib + YU238259 Olaparib YU238259 0 0


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