Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Osimertinib
Trade Name Tagrisso
Synonyms AZD9291
Drug Descriptions

Tagrisso (osimertinib) is a third-generation EGFR inhibitor that selectively binds mutant forms of the EGF receptor, inhibiting downstream signaling and potentially reducing cell proliferation and growth in EGFR overexpressing tumors (PMID: 29151359). Tagrisso (osimertinib) is FDA-approved for use as adjuvant therapy after resection in patients with non-small cell lung cancer (NSCLC) harboring EFGFR exon 19 deletion or L858R, as first-line therapy in patients with metastatic NSCLC harboring EFGFR exon 19 deletion or L858R, and for treatment in patients with metastatic NSCLC harboring EGFR T790M whose disease progressed after EGFR TKI therapy (FDA.gov).

DrugClasses EGFR Inhibitor 3rd gen 20
CAS Registry Number 1421373-65-0
NCIT ID C116377

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Osimertinib Abemaciclib Osimertinib 0 1
Alectinib + Osimertinib Alectinib Osimertinib 0 1
Alisertib + Osimertinib Alisertib Osimertinib 0 2
Axitinib + Osimertinib Axitinib Osimertinib 0 0
AZD3759 + Osimertinib AZD3759 Osimertinib 0 0
AZD4205 + Osimertinib AZD4205 Osimertinib 1 0
BC2059 + Osimertinib BC2059 Osimertinib 0 1
Bevacizumab + Osimertinib Bevacizumab Osimertinib 0 3
Birabresib + Osimertinib Birabresib Osimertinib 0 0
BLZ945 + Osimertinib BLZ945 Osimertinib 0 0
Bosutinib + Osimertinib + PF-573228 Bosutinib Osimertinib PF-573228 0 0
Bozitinib + Osimertinib Bozitinib Osimertinib 0 1
Buparlisib + Osimertinib Buparlisib Osimertinib 0 0
Cabozantinib + Osimertinib Cabozantinib Osimertinib 0 0
Capmatinib + Osimertinib Capmatinib Osimertinib 0 0
Carboplatin + Etoposide + Osimertinib Carboplatin Etoposide Osimertinib 0 1
Carboplatin + Osimertinib + Pemetrexed Disodium Carboplatin Osimertinib Pemetrexed Disodium 0 3
Cetuximab + Osimertinib Cetuximab Osimertinib 0 0
Cisplatin + Etoposide + Osimertinib Cisplatin Etoposide Osimertinib 0 1
Cisplatin + Osimertinib + Pemetrexed Disodium Cisplatin Osimertinib Pemetrexed Disodium 0 2
Crizotinib + Osimertinib Crizotinib Osimertinib 0 0
Dabrafenib + Osimertinib Dabrafenib Osimertinib 0 0
Dacomitinib + Osimertinib Dacomitinib Osimertinib 0 1
Dasatinib + Osimertinib Dasatinib Osimertinib 0 1
DS-1205b + Osimertinib DS-1205b Osimertinib 0 0
DS-1205c + Osimertinib DS-1205c Osimertinib 0 1
Durvalumab + Osimertinib Durvalumab Osimertinib 0 1
EAI045 + Osimertinib EAI045 Osimertinib 0 0
Erlotinib + Osimertinib Erlotinib Osimertinib 0 0
G1T38 + Osimertinib G1T38 Osimertinib 0 1
Gefitinib + Osimertinib Gefitinib Osimertinib 0 2
Gilteritinib + Osimertinib Gilteritinib Osimertinib 0 0
GSK2334470 + Osimertinib GSK2334470 Osimertinib 0 0
IACS-13909 + Osimertinib IACS-13909 Osimertinib 0 0
Imatinib + Osimertinib Imatinib Osimertinib 0 0
Ipilimumab + Osimertinib Ipilimumab Osimertinib 0 1
Itacitinib + Osimertinib Itacitinib Osimertinib 0 1
Itraconazole + Osimertinib Itraconazole Osimertinib 0 1
JBJ-04-125-02 + Osimertinib JBJ-04-125-02 Osimertinib 0 0
JNJ-61186372 + Osimertinib JNJ-61186372 Osimertinib 0 0
JQ1 + Osimertinib JQ1 Osimertinib 0 0
MK8033 + Osimertinib MK8033 Osimertinib 0 0
MRX-2843 + Osimertinib MRX-2843 Osimertinib 0 1
Navitoclax + Osimertinib Navitoclax Osimertinib 0 1
Necitumumab + Osimertinib Necitumumab Osimertinib 0 3
Necitumumab + Osimertinib + Trastuzumab Necitumumab Osimertinib Trastuzumab 0 1
Nintedanib + Osimertinib Nintedanib Osimertinib 0 0
Niraparib + Osimertinib Niraparib Osimertinib 0 1
Oleclumab + Osimertinib Oleclumab Osimertinib 0 1
Osimertinib Osimertinib 14 37
Osimertinib + Panobinostat Osimertinib Panobinostat 0 0
Osimertinib + Pemetrexed Disodium Osimertinib Pemetrexed Disodium 0 1
Osimertinib + PF-573228 + Saracatinib Osimertinib PF-573228 Saracatinib 0 0
Osimertinib + Pralsetinib Osimertinib Pralsetinib 0 0
Osimertinib + RAF709 + SCH772984 Osimertinib RAF709 SCH772984 0 0
Osimertinib + RAF709 + Trametinib Osimertinib RAF709 Trametinib 0 0
Osimertinib + Ramucirumab Osimertinib Ramucirumab 0 3
Osimertinib + Rifampin Osimertinib Rifampin 0 1
Osimertinib + RMC-4630 Osimertinib RMC-4630 0 1
Osimertinib + Sapanisertib Osimertinib Sapanisertib 0 2
Osimertinib + Saracatinib Osimertinib Saracatinib 0 0
Osimertinib + Savolitinib Osimertinib Savolitinib 0 4
Osimertinib + SCH772984 Osimertinib SCH772984 0 0
Osimertinib + SCH772984 + Trametinib Osimertinib SCH772984 Trametinib 0 0
Osimertinib + Selpercatinib Osimertinib Selpercatinib 0 1
Osimertinib + Selumetinib Osimertinib Selumetinib 0 2
Osimertinib + Simvastatin Osimertinib Simvastatin 0 1
Osimertinib + Sunitinib Osimertinib Sunitinib 0 0
Osimertinib + TAK-632 Osimertinib TAK-632 0 0
Osimertinib + Telaglenastat Osimertinib Telaglenastat 0 1
Osimertinib + Temozolomide Osimertinib Temozolomide 0 1
Osimertinib + Tepotinib Osimertinib Tepotinib 0 1
Osimertinib + Trametinib Osimertinib Trametinib 0 0
Osimertinib + U3-1402 Osimertinib U3-1402 0 1
Osimertinib + Vorinostat Osimertinib Vorinostat 0 0


Additional content available in CKB BOOST