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Drug Name Afatinib
Trade Name Gilotrif
Synonyms BIBW 2992|Giotrif
Drug Descriptions

Gilotrif (afatinib) is a second-generation pan-Egfr inhibitor with activity against EGFR T790M and EGFR exon 19 and 21 deletions, and also inhibits ERBB2 (HER2), ERBB3 (HER3), ERBB4 (HER4) (PMID: 24435321, PMID: 25505694). Gilotrif (afatinib) is FDA approved for use in non-small cell lung cancer patients harboring non-resistant EGFR mutations, including exon 19 deletions, L858R, S768I, G719X, and L861Q, and for patients with metastatic squamous NSCLC (FDA.gov).

DrugClasses EGFR Inhibitor (Pan) 61 EGFR Inhibitor 2nd gen 5 HER inhibitor (Pan) 6
CAS Registry Number 850140-72-6
NCIT ID C66940

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Adagrasib + Afatinib Adagrasib Afatinib 0 1
Afatinib Afatinib 3 33
Afatinib + Alectinib Afatinib Alectinib 2 0
Afatinib + Alpelisib Afatinib Alpelisib 3 0
Afatinib + AMG 337 AMG 337 Afatinib 0 0
Afatinib + Anlotinib Afatinib Anlotinib 0 0
Afatinib + Aumolertinib Afatinib Aumolertinib 0 0
Afatinib + AZD4625 AZD4625 Afatinib 0 0
Afatinib + Bevacizumab Afatinib Bevacizumab 0 0
Afatinib + BI 882370 Afatinib BI 882370 1 0
Afatinib + Binimetinib Afatinib Binimetinib 0 0
Afatinib + BTX-6654 Afatinib BTX-6654 0 0
Afatinib + BTX-7312 Afatinib BTX-7312 0 0
Afatinib + Cabozantinib Afatinib Cabozantinib 0 0
Afatinib + Capmatinib Afatinib Capmatinib 0 0
Afatinib + Carboplatin + Paclitaxel Afatinib Carboplatin Paclitaxel 0 1
Afatinib + Carboplatin + Pemetrexed Disodium Afatinib Carboplatin Pemetrexed Disodium 0 1
Afatinib + Cetuximab Afatinib Cetuximab 0 2
Afatinib + Cetuximab + Sirolimus Afatinib Cetuximab Sirolimus 0 0
Afatinib + CI-1040 Afatinib CI-1040 0 0
Afatinib + Cisplatin + Pemetrexed Disodium Afatinib Cisplatin Pemetrexed Disodium 0 0
Afatinib + Crizotinib Afatinib Crizotinib 2 0
Afatinib + Crizotinib + Trametinib Afatinib Crizotinib Trametinib 0 0
Afatinib + Dabrafenib Afatinib Dabrafenib 0 0
Afatinib + Dasatinib Afatinib Dasatinib 0 1
Afatinib + DCC-3116 Afatinib DCC-3116 0 0
Afatinib + Denosumab Afatinib Denosumab 0 0
Afatinib + Duligotuzumab Afatinib Duligotuzumab 0 0
Afatinib + Entrectinib Afatinib Entrectinib 0 0
Afatinib + Futibatinib Afatinib Futibatinib 0 0
Afatinib + Ganetespib Afatinib Ganetespib 0 0
Afatinib + Imatinib Afatinib Imatinib 0 0
Afatinib + Infigratinib Afatinib Infigratinib 0 0
Afatinib + JMT101 Afatinib JMT101 0 0
Afatinib + Loperamide Afatinib Loperamide 0 1
Afatinib + Lorlatinib Afatinib Lorlatinib 1 0
Afatinib + Metformin Afatinib Metformin 0 0
Afatinib + MRTX-1133 Afatinib MRTX-1133 0 0
Afatinib + Necitumumab Afatinib Necitumumab 0 1
Afatinib + Nimotuzumab Afatinib Nimotuzumab 0 0
Afatinib + Nivolumab Afatinib Nivolumab 0 1
Afatinib + Olaparib Afatinib Olaparib 0 0
Afatinib + Osimertinib Afatinib Osimertinib 0 1
Afatinib + Paclitaxel Afatinib Paclitaxel 0 3
Afatinib + Panitumumab Afatinib Panitumumab 0 0
Afatinib + Pembrolizumab Afatinib Pembrolizumab 0 2
Afatinib + Pemetrexed Disodium Afatinib Pemetrexed Disodium 0 0
Afatinib + Pemigatinib Afatinib Pemigatinib 0 1
Afatinib + Pralsetinib Afatinib Pralsetinib 0 0
Afatinib + Prednisone Afatinib Prednisone 0 1
Afatinib + Pyrotinib Afatinib Pyrotinib 0 0
Afatinib + Radiotherapy Afatinib Radiotherapy 0 0
Afatinib + rhEndostatin Afatinib rhEndostatin 0 0
Afatinib + Rivoceranib Afatinib Rivoceranib 0 0
Afatinib + RO5126766 Afatinib RO5126766 0 0
Afatinib + Rociletinib Afatinib Rociletinib 0 0
Afatinib + Saracatinib Afatinib Saracatinib 0 0
Afatinib + Savolitinib Afatinib Savolitinib 0 0
Afatinib + Selpercatinib Afatinib Selpercatinib 0 0
Afatinib + Selumetinib Afatinib Selumetinib 0 0
Afatinib + Sotorasib Afatinib Sotorasib 0 1
Afatinib + Tivantinib Afatinib Tivantinib 0 0
Afatinib + Trametinib Afatinib Trametinib 0 0
Afatinib + Trastuzumab Afatinib Trastuzumab 0 0
Afatinib + UNC0642 Afatinib UNC0642 0 0
Afatinib + Verteporfin Afatinib Verteporfin 0 0
Afatinib + Vinorelbine Afatinib Vinorelbine 0 0
Afatinib + VT104 Afatinib VT104 0 0
Afatinib + Zenocutuzumab Afatinib Zenocutuzumab 0 1


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