Drug Detail

Drug Name Osimertinib
Trade Name Tagrisso
Synonyms AZD9291
Drug Descriptions

Tagrisso (osimertinib) is a third-generation EGFR inhibitor that selectively binds mutant forms of the EGF receptor, inhibiting downstream signaling and potentially reducing cell proliferation and growth in EGFR overexpressing tumors (PMID: 29151359). Tagrisso (osimertinib) is FDA-approved for use in patients with non-small cell lung cancer harboring EGFR exon 19 deletions, L858R, or T790M (FDA.gov).

DrugClasses EGFR Inhibitor 3rd gen 17

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Alectinib + Osimertinib Alectinib Osimertinib 0 0
Bevacizumab + Osimertinib Bevacizumab Osimertinib 0 2
BLU-667 + Osimertinib BLU-667 Osimertinib 0 0
Bosutinib + Osimertinib + PF-573228 Bosutinib Osimertinib PF-573228 1 0
Buparlisib + Osimertinib Buparlisib Osimertinib 3 0
Cabozantinib + Osimertinib Cabozantinib Osimertinib 2 0
Carboplatin + Etoposide + Osimertinib Carboplatin Etoposide Osimertinib 0 1
CB-839 + Osimertinib CB-839 Osimertinib 0 1
Cetuximab + Osimertinib Cetuximab Osimertinib 1 0
Cisplatin + Etoposide + Osimertinib Cisplatin Etoposide Osimertinib 0 1
Crizotinib + Osimertinib Crizotinib Osimertinib 2 0
Dabrafenib + Osimertinib Dabrafenib Osimertinib 1 0
Dacomitinib + Osimertinib Dacomitinib Osimertinib 0 1
Dasatinib + Osimertinib Dasatinib Osimertinib 3 1
DS-1205b + Osimertinib DS-1205b Osimertinib 1 0
DS-1205c + Osimertinib DS-1205c Osimertinib 0 1
Durvalumab + Osimertinib Durvalumab Osimertinib 0 1
G1T38 + Osimertinib G1T38 Osimertinib 0 1
Gefitinib + Osimertinib Gefitinib Osimertinib 0 2
GSK2334470 + Osimertinib GSK2334470 Osimertinib 1 0
Imatinib + Osimertinib Imatinib Osimertinib 0 0
Itacitinib + Osimertinib Itacitinib Osimertinib 0 1
Itraconazole + Osimertinib Itraconazole Osimertinib 0 1
JNJ-61186372 + Osimertinib JNJ-61186372 Osimertinib 1 0
JQ1 + Osimertinib JQ1 Osimertinib 1 0
Navitoclax + Osimertinib Navitoclax Osimertinib 0 1
Necitumumab + Osimertinib Necitumumab Osimertinib 0 3
Niraparib + Osimertinib Niraparib Osimertinib 0 1
Oleclumab + Osimertinib Oleclumab Osimertinib 0 1
Osimertinib Osimertinib 210 30
Osimertinib + PF-573228 + Saracatinib Osimertinib PF-573228 Saracatinib 1 0
Osimertinib + Ramucirumab Osimertinib Ramucirumab 2 2
Osimertinib + Rifampin Osimertinib Rifampin 0 1
Osimertinib + Sapanisertib Osimertinib Sapanisertib 0 1
Osimertinib + Saracatinib Osimertinib Saracatinib 1 0
Osimertinib + Savolitinib Osimertinib Savolitinib 3 3
Osimertinib + Selumetinib Osimertinib Selumetinib 7 2
Osimertinib + Simvastatin Osimertinib Simvastatin 0 1
Osimertinib + TAK-632 Osimertinib TAK-632 1 0
Osimertinib + Tepotinib Osimertinib Tepotinib 0 1


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