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| Drug Name | Adagrasib |
| Trade Name | Krazati |
| Synonyms | MRTX849|MRTX-849|MRTX 849 |
| Drug Descriptions |
Krazati (adagrasib) covalently binds to and stabilizes GDP-bound KRAS G12C, thereby preventing KRAS downstream signaling and potentially inhibiting tumor growth (PMID: 31658955). Krazati (adagrasib) is FDA approved for use in patients with locally advanced or metastatic non-small cell lung cancer harboring KRAS G12C who have received one or more prior therapy (FDA.gov). |
| DrugClasses | KRAS G12C inhibitor 32 |
| CAS Registry Number | 2326521-71-3 |
| NCIT ID | C157493 |
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