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Drug Name Olaparib
Trade Name Lynparza
Synonyms AZD2281|KU-0059436
Drug Descriptions

Lynparza (olaparib) binds to and inhibits PARP, resulting in inhibition of DNA repair and lethality in homologous-recombination deficient cells, and may be a sensitizing agent for chemotherapy and radiotherapy (PMID: 25028150, PMID: 24225019). Lynparza (olaparib) is FDA approved for treatment of ERBB2 (HER2)-negative breast cancer with deleterious or suspected deleterious germline BRCA mutations, ovarian cancer with deleterious or suspected deleterious germline BRCA mutations and received 3 or more prior therapies, metastatic pancreatic adenocarcinoma with deleterious or suspected deleterious germline BRCA mutations as a maintenance therapy, metastatic castration-resistant prostate cancer (mCRPC) with deleterious or suspected deleterious germline or somatic homologous recombination repair gene mutations who progressed following enzalutamide or abiraterone, in combination with abiraterone in patients with mCRPC harboring deleterious or suspected deleterious BRCA mutations, as a maintenance therapy in recurrent epithelial ovarian, fallopian tube or primary peritoneal cancer and in epithelial ovarian, fallopian tube or primary peritoneal cancer with deleterious or suspected deleterious germline or somatic BRCA mutation, and in combination with Avastin (bevacizumab) as maintenance therapy in HDR defective epithelial ovarian, fallopian tube or primary peritoneal cancer as defined by deleterious or suspected deleterious BRCA mutation, and/or genomic instability (FDA.gov).

DrugClasses PARP Inhibitor (Pan) 30
CAS Registry Number 763113-22-0
NCIT ID C71721

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Olaparib Abemaciclib Olaparib 0 1
Abiraterone + Olaparib Abiraterone Olaparib 0 1
Abiraterone + Olaparib + Prednisone Abiraterone Olaparib Prednisone 0 2
Adagrasib + Olaparib Adagrasib Olaparib 0 1
Adavosertib + Olaparib Adavosertib Olaparib 0 4
ADCT-601 + Olaparib ADCT-601 Olaparib 0 0
Afatinib + Olaparib Afatinib Olaparib 0 0
AGI-5198 + Olaparib AGI-5198 Olaparib 1 0
Alpelisib + Olaparib Alpelisib Olaparib 0 3
Anlotinib + Dacomitinib + Olaparib + Pemetrexed Disodium + Temozolomide Anlotinib Dacomitinib Olaparib Pemetrexed Disodium Temozolomide 0 0
Anlotinib + Olaparib Anlotinib Olaparib 0 0
Anlotinib + Olaparib + Pembrolizumab Anlotinib Olaparib Pembrolizumab 0 0
ART6043 + Olaparib ART6043 Olaparib 0 1
AsiDNA + Olaparib AsiDNA Olaparib 0 1
Atezolizumab + Olaparib Atezolizumab Olaparib 0 1
AZ31 + Olaparib AZ31 Olaparib 0 0
AZD0156 + Olaparib AZD0156 Olaparib 0 0
AZD5153 + Olaparib AZD5153 Olaparib 0 0
AZD6482 + Olaparib AZD6482 Olaparib 1 0
AZD7648 + Olaparib AZD7648 Olaparib 3 1
BAY2701439 + Olaparib BAY2701439 Olaparib 0 0
Bemcentinib + Olaparib Bemcentinib Olaparib 0 0
Bendamustine + Olaparib Bendamustine Olaparib 1 0
Berzosertib + Olaparib Berzosertib Olaparib 0 0
Bevacizumab + Carboplatin + Olaparib + Paclitaxel + Pembrolizumab Bevacizumab Carboplatin Olaparib Paclitaxel Pembrolizumab 0 1
Bevacizumab + Carboplatin + Olaparib + Pembrolizumab Bevacizumab Carboplatin Olaparib Pembrolizumab 0 0
Bevacizumab + Cisplatin + Olaparib + Paclitaxel Bevacizumab Cisplatin Olaparib Paclitaxel 0 1
Bevacizumab + Durvalumab + Olaparib Bevacizumab Durvalumab Olaparib 0 2
Bevacizumab + Olaparib Bevacizumab Olaparib 0 3
Bevacizumab + Olaparib + Paclitaxel + Pembrolizumab Bevacizumab Olaparib Paclitaxel Pembrolizumab 0 0
Bevacizumab + Olaparib + Pembrolizumab Bevacizumab Olaparib Pembrolizumab 0 0
BPTES + Olaparib BPTES Olaparib 1 0
Buparlisib + Olaparib Buparlisib Olaparib 3 1
Camptothecin + Olaparib Camptothecin Olaparib 0 0
Capivasertib + Durvalumab + Olaparib Capivasertib Durvalumab Olaparib 0 0
Capivasertib + Olaparib Capivasertib Olaparib 0 3
Carboplatin + Durvalumab + Etoposide + Olaparib Carboplatin Durvalumab Etoposide Olaparib 0 1
Carboplatin + Durvalumab + Olaparib + Paclitaxel Carboplatin Durvalumab Olaparib Paclitaxel 0 1
Carboplatin + Gemcitabine + Olaparib + Pembrolizumab Carboplatin Gemcitabine Olaparib Pembrolizumab 0 1
Carboplatin + Olaparib Carboplatin Olaparib 0 0
Carboplatin + Olaparib + Paclitaxel Carboplatin Olaparib Paclitaxel 0 2
Carboplatin + Olaparib + Paclitaxel + Pembrolizumab Carboplatin Olaparib Paclitaxel Pembrolizumab 0 1
Carboplatin + Olaparib + Pembrolizumab Carboplatin Olaparib Pembrolizumab 0 1
CCS1477 + Olaparib CCS1477 Olaparib 0 1
CCT241533 + Olaparib CCT241533 Olaparib 0 0
Cediranib + Durvalumab + Olaparib Cediranib Durvalumab Olaparib 0 1
Cediranib + Olaparib Cediranib Olaparib 2 16
Cediranib + Olaparib + Triapine Cediranib Olaparib Triapine 0 0
Ceralasertib + Olaparib Ceralasertib Olaparib 11 12
Cetuximab + Olaparib Cetuximab Olaparib 0 1
CHIR99021 + Olaparib CHIR99021 Olaparib 0 0
Cisplatin + Olaparib Cisplatin Olaparib 1 0
Cisplatin + Olaparib + Pembrolizumab Cisplatin Olaparib Pembrolizumab 0 1
Cobicistat + Olaparib Cobicistat Olaparib 0 1
Copanlisib + Durvalumab + Olaparib Copanlisib Durvalumab Olaparib 0 1
Copanlisib + Olaparib Copanlisib Olaparib 0 1
CYH33 + Olaparib CYH33 Olaparib 0 1
CYT01B + Olaparib CYT01B Olaparib 0 0
Daunorubicin + Olaparib Daunorubicin Olaparib 2 0
Decitabine and Cedazuridine + Olaparib Decitabine and Cedazuridine Olaparib 0 1
Dinaciclib + Olaparib Dinaciclib Olaparib 0 0
Doxorubicin + Olaparib + Quizartinib Doxorubicin Olaparib Quizartinib 4 0
Dubermatinib + Olaparib Dubermatinib Olaparib 0 0
Durvalumab + Fulvestrant + Olaparib Durvalumab Fulvestrant Olaparib 0 1
Durvalumab + Olaparib Durvalumab Olaparib 3 24
Durvalumab + Olaparib + Tremelimumab Durvalumab Olaparib Tremelimumab 0 2
Elimusertib + Olaparib Elimusertib Olaparib 1 0
Encorafenib + Olaparib Encorafenib Olaparib 1 0
Entinostat + Olaparib Entinostat Olaparib 0 1
Etoposide + Olaparib Etoposide Olaparib 1 0
Everolimus + Olaparib Everolimus Olaparib 0 0
Fludarabine + Olaparib Fludarabine Olaparib 1 0
Fluorouracil + Irinotecan + Leucovorin + Olaparib + Oxaliplatin Fluorouracil Irinotecan Leucovorin Olaparib Oxaliplatin 0 0
Fulvestrant + Olaparib + Palbociclib Fulvestrant Olaparib Palbociclib 0 1
Gefitinib + Olaparib Gefitinib Olaparib 0 0
Goserelin + Olaparib Goserelin Olaparib 0 1
GSK126 + Olaparib GSK126 Olaparib 0 0
GSK2830371 + Olaparib GSK2830371 Olaparib 0 0
GSK2830371 + Olaparib + Radiotherapy GSK2830371 Olaparib Radiotherapy 0 0
Hu5F9-G4 + Olaparib Hu5F9-G4 Olaparib 0 1
Hydroxyurea + Olaparib + Rituximab Hydroxyurea Olaparib Rituximab 1 0
INCB057643 + Olaparib INCB057643 Olaparib 0 0
Infigratinib + Olaparib Infigratinib Olaparib 0 0
Irinotecan + Olaparib Irinotecan Olaparib 1 1
ISM3091 + Olaparib ISM3091 Olaparib 0 0
JNJ 38877605 + Olaparib JNJ 38877605 Olaparib 0 0
KU-0063794 + Olaparib KU-0063794 Olaparib 0 0
KU-55933 + Olaparib KU-55933 Olaparib 0 0
Leuprolide + Olaparib Leuprolide Olaparib 0 1
Lorlatinib + Olaparib Lorlatinib Olaparib 0 0
lutetium Lu 177 dotatate + Olaparib Olaparib lutetium Lu 177 dotatate 0 2
lutetium Lu 177 vipivotide tetraxetan + Olaparib Olaparib lutetium Lu 177 vipivotide tetraxetan 0 1
LY2090314 + Olaparib LY2090314 Olaparib 0 0
M4076 + Olaparib M4076 Olaparib 0 0
Mirvetuximab Soravtansine + Olaparib Mirvetuximab Soravtansine Olaparib 0 1
MK-8776 + Olaparib MK-8776 Olaparib 0 0
Navitoclax + Olaparib Navitoclax Olaparib 0 1
Nivolumab + Olaparib Nivolumab Olaparib 0 0
NLG207 + Olaparib NLG207 Olaparib 0 2
NUV-868 + Olaparib NUV-868 Olaparib 0 1
Olaparib Olaparib 180 108
Olaparib + Onalespib Olaparib Onalespib 0 1
Olaparib + Paclitaxel Olaparib Paclitaxel 2 0
Olaparib + Paclitaxel + Pembrolizumab Olaparib Paclitaxel Pembrolizumab 0 1
Olaparib + Pamiparib + Temozolomide Olaparib Pamiparib Temozolomide 0 1
Olaparib + Patritumab deruxtecan Olaparib Patritumab deruxtecan 0 1
Olaparib + Pembrolizumab Olaparib Pembrolizumab 0 27
Olaparib + Pembrolizumab + Temozolomide Olaparib Pembrolizumab Temozolomide 0 2
Olaparib + PHI-101 Olaparib PHI-101 0 0
Olaparib + PLX2853 Olaparib PLX2853 0 1
Olaparib + Prexasertib Olaparib Prexasertib 0 1
Olaparib + Quizartinib Olaparib Quizartinib 4 0
Olaparib + Radiotherapy Olaparib Radiotherapy 4 0
Olaparib + Radium Ra 223 dichloride Olaparib Radium Ra 223 dichloride 0 0
Olaparib + Ramucirumab Olaparib Ramucirumab 0 1
Olaparib + Rituximab Olaparib Rituximab 1 0
Olaparib + RP-3500 Olaparib RP-3500 0 2
Olaparib + Sapacitabine Olaparib Sapacitabine 0 1
Olaparib + Selumetinib Olaparib Selumetinib 0 4
Olaparib + SN-38 Olaparib SN-38 0 0
Olaparib + SN-38 + Temozolomide Olaparib SN-38 Temozolomide 0 0
Olaparib + SP-002 Olaparib SP-002 0 0
Olaparib + SR-4835 Olaparib SR-4835 0 0
Olaparib + Telaglenastat Olaparib Telaglenastat 1 0
Olaparib + Temozolomide Olaparib Temozolomide 6 7
Olaparib + Testosterone Enanthate Olaparib Testosterone Enanthate 0 1
Olaparib + THZ1 Olaparib THZ1 0 0
Olaparib + TNG348 Olaparib TNG348 0 1
Olaparib + Trabectedin Olaparib Trabectedin 0 3
Olaparib + Trametinib Olaparib Trametinib 0 0
Olaparib + Trametinib + unspecified PD-L1 antibody Olaparib Trametinib unspecified PD-L1 antibody 0 0
Olaparib + Trastuzumab Olaparib Trastuzumab 0 1
Olaparib + Trastuzumab deruxtecan Olaparib Trastuzumab deruxtecan 0 1
Olaparib + Tremelimumab Olaparib Tremelimumab 0 2
Olaparib + Triapine Olaparib Triapine 0 0
Olaparib + Triptorelin Olaparib Triptorelin 0 1
Olaparib + unspecified PD-L1 antibody Olaparib unspecified PD-L1 antibody 0 0
Olaparib + USP7-797 Olaparib USP7-797 0 0
Olaparib + Valproic acid Olaparib Valproic acid 1 0
Olaparib + VE-821 Olaparib VE-821 0 0
Olaparib + Vistusertib Olaparib Vistusertib 0 1
Olaparib + Vorinostat Olaparib Vorinostat 0 1
Olaparib + XmAb20717 Olaparib XmAb20717 0 1
Olaparib + YU238259 Olaparib YU238259 0 0
Olaparib + ZSQ836 Olaparib ZSQ836 0 0


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