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Drug Name Osimertinib
Trade Name Tagrisso
Synonyms AZD9291
Drug Descriptions

Tagrisso (osimertinib) is a third-generation EGFR inhibitor that selectively binds mutant forms of the EGF receptor, inhibiting downstream signaling and potentially reducing cell proliferation and growth in EGFR overexpressing tumors (PMID: 29151359). Tagrisso (osimertinib) is FDA-approved for use as adjuvant therapy after resection in patients with non-small cell lung cancer (NSCLC) harboring EFGFR exon 19 deletion or L858R, as first-line therapy in patients with metastatic NSCLC harboring EFGFR exon 19 deletion or L858R, and for treatment in patients with metastatic NSCLC harboring EGFR T790M whose disease progressed after EGFR TKI therapy (FDA.gov).

DrugClasses EGFR Inhibitor 3rd gen 21
CAS Registry Number 1421373-65-0
NCIT ID C116377

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Therapy Name Drugs Efficacy Evidence Clinical Trials
ABBV-637 + Osimertinib ABBV-637 Osimertinib 0 1
Abemaciclib + Osimertinib Abemaciclib Osimertinib 0 1
Afatinib + Osimertinib Afatinib Osimertinib 0 1
Alectinib + Osimertinib Alectinib Osimertinib 0 1
Alisertib + Osimertinib Alisertib Osimertinib 0 2
amivantamab-vmjw + Osimertinib Osimertinib amivantamab-vmjw 0 0
Axitinib + Osimertinib Axitinib Osimertinib 0 0
AZD3759 + Osimertinib AZD3759 Osimertinib 0 0
AZD4205 + Osimertinib AZD4205 Osimertinib 0 0
BAY-293 + Osimertinib BAY-293 Osimertinib 0 0
BAY-293 + Osimertinib + RMC-4550 BAY-293 Osimertinib RMC-4550 0 0
BC2059 + Osimertinib BC2059 Osimertinib 0 1
Bevacizumab + Osimertinib Bevacizumab Osimertinib 0 3
Birabresib + Osimertinib Birabresib Osimertinib 0 0
BLZ945 + Osimertinib BLZ945 Osimertinib 0 0
Bosutinib + Osimertinib Bosutinib Osimertinib 0 0
Bosutinib + Osimertinib + PF-573228 Bosutinib Osimertinib PF-573228 0 0
Bozitinib + Osimertinib Bozitinib Osimertinib 0 1
Buparlisib + Osimertinib Buparlisib Osimertinib 0 0
Cabozantinib + Osimertinib Cabozantinib Osimertinib 0 0
Capmatinib + Osimertinib Capmatinib Osimertinib 0 0
Carboplatin + Etoposide + Osimertinib Carboplatin Etoposide Osimertinib 0 1
Carboplatin + Osimertinib + Pemetrexed Disodium Carboplatin Osimertinib Pemetrexed Disodium 0 4
Cetuximab + Osimertinib Cetuximab Osimertinib 0 0
Cisplatin + Etoposide + Osimertinib Cisplatin Etoposide Osimertinib 0 1
Cisplatin + Osimertinib + Pemetrexed Disodium Cisplatin Osimertinib Pemetrexed Disodium 0 3
Crizotinib + Osimertinib Crizotinib Osimertinib 0 0
Dabrafenib + Osimertinib Dabrafenib Osimertinib 0 0
Dabrafenib + Osimertinib + Trametinib Dabrafenib Osimertinib Trametinib 0 0
Dacomitinib + Osimertinib Dacomitinib Osimertinib 0 1
Dasatinib + Osimertinib Dasatinib Osimertinib 0 1
DS-1205b + Osimertinib DS-1205b Osimertinib 0 0
DS-1205c + Osimertinib DS-1205c Osimertinib 0 1
Durvalumab + Osimertinib Durvalumab Osimertinib 0 1
EAI045 + Osimertinib EAI045 Osimertinib 0 0
ERAS-007 + Osimertinib ERAS-007 Osimertinib 0 1
Erlotinib + Osimertinib Erlotinib Osimertinib 0 0
Everolimus + Osimertinib Everolimus Osimertinib 0 0
G1T38 + Osimertinib G1T38 Osimertinib 0 1
Gefitinib + Osimertinib Gefitinib Osimertinib 0 2
Gilteritinib + Osimertinib Gilteritinib Osimertinib 0 0
GSK2334470 + Osimertinib GSK2334470 Osimertinib 0 0
IACS-13909 + Osimertinib IACS-13909 Osimertinib 0 0
Imatinib + Osimertinib Imatinib Osimertinib 0 0
Ipilimumab + Osimertinib Ipilimumab Osimertinib 0 1
Itacitinib + Osimertinib Itacitinib Osimertinib 0 1
Itraconazole + Osimertinib Itraconazole Osimertinib 0 1
JBJ-04-125-02 + Osimertinib JBJ-04-125-02 Osimertinib 0 0
JQ1 + Osimertinib JQ1 Osimertinib 0 0
LY3295668 + Osimertinib LY3295668 Osimertinib 0 1
MK8033 + Osimertinib MK8033 Osimertinib 0 0
MRX-2843 + Osimertinib MRX-2843 Osimertinib 0 1
Navitoclax + Osimertinib Navitoclax Osimertinib 0 1
Necitumumab + Osimertinib Necitumumab Osimertinib 0 3
Necitumumab + Osimertinib + Trastuzumab Necitumumab Osimertinib Trastuzumab 0 1
Nintedanib + Osimertinib Nintedanib Osimertinib 0 0
Niraparib + Osimertinib Niraparib Osimertinib 0 1
Oleclumab + Osimertinib Oleclumab Osimertinib 0 1
Osimertinib Osimertinib 14 43
Osimertinib + Panobinostat Osimertinib Panobinostat 0 0
Osimertinib + Pemetrexed Disodium Osimertinib Pemetrexed Disodium 0 1
Osimertinib + PF-573228 + Saracatinib Osimertinib PF-573228 Saracatinib 0 0
Osimertinib + Pralsetinib Osimertinib Pralsetinib 0 0
Osimertinib + Quaratusugene Ozeplasmid Osimertinib Quaratusugene Ozeplasmid 0 1
Osimertinib + RAF709 + SCH772984 Osimertinib RAF709 SCH772984 0 0
Osimertinib + RAF709 + Trametinib Osimertinib RAF709 Trametinib 0 0
Osimertinib + Ramucirumab Osimertinib Ramucirumab 0 3
Osimertinib + Repotrectinib Osimertinib Repotrectinib 0 1
Osimertinib + Rifampin Osimertinib Rifampin 0 1
Osimertinib + RMC-4550 Osimertinib RMC-4550 0 0
Osimertinib + RMC-4630 Osimertinib RMC-4630 0 1
Osimertinib + Sapanisertib Osimertinib Sapanisertib 0 2
Osimertinib + Saracatinib Osimertinib Saracatinib 0 0
Osimertinib + Savolitinib Osimertinib Savolitinib 0 4
Osimertinib + SCH772984 Osimertinib SCH772984 0 0
Osimertinib + SCH772984 + Trametinib Osimertinib SCH772984 Trametinib 0 0
Osimertinib + Selpercatinib Osimertinib Selpercatinib 0 1
Osimertinib + Selumetinib Osimertinib Selumetinib 0 2
Osimertinib + SHP099 Osimertinib SHP099 0 0
Osimertinib + Simvastatin Osimertinib Simvastatin 0 1
Osimertinib + Sirolimus Osimertinib Sirolimus 0 0
Osimertinib + Sunitinib Osimertinib Sunitinib 0 0
Osimertinib + TAK-632 Osimertinib TAK-632 0 0
Osimertinib + Telaglenastat Osimertinib Telaglenastat 0 1
Osimertinib + Temozolomide Osimertinib Temozolomide 0 1
Osimertinib + Tepotinib Osimertinib Tepotinib 0 1
Osimertinib + Trametinib Osimertinib Trametinib 0 0
Osimertinib + U3-1402 Osimertinib U3-1402 0 1
Osimertinib + Vistusertib Osimertinib Vistusertib 0 0
Osimertinib + Vorinostat Osimertinib Vorinostat 0 0


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