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Drug Name Quizartinib
Trade Name
Synonyms Vanflyta|AC220
Drug Descriptions

Vanflyta (Quizartinib) targets both wild-type and mutant FLT3 containing activating internal tandem duplications, as well as PDGFRA, RET, and KIT, which may induce apoptosis and inhibit tumor growth (PMID: 19654408, PMID: 23497317).

DrugClasses FLT3 Inhibitor 54 KIT Inhibitor 50 PDGFR-alpha Inhibitor 9 RET Inhibitor 39

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Azacitidine + Quizartinib Azacitidine Quizartinib 1 2
Cladribine + Cytarabine + Idarubicin + Quizartinib Cladribine Cytarabine Idarubicin Quizartinib 0 1
CPX-351 + Quizartinib CPX-351 Quizartinib 0 2
Cytarabine + Daunorubicin + Fludarabine + Hydrocortisone + Methotrexate + Quizartinib Cytarabine Daunorubicin Fludarabine Hydrocortisone Methotrexate Quizartinib 0 1
Cytarabine + Daunorubicin + Fludarabine + Methotrexate + Prednisolone + Quizartinib Cytarabine Daunorubicin Fludarabine Methotrexate Prednisolone Quizartinib 0 1
Cytarabine + Daunorubicin + Idarubicin + Quizartinib Cytarabine Daunorubicin Idarubicin Quizartinib 0 1
Cytarabine + Daunorubicin + Quizartinib Cytarabine Daunorubicin Quizartinib 2 0
Cytarabine + Fludarabine + Methotrexate + Prednisolone + Quizartinib Cytarabine Fludarabine Methotrexate Prednisolone Quizartinib 0 1
Cytarabine + Quizartinib Cytarabine Quizartinib 1 1
Decitabine + Quizartinib Decitabine Quizartinib 0 0
Enasidenib + Quizartinib Enasidenib Quizartinib 1 0
FLT3/CD3 Fabsc antibody + Quizartinib FLT3/CD3 Fabsc antibody Quizartinib 1 0
Milademetan Tosylate + Quizartinib Milademetan Tosylate Quizartinib 0 1
Palbociclib + Quizartinib Palbociclib Quizartinib 1 0
PD173074 + Quizartinib PD173074 Quizartinib 0 0
PRT062607 + Quizartinib PRT062607 Quizartinib 2 0
Quizartinib Quizartinib 31 3
Quizartinib + SGN-CD123A Quizartinib SGN-CD123A 0 0
Quizartinib + Venetoclax Quizartinib Venetoclax 0 1


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