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Drug Name Enasidenib
Trade Name Idhifa
Synonyms AG-221
Drug Descriptions

Idhifa (enasidenib) inhibits IDH2 to prevent 2HG formation, which may promote differentiation and inhibit proliferation of cancer cells (PMID: 28280273). Idhifa (enasidenib) is FDA-approved for use in patients with relapsed or refractory acute myeloid leukemia harboring an IDH2 mutation (R140Q/L/G/W, R172K/M/G/S/W) (FDA.gov).

DrugClasses IDH2 Inhibitor 2

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Azacitidine + Enasidenib Azacitidine Enasidenib 0 4
CPX-351 + Enasidenib CPX-351 Enasidenib 0 2
Cytarabine + Daunorubicin + Enasidenib Cytarabine Daunorubicin Enasidenib 0 1
Cytarabine + Enasidenib Cytarabine Enasidenib 0 1
Cytarabine + Enasidenib + Idarubicin Cytarabine Enasidenib Idarubicin 0 1
Dexamethasone + Enasidenib + Ixazomib + Pomalidomide Dexamethasone Enasidenib Ixazomib Pomalidomide 0 1
Enasidenib Enasidenib 19 8
Enasidenib + Etoposide + Mitoxantrone Enasidenib Etoposide Mitoxantrone 0 1
Enasidenib + Quizartinib Enasidenib Quizartinib 1 0
Enasidenib + Ruxolitinib Enasidenib Ruxolitinib 0 1
Enasidenib + Venetoclax Enasidenib Venetoclax 0 1


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