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Drug Name Adagrasib
Trade Name Krazati
Synonyms MRTX849|MRTX-849|MRTX 849
Drug Descriptions

Krazati (adagrasib) covalently binds to and stabilizes GDP-bound KRAS G12C, thereby preventing KRAS downstream signaling and potentially inhibiting tumor growth (PMID: 31658955). Krazati (adagrasib) is FDA approved for use in patients with locally advanced or metastatic non-small cell lung cancer harboring KRAS G12C who have received one or more prior therapy (FDA.gov).

DrugClasses KRAS G12C inhibitor 33
CAS Registry Number 2326521-71-3
NCIT ID C157493

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Adagrasib Adagrasib 0 9
Adagrasib + Afatinib Adagrasib Afatinib 0 1
Adagrasib + BBP-398 Adagrasib BBP-398 0 1
Adagrasib + BBP-398 + Cetuximab Adagrasib BBP-398 Cetuximab 0 1
Adagrasib + BI 1701963 Adagrasib BI 1701963 0 1
Adagrasib + Buparlisib Adagrasib Buparlisib 0 0
Adagrasib + Cemiplimab + Cetuximab Adagrasib Cemiplimab Cetuximab 0 0
Adagrasib + Cetuximab Adagrasib Cetuximab 0 2
Adagrasib + Cetuximab + Irinotecan Adagrasib Cetuximab Irinotecan 0 1
Adagrasib + Crizotinib Adagrasib Crizotinib 0 0
Adagrasib + Durvalumab Adagrasib Durvalumab 0 1
Adagrasib + Eltrombopag Adagrasib Eltrombopag 0 0
Adagrasib + Entrectinib Adagrasib Entrectinib 0 0
Adagrasib + ERAS-601 Adagrasib ERAS-601 0 0
Adagrasib + Everolimus Adagrasib Everolimus 0 0
Adagrasib + INCB099280 Adagrasib INCB099280 0 1
Adagrasib + KO-2806 Adagrasib KO-2806 0 1
Adagrasib + KPT-9274 Adagrasib KPT-9274 0 0
Adagrasib + Lonafarnib Adagrasib Lonafarnib 0 0
Adagrasib + MRTX0902 Adagrasib MRTX0902 0 1
Adagrasib + MRTX1719 Adagrasib MRTX1719 0 0
Adagrasib + Nab-rapamycin Adagrasib Nab-rapamycin 0 1
Adagrasib + Nivolumab Adagrasib Nivolumab 0 1
Adagrasib + Olaparib Adagrasib Olaparib 0 1
Adagrasib + Palbociclib Adagrasib Palbociclib 0 1
Adagrasib + Panitumumab Adagrasib Panitumumab 0 0
Adagrasib + Pembrolizumab Adagrasib Pembrolizumab 0 3
Adagrasib + Pictilisib Adagrasib Pictilisib 0 0
Adagrasib + RMC-4550 Adagrasib RMC-4550 0 0
Adagrasib + RMC-4630 Adagrasib RMC-4630 0 1
Adagrasib + RO5126766 Adagrasib RO5126766 0 1
Adagrasib + Selinexor Adagrasib Selinexor 0 0
Adagrasib + Tipifarnib Adagrasib Tipifarnib 0 0
Adagrasib + TNO155 Adagrasib TNO155 0 1
Adagrasib + Tunlametinib Adagrasib Tunlametinib 0 0
Adagrasib + unspecified PD-1 antibody Adagrasib unspecified PD-1 antibody 0 0
Adagrasib + Vistusertib Adagrasib Vistusertib 0 0


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