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Drug Name Osimertinib
Trade Name Tagrisso
Synonyms AZD9291
Drug Descriptions

Tagrisso (osimertinib) is a third-generation EGFR inhibitor that selectively binds mutant forms of the EGF receptor, inhibiting downstream signaling and potentially reducing cell proliferation and growth in EGFR overexpressing tumors (PMID: 29151359). Tagrisso (osimertinib) is FDA-approved for use as adjuvant therapy after resection in patients with non-small cell lung cancer (NSCLC) harboring EGFR exon 19 deletion or L858R, as first-line therapy in patients with metastatic NSCLC harboring EGFR exon 19 deletion or L858R, in combination with pemetrexed and platinum-based chemotherapy as first-line therapy in patients with locally advanced or metastatic NSCLC harboring EGFR exon 19 deletion or L858R, and for treatment in patients with metastatic NSCLC harboring EGFR T790M whose disease progressed after EGFR TKI therapy (FDA.gov).

DrugClasses EGFR Inhibitor 3rd gen 26
CAS Registry Number 1421373-65-0
NCIT ID C116377

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Therapy Name Drugs Efficacy Evidence Clinical Trials
ABBV-637 + Osimertinib ABBV-637 Osimertinib 0 1
Abemaciclib + Osimertinib Abemaciclib Osimertinib 0 1
Ado-trastuzumab emtansine + Osimertinib Ado-trastuzumab emtansine Osimertinib 0 0
Afatinib + Osimertinib Afatinib Osimertinib 0 1
Alectinib + Osimertinib Alectinib Osimertinib 0 1
Alisertib + Osimertinib Alisertib Osimertinib 0 2
Alpelisib + AZD4547 + Osimertinib AZD4547 Alpelisib Osimertinib 0 0
Amivantamab-vmjw + Osimertinib Amivantamab-vmjw Osimertinib 0 1
AMT-562 + Osimertinib AMT-562 Osimertinib 0 0
Anlotinib + Osimertinib Anlotinib Osimertinib 0 0
APG-1252 + Osimertinib APG-1252 Osimertinib 0 0
APG-2449 + Osimertinib APG-2449 Osimertinib 0 0
ARS1620 + Osimertinib ARS1620 Osimertinib 0 0
Axitinib + Osimertinib Axitinib Osimertinib 0 0
AZD3759 + Osimertinib AZD3759 Osimertinib 0 0
AZD4547 + Osimertinib AZD4547 Osimertinib 0 0
AZD9592 + Osimertinib AZD9592 Osimertinib 0 1
BAY-293 + Osimertinib BAY-293 Osimertinib 0 0
BAY-293 + Osimertinib + RMC-4550 BAY-293 Osimertinib RMC-4550 0 0
BBT-176 + Osimertinib BBT-176 Osimertinib 0 0
BC2059 + Osimertinib BC2059 Osimertinib 0 1
Bevacizumab + Brigatinib + Osimertinib Bevacizumab Brigatinib Osimertinib 0 0
Bevacizumab + Osimertinib Bevacizumab Osimertinib 0 3
BI-4732 + Osimertinib BI-4732 Osimertinib 0 0
Birabresib + Osimertinib Birabresib Osimertinib 0 0
BLU-701 + Osimertinib BLU-701 Osimertinib 0 1
BLU-945 + Osimertinib BLU-945 Osimertinib 0 1
BLZ945 + Osimertinib BLZ945 Osimertinib 0 0
Bosutinib + Osimertinib Bosutinib Osimertinib 0 0
Bosutinib + Osimertinib + PF-573228 Bosutinib Osimertinib PF-573228 0 0
Brigatinib + Osimertinib Brigatinib Osimertinib 0 0
Buparlisib + Osimertinib Buparlisib Osimertinib 0 0
BX-795 + Osimertinib BX-795 Osimertinib 0 0
Cabozantinib + Osimertinib Cabozantinib Osimertinib 0 0
Capivasertib + Osimertinib Capivasertib Osimertinib 0 0
Capmatinib + Osimertinib Capmatinib Osimertinib 0 2
Capmatinib + Osimertinib + Ramucirumab Capmatinib Osimertinib Ramucirumab 0 1
Carboplatin + Etoposide + Osimertinib Carboplatin Etoposide Osimertinib 0 1
Carboplatin + Osimertinib + Pemetrexed Disodium Carboplatin Osimertinib Pemetrexed Disodium 0 6
Carotuximab + Osimertinib Carotuximab Osimertinib 0 1
Cetuximab + Osimertinib Cetuximab Osimertinib 0 0
Cetuximab + Osimertinib + Tucatinib Cetuximab Osimertinib Tucatinib 0 1
Cisplatin + Etoposide + Osimertinib Cisplatin Etoposide Osimertinib 0 1
Cisplatin + Osimertinib + Pemetrexed Disodium Cisplatin Osimertinib Pemetrexed Disodium 0 4
Cobicistat + Osimertinib Cobicistat Osimertinib 0 0
Crizotinib + Osimertinib Crizotinib Osimertinib 0 0
Dabrafenib + Osimertinib Dabrafenib Osimertinib 0 0
Dabrafenib + Osimertinib + Trametinib Dabrafenib Osimertinib Trametinib 0 0
Dacomitinib + Osimertinib Dacomitinib Osimertinib 0 1
Dasatinib + Osimertinib Dasatinib Osimertinib 0 1
Datopotamab deruxtecan + Osimertinib Datopotamab deruxtecan Osimertinib 0 1
DCC-3116 + Osimertinib DCC-3116 Osimertinib 0 0
DS-1205b + Osimertinib DS-1205b Osimertinib 0 0
DS-1205c + Osimertinib DS-1205c Osimertinib 0 1
Durvalumab + Osimertinib Durvalumab Osimertinib 0 1
EAI045 + Osimertinib EAI045 Osimertinib 0 0
EMB-01 + Osimertinib EMB-01 Osimertinib 0 1
ERAS-007 + Osimertinib ERAS-007 Osimertinib 0 1
Erdafitinib + Osimertinib Erdafitinib Osimertinib 0 0
Erdafitinib + Osimertinib + Trametinib Erdafitinib Osimertinib Trametinib 0 0
Erlotinib + Osimertinib Erlotinib Osimertinib 0 0
Everolimus + Osimertinib Everolimus Osimertinib 0 0
Futibatinib + Osimertinib Futibatinib Osimertinib 0 0
G1T38 + Osimertinib G1T38 Osimertinib 0 1
GDC-1971 + Osimertinib GDC-1971 Osimertinib 0 1
Gefitinib + Osimertinib Gefitinib Osimertinib 0 2
Gilteritinib + Osimertinib Gilteritinib Osimertinib 0 0
Golidocitinib + Osimertinib Golidocitinib Osimertinib 0 0
GSK2334470 + Osimertinib GSK2334470 Osimertinib 0 0
IACS-13909 + Osimertinib IACS-13909 Osimertinib 0 0
IAG933 + Osimertinib IAG933 Osimertinib 0 0
Icotinib + Osimertinib Icotinib Osimertinib 0 0
Imatinib + Osimertinib Imatinib Osimertinib 0 0
Ipilimumab + Osimertinib Ipilimumab Osimertinib 0 1
Itacitinib + Osimertinib Itacitinib Osimertinib 0 1
Itraconazole + Osimertinib Itraconazole Osimertinib 0 1
JBJ-04-125-02 + Osimertinib JBJ-04-125-02 Osimertinib 0 0
JBJ-09-063 + Osimertinib JBJ-09-063 Osimertinib 0 0
JMT101 + Osimertinib JMT101 Osimertinib 0 0
JQ1 + Osimertinib JQ1 Osimertinib 0 0
Leelamine + Osimertinib Leelamine Osimertinib 0 0
LY3009120 + Osimertinib LY3009120 Osimertinib 0 0
LY3295668 + Osimertinib LY3295668 Osimertinib 0 1
Minnelide + Osimertinib Minnelide Osimertinib 0 1
MK8033 + Osimertinib MK8033 Osimertinib 0 0
MRTX0902 + Osimertinib MRTX0902 Osimertinib 0 0
MRX-2843 + Osimertinib MRX-2843 Osimertinib 0 1
MSA-2 + Osimertinib MSA-2 Osimertinib 0 0
Navitoclax + Osimertinib Navitoclax Osimertinib 0 1
Necitumumab + Osimertinib Necitumumab Osimertinib 0 3
Necitumumab + Osimertinib + Trastuzumab Necitumumab Osimertinib Trastuzumab 0 1
Nintedanib + Osimertinib Nintedanib Osimertinib 0 0
Niraparib + Osimertinib Niraparib Osimertinib 0 1
Oleclumab + Osimertinib Oleclumab Osimertinib 0 1
Osimertinib Osimertinib 15 52
Osimertinib + Panitumumab Osimertinib Panitumumab 0 0
Osimertinib + Panobinostat Osimertinib Panobinostat 0 0
Osimertinib + Patritumab deruxtecan Osimertinib Patritumab deruxtecan 0 1
Osimertinib + Pemetrexed Disodium Osimertinib Pemetrexed Disodium 0 1
Osimertinib + PF-573228 + Saracatinib Osimertinib PF-573228 Saracatinib 0 0
Osimertinib + Pralsetinib Osimertinib Pralsetinib 0 0
Osimertinib + Pyrotinib Osimertinib Pyrotinib 0 0
Osimertinib + Quaratusugene Ozeplasmid Osimertinib Quaratusugene Ozeplasmid 0 1
Osimertinib + RAF709 Osimertinib RAF709 0 0
Osimertinib + RAF709 + SCH772984 Osimertinib RAF709 SCH772984 0 0
Osimertinib + RAF709 + Trametinib Osimertinib RAF709 Trametinib 0 0
Osimertinib + Ramucirumab Osimertinib Ramucirumab 0 3
Osimertinib + Repotrectinib Osimertinib Repotrectinib 0 1
Osimertinib + Rifampin Osimertinib Rifampin 0 1
Osimertinib + Rivoceranib Osimertinib Rivoceranib 0 0
Osimertinib + RMC-4550 Osimertinib RMC-4550 0 0
Osimertinib + RMC-4630 Osimertinib RMC-4630 0 1
Osimertinib + Sapanisertib Osimertinib Sapanisertib 0 2
Osimertinib + Saracatinib Osimertinib Saracatinib 0 0
Osimertinib + Savolitinib Osimertinib Savolitinib 0 5
Osimertinib + SCH772984 Osimertinib SCH772984 0 0
Osimertinib + SCH772984 + Trametinib Osimertinib SCH772984 Trametinib 0 0
Osimertinib + Selpercatinib Osimertinib Selpercatinib 0 1
Osimertinib + Selumetinib Osimertinib Selumetinib 0 2
Osimertinib + SHP099 Osimertinib SHP099 0 0
Osimertinib + SHP099 + SX-682 Osimertinib SHP099 SX-682 0 0
Osimertinib + Simvastatin Osimertinib Simvastatin 0 1
Osimertinib + Sirolimus Osimertinib Sirolimus 0 0
Osimertinib + Sotorasib Osimertinib Sotorasib 0 0
Osimertinib + Sunitinib Osimertinib Sunitinib 0 0
Osimertinib + TAK-632 Osimertinib TAK-632 0 0
Osimertinib + Telaglenastat Osimertinib Telaglenastat 0 1
Osimertinib + Telisotuzumab vedotin Osimertinib Telisotuzumab vedotin 0 0
Osimertinib + Temozolomide Osimertinib Temozolomide 0 1
Osimertinib + Tepotinib Osimertinib Tepotinib 0 2
Osimertinib + Tipifarnib Osimertinib Tipifarnib 0 1
Osimertinib + TNO155 Osimertinib TNO155 0 0
Osimertinib + Trametinib Osimertinib Trametinib 0 0
Osimertinib + Trastuzumab Osimertinib Trastuzumab 0 0
Osimertinib + Vebreltinib Osimertinib Vebreltinib 0 1
Osimertinib + Vemurafenib Osimertinib Vemurafenib 0 0
Osimertinib + Vistusertib Osimertinib Vistusertib 0 0
Osimertinib + Vorinostat Osimertinib Vorinostat 0 0
Osimertinib + VT104 Osimertinib VT104 0 0
Osimertinib + VT3989 Osimertinib VT3989 0 0


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