Drug Detail


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Drug Name Nintedanib
Trade Name Ofev
Synonyms BIBF 1120|Vargatef|BIBF 1120
Drug Descriptions

Ofev (nintedanib) is a triple angiokinase inhibitor that acts by blocking VEGFR, FGFR, RET, and PDGFR, thereby preventing tumorigenesis (PMID: 24947258, PMID: 24561444). Ofev (nintedanib) is FDA approved for use in patients with idiopathic pulmonary fibrosis (FDA.gov).

DrugClasses FGFR Inhibitor (Pan) 26 PDGFR Inhibitor (Pan) 30 RET Inhibitor 52 VEGFR Inhibitor (Pan) 36
CAS Registry Number 656247-17-5
NCIT ID C62765


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Alpelisib + Nintedanib Alpelisib Nintedanib 2 0
Azacitidine + Nintedanib Azacitidine Nintedanib 0 1
Bevacizumab + Nintedanib Bevacizumab Nintedanib 0 1
BI 885578 + Nintedanib BI 885578 Nintedanib 0 0
Capecitabine + Nintedanib Capecitabine Nintedanib 0 2
Carboplatin + Nintedanib + Paclitaxel Carboplatin Nintedanib Paclitaxel 0 0
Cisplatin + Docetaxel + Nintedanib Cisplatin Docetaxel Nintedanib 0 1
Docetaxel + Nintedanib Docetaxel Nintedanib 0 0
Gemcitabine + Nab-paclitaxel + Nintedanib Gemcitabine Nab-paclitaxel Nintedanib 0 1
Ipilimumab + Nintedanib + Nivolumab Ipilimumab Nintedanib Nivolumab 0 1
Letrozole + Nintedanib Letrozole Nintedanib 0 0
Nintedanib Nintedanib 35 18
Nintedanib + Osimertinib Nintedanib Osimertinib 0 0
Nintedanib + Pembrolizumab Nintedanib Pembrolizumab 0 1
Nintedanib + Pictilisib Nintedanib Pictilisib 3 0
Nintedanib + Trametinib Nintedanib Trametinib 0 0
Nintedanib + Trametinib + unspecified PD-L1 antibody Nintedanib Trametinib unspecified PD-L1 antibody 0 0

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