Drug Detail


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Drug Name Nintedanib
Trade Name Ofev
Synonyms BIBF 1120|Vargatef|BIBF 1120
Drug Descriptions

Ofev (nintedanib) is a triple angiokinase inhibitor that acts by blocking VEGFR, FGFR, RET, and PDGFR, thereby preventing tumorigenesis (PMID: 24947258, PMID: 24561444). Ofev (nintedanib) is FDA approved for use in patients with idiopathic pulmonary fibrosis (FDA.gov).

DrugClasses FGFR Inhibitor (Pan) 18 PDGFR Inhibitor (Pan) 27 RET Inhibitor 39 VEGFR Inhibitor (Pan) 32


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Azacitidine + Nintedanib Azacitidine Nintedanib 0 1
Bevacizumab + Nintedanib Bevacizumab Nintedanib 0 1
BI 885578 + Nintedanib BI 885578 Nintedanib 0 0
Capecitabine + Nintedanib Capecitabine Nintedanib 0 2
Carboplatin + Nintedanib + Paclitaxel Carboplatin Nintedanib Paclitaxel 1 0
Cisplatin + Docetaxel + Nintedanib Cisplatin Docetaxel Nintedanib 0 1
Docetaxel + Nintedanib Docetaxel Nintedanib 2 0
Gemcitabine + Nab-paclitaxel + Nintedanib Gemcitabine Nab-paclitaxel Nintedanib 0 1
Ipilimumab + Nintedanib + Nivolumab Ipilimumab Nintedanib Nivolumab 0 1
Nintedanib Nintedanib 21 17

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