Drug Detail

Drug Name Azacitidine
Trade Name Vidaza
Synonyms azacytidine|CC-486|5-azacytidine|5-AC|U-18496
Drug Descriptions

Vidaza (azacitidine) is a cytidine analog that incorporates into DNA and RNA and binds to DNA methyltransferases (DNMTs), resulting in DNMT degradation and decreased DNA methylation, and leading to increased tumor cell death (PMID: 28159832, PMID: 28067760). Vidaza (azacitidine) is FDA-approved for use in patients with some subtypes of myelodysplastic syndrome (FDA.gov).

DrugClasses DNMT inhibitor (Pan) 5

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Therapy Name Drugs Efficacy Evidence Clinical Trials
ABBV-075 + Azacitidine ABBV-075 Azacitidine 2 0
APR-246 + Azacitidine APR-246 Azacitidine 0 3
ARGX-110 + Azacitidine ARGX-110 Azacitidine 0 1
Avelumab + Azacitidine Avelumab Azacitidine 0 2
Avelumab + Azacitidine + PF-04518600 Avelumab Azacitidine PF-04518600 0 1
Avelumab + Azacitidine + Utomilumab Avelumab Azacitidine Utomilumab 0 1
Azacitidine Azacitidine 4 46
Azacitidine + BI 836858 Azacitidine BI 836858 0 1
Azacitidine + CC-223 Azacitidine CC-223 0 1
Azacitidine + Cladribine + Cytarabine + Venetoclax Azacitidine Cladribine Cytarabine Venetoclax 0 1
Azacitidine + Cytarabine + Fludarabine + MLN4924 Azacitidine Cytarabine Fludarabine MLN4924 0 1
Azacitidine + DCLL9718S Azacitidine DCLL9718S 0 1
Azacitidine + Decitabine Azacitidine Decitabine 0 1
Azacitidine + Decitabine + PF-06747143 Azacitidine Decitabine PF-06747143 0 1
Azacitidine + Durvalumab Azacitidine Durvalumab 0 5
Azacitidine + Durvalumab + Romidepsin Azacitidine Durvalumab Romidepsin 0 1
Azacitidine + Durvalumab + Tremelimumab Azacitidine Durvalumab Tremelimumab 0 1
Azacitidine + Enasidenib Azacitidine Enasidenib 0 4
Azacitidine + Entinostat Azacitidine Entinostat 1 2
Azacitidine + Entospletinib Azacitidine Entospletinib 0 1
Azacitidine + Epacadostat + Pembrolizumab Azacitidine Epacadostat Pembrolizumab 0 1
Azacitidine + FT-1101 Azacitidine FT-1101 0 1
Azacitidine + FT-2102 Azacitidine FT-2102 0 2
Azacitidine + Gemcitabine + Vorinostat Azacitidine Gemcitabine Vorinostat 0 1
Azacitidine + Gilteritinib Azacitidine Gilteritinib 0 1
Azacitidine + Glasdegib Azacitidine Glasdegib 0 3
Azacitidine + GSK3326595 Azacitidine GSK3326595 0 1
Azacitidine + Hu5F9-G4 Azacitidine Hu5F9-G4 0 1
Azacitidine + Ibrutinib Azacitidine Ibrutinib 0 1
Azacitidine + Ivosidenib Azacitidine Ivosidenib 0 2
Azacitidine + Leuprolide + Tretinoin Azacitidine Leuprolide Tretinoin 0 1
Azacitidine + MBG453 Azacitidine MBG453 0 1
Azacitidine + Midostaurin Azacitidine Midostaurin 1 2
Azacitidine + MLN4924 Azacitidine MLN4924 0 3
Azacitidine + MLN4924 + Venetoclax Azacitidine MLN4924 Venetoclax 0 1
Azacitidine + Nab-paclitaxel Azacitidine Nab-paclitaxel 0 1
Azacitidine + Nintedanib Azacitidine Nintedanib 0 1
Azacitidine + Nivolumab Azacitidine Nivolumab 1 3
Azacitidine + Panobinostat Azacitidine Panobinostat 0 0
Azacitidine + Pembrolizumab Azacitidine Pembrolizumab 0 7
Azacitidine + Pembrolizumab + Romidepsin Azacitidine Pembrolizumab Romidepsin 0 1
Azacitidine + PF-04518600 Azacitidine PF-04518600 0 1
Azacitidine + Ponatinib Azacitidine Ponatinib 0 1
Azacitidine + Pracinostat Azacitidine Pracinostat 0 2
Azacitidine + Quizartinib Azacitidine Quizartinib 1 1
Azacitidine + Regorafenib Azacitidine Regorafenib 0 1
Azacitidine + Romidepsin Azacitidine Romidepsin 0 2
Azacitidine + Selumetinib Azacitidine Selumetinib 0 1
Azacitidine + Sirolimus Azacitidine Sirolimus 0 1
Azacitidine + Sorafenib Azacitidine Sorafenib 2 1
Azacitidine + Tamibarotene Azacitidine Tamibarotene 0 1
Azacitidine + Venetoclax Azacitidine Venetoclax 1 7
Azacitidine + Vorinostat Azacitidine Vorinostat 0 1