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Drug Name | Adagrasib |
Trade Name | |
Synonyms | MRTX849|MRTX-849|MRTX 849 |
Drug Descriptions |
Adagrasib (MRTX849) covalently binds to and stabilizes GDP-bound KRAS G12C, therefore prevents KRAS downstream signaling, resulting in tumor growth inhibition (PMID: 31658955). |
DrugClasses | KRAS G12C inhibitor 18 |
CAS Registry Number | 2326521-71-3 |
NCIT ID | C157493 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Adagrasib | Adagrasib | 0 | 3 |
Adagrasib + Afatinib | Adagrasib Afatinib | 0 | 1 |
Adagrasib + BI 1701963 | Adagrasib BI 1701963 | 0 | 1 |
Adagrasib + Buparlisib | Adagrasib Buparlisib | 0 | 0 |
Adagrasib + Cetuximab | Adagrasib Cetuximab | 0 | 2 |
Adagrasib + Everolimus | Adagrasib Everolimus | 0 | 0 |
Adagrasib + Palbociclib | Adagrasib Palbociclib | 0 | 1 |
Adagrasib + Pembrolizumab | Adagrasib Pembrolizumab | 0 | 2 |
Adagrasib + Pictilisib | Adagrasib Pictilisib | 0 | 0 |
Adagrasib + RMC-4550 | Adagrasib RMC-4550 | 0 | 0 |
Adagrasib + RO5126766 | Adagrasib RO5126766 | 0 | 1 |
Adagrasib + TNO155 | Adagrasib TNO155 | 0 | 1 |
Adagrasib + unspecified PD-1 antibody | Adagrasib unspecified PD-1 antibody | 0 | 0 |
Adagrasib + Vistusertib | Adagrasib Vistusertib | 0 | 0 |