Drug Detail


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Drug Name Necitumumab
Trade Name Portrazza
Synonyms IMC-11F8
Drug Descriptions

Portrazza (necitumumab) is a fully human IgG1 mAb targeting EGFR, leading to the inhibition of downstream targets in the EGFR pathway, and thereby inhibiting cellular proliferation and invasion (PMID: 21154125). Portrazza (necitumumab) is approved for patients with metastatic squamous non-small cell lung cancer (FDA.gov).

DrugClasses EGFR Antibody 57
CAS Registry Number 906805-06-9
NCIT ID C88281


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Afatinib + Necitumumab Afatinib Necitumumab 0 1
Brigatinib + Necitumumab Brigatinib Necitumumab 0 0
Carboplatin + Gemcitabine + Necitumumab Carboplatin Gemcitabine Necitumumab 0 1
Carboplatin + Nab-paclitaxel + Necitumumab Carboplatin Nab-paclitaxel Necitumumab 0 1
Cisplatin + Gemcitabine + Necitumumab Cisplatin Gemcitabine Necitumumab 0 1
Cisplatin + Necitumumab + Pemetrexed Disodium Cisplatin Necitumumab Pemetrexed Disodium 0 0
Fluorouracil + Leucovorin + Necitumumab + Oxaliplatin Fluorouracil Leucovorin Necitumumab Oxaliplatin 0 0
LY3300054 + Necitumumab LY3300054 Necitumumab 0 1
Necitumumab Necitumumab 0 5
Necitumumab + Osimertinib Necitumumab Osimertinib 0 3
Necitumumab + Osimertinib + Trastuzumab Necitumumab Osimertinib Trastuzumab 0 1
Necitumumab + Pembrolizumab Necitumumab Pembrolizumab 0 0

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