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Drug Name Afatinib
Trade Name Gilotrif
Synonyms BIBW 2992
Drug Descriptions

Gilotrif (afatinib) is a second-generation pan-Egfr inhibitor with activity against EGFR T790M and EGFR exon 19 and 21 deletions, and also inhibits ERBB2 (HER2), ERBB3 (HER3), ERBB4 (HER4) (PMID: 24435321, PMID: 25505694). Gilotrif (afatinib) is FDA approved for use in non-small cell lung cancer patients harboring non-resistant EGFR mutations, including exon 19 deletions, L858R, S768I, G719X, and L861Q, and for patients with metastatic squamous NSCLC (FDA.gov).

DrugClasses EGFR Inhibitor (Pan) 46 EGFR Inhibitor 2nd gen 3 HER inhibitor (Pan) 5 HER3 Inhibitor 2

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Afatinib Afatinib 87 25
Afatinib + Alectinib Afatinib Alectinib 1 0
Afatinib + AMG 337 AMG 337 Afatinib 0 0
Afatinib + AMG 510 AMG 510 Afatinib 0 0
Afatinib + Bevacizumab Afatinib Bevacizumab 0 0
Afatinib + BI 882370 Afatinib BI 882370 1 0
Afatinib + BLU-667 Afatinib BLU-667 0 0
Afatinib + Cabozantinib Afatinib Cabozantinib 0 0
Afatinib + Capmatinib Afatinib Capmatinib 0 0
Afatinib + Carboplatin + Paclitaxel Afatinib Carboplatin Paclitaxel 0 1
Afatinib + Cetuximab Afatinib Cetuximab 0 2
Afatinib + Cetuximab + Sirolimus Afatinib Cetuximab Sirolimus 0 0
Afatinib + Cisplatin + Pemetrexed Disodium Afatinib Cisplatin Pemetrexed Disodium 1 0
Afatinib + Crizotinib Afatinib Crizotinib 0 0
Afatinib + Crizotinib + Trametinib Afatinib Crizotinib Trametinib 0 0
Afatinib + Dabrafenib Afatinib Dabrafenib 0 0
Afatinib + Dasatinib Afatinib Dasatinib 0 1
Afatinib + Ganetespib Afatinib Ganetespib 0 0
Afatinib + Imatinib Afatinib Imatinib 0 0
Afatinib + Loperamide Afatinib Loperamide 0 1
Afatinib + MRTX849 Afatinib MRTX849 0 0
Afatinib + Necitumumab Afatinib Necitumumab 0 1
Afatinib + Nimotuzumab Afatinib Nimotuzumab 1 0
Afatinib + Nivolumab Afatinib Nivolumab 0 1
Afatinib + Paclitaxel Afatinib Paclitaxel 0 2
Afatinib + Pembrolizumab Afatinib Pembrolizumab 0 2
Afatinib + Radiotherapy Afatinib Radiotherapy 0 0
Afatinib + Rivoceranib Afatinib Rivoceranib 1 0
Afatinib + Saracatinib Afatinib Saracatinib 0 0
Afatinib + Selumetinib Afatinib Selumetinib 0 0
Afatinib + Trametinib Afatinib Trametinib 0 0
Afatinib + Trastuzumab Afatinib Trastuzumab 5 0
Afatinib + Vinorelbine Afatinib Vinorelbine 2 0


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