Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Adagrasib
Trade Name
Synonyms MRTX849|MRTX-849|MRTX 849
Drug Descriptions

Adagrasib (MRTX849) covalently binds to and stabilizes GDP-bound KRAS G12C, therefore prevents KRAS downstream signaling, resulting in tumor growth inhibition (PMID: 31658955).

DrugClasses KRAS G12C inhibitor 27
CAS Registry Number 2326521-71-3
NCIT ID C157493


  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"


  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Adagrasib Adagrasib 0 3
Adagrasib + Afatinib Adagrasib Afatinib 0 1
Adagrasib + BI 1701963 Adagrasib BI 1701963 0 1
Adagrasib + Buparlisib Adagrasib Buparlisib 0 0
Adagrasib + Cetuximab Adagrasib Cetuximab 0 2
Adagrasib + ERAS-601 Adagrasib ERAS-601 0 0
Adagrasib + Everolimus Adagrasib Everolimus 0 0
Adagrasib + MRTX0902 Adagrasib MRTX0902 0 1
Adagrasib + Palbociclib Adagrasib Palbociclib 0 1
Adagrasib + Pembrolizumab Adagrasib Pembrolizumab 0 3
Adagrasib + Pictilisib Adagrasib Pictilisib 0 0
Adagrasib + RMC-4550 Adagrasib RMC-4550 0 0
Adagrasib + RO5126766 Adagrasib RO5126766 0 1
Adagrasib + Selinexor Adagrasib Selinexor 0 0
Adagrasib + TNO155 Adagrasib TNO155 0 1
Adagrasib + unspecified PD-1 antibody Adagrasib unspecified PD-1 antibody 0 0
Adagrasib + Vistusertib Adagrasib Vistusertib 0 0

Additional content available in CKB BOOST