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Drug Name Quizartinib
Trade Name Vanflyta
Synonyms AC220
Drug Descriptions

Vanflyta (quizartinib) is a small molecule that selectively inhibits FLT3, which may induce apoptosis and inhibit tumor growth (PMID: 19654408, PMID: 23497317). Vanflyta (quizartinib) is FDA-approved for use in combination with standard cytarabine and anthracycline induction and cytarabine consolidation, and as maintenance monotherapy following consolidation chemotherapy, in patients with newly diagnosed acute myeloid leukemia harboring FLT3 ITD mutations (FDA.gov).

DrugClasses FLT3 Inhibitor 66
CAS Registry Number 950769-58-1
NCIT ID C68936

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Therapy Name Drugs Efficacy Evidence Clinical Trials
APG-2575 + Quizartinib APG-2575 Quizartinib 0 0
Azacitidine + Quizartinib Azacitidine Quizartinib 1 2
Azacitidine + Quizartinib + Venetoclax Azacitidine Quizartinib Venetoclax 0 1
Cladribine + Cytarabine + Idarubicin + Quizartinib Cladribine Cytarabine Idarubicin Quizartinib 0 1
CPX-351 + Quizartinib CPX-351 Quizartinib 0 2
Cytarabine + Daunorubicin + Fludarabine + Hydrocortisone + Methotrexate + Quizartinib Cytarabine Daunorubicin Fludarabine Hydrocortisone Methotrexate Quizartinib 0 1
Cytarabine + Daunorubicin + Fludarabine + Methotrexate + Prednisolone + Quizartinib Cytarabine Daunorubicin Fludarabine Methotrexate Prednisolone Quizartinib 0 1
Cytarabine + Daunorubicin + Idarubicin + Quizartinib Cytarabine Daunorubicin Idarubicin Quizartinib 0 1
Cytarabine + Daunorubicin + Quizartinib Cytarabine Daunorubicin Quizartinib 3 0
Cytarabine + Filgrastim + Fludarabine + Idarubicin + Quizartinib Cytarabine Filgrastim Fludarabine Idarubicin Quizartinib 0 0
Cytarabine + Fludarabine + Idarubicin + Lenograstim + Quizartinib Cytarabine Fludarabine Idarubicin Lenograstim Quizartinib 0 1
Cytarabine + Fludarabine + Methotrexate + Prednisolone + Quizartinib Cytarabine Fludarabine Methotrexate Prednisolone Quizartinib 0 1
Cytarabine + Idarubicin + Quizartinib Cytarabine Idarubicin Quizartinib 0 1
Cytarabine + Quizartinib Cytarabine Quizartinib 3 2
Cytarabine + Quizartinib + Venetoclax Cytarabine Quizartinib Venetoclax 0 1
Decitabine + Quizartinib Decitabine Quizartinib 0 0
Decitabine + Quizartinib + Venetoclax Decitabine Quizartinib Venetoclax 1 1
Doxorubicin + Olaparib + Quizartinib Doxorubicin Olaparib Quizartinib 4 0
Enasidenib + Quizartinib Enasidenib Quizartinib 1 0
FLT3/CD3 Fabsc antibody + Quizartinib FLT3/CD3 Fabsc antibody Quizartinib 1 0
MI-503 + Quizartinib MI-503 Quizartinib 0 0
Milademetan + Quizartinib Milademetan Quizartinib 0 1
Olaparib + Quizartinib Olaparib Quizartinib 4 0
Palbociclib + Quizartinib Palbociclib Quizartinib 1 0
PD173074 + Quizartinib PD173074 Quizartinib 0 0
PF-04691502 + Quizartinib PF-04691502 Quizartinib 1 0
PRT062607 + Quizartinib PRT062607 Quizartinib 2 0
Quizartinib Quizartinib 101 4
Quizartinib + SGN-CD123A Quizartinib SGN-CD123A 0 0
Quizartinib + Talazoparib Quizartinib Talazoparib 3 0
Quizartinib + Venetoclax Quizartinib Venetoclax 0 1
Quizartinib + VTP50469 Quizartinib VTP50469 0 0


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