Drug Detail

Drug Name Decitabine
Trade Name Dacogen
Synonyms 5-aza-2-deoxycytidine
Drug Descriptions

Dacogen (decitabine) is cytidine analog that incorporates into DNA and forms covalent bonds with DNA methyltransferases (DNMTs), resulting in decreased DNMT activity and hypomethylation, and potentially leading to reduced tumor growth (PMID: 28159832, PMID: 25130173). Dacogen (decitabine) is FDA approved for use in patients with myelodysplastic syndromes (FDA.gov).

DrugClasses DNMT inhibitor (Pan) 5

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Therapy Name Drugs Efficacy Evidence Clinical Trials
AMG 232 + Decitabine AMG 232 Decitabine 0 1
AR-42 + Decitabine AR-42 Decitabine 0 1
Arsenic trioxide + Decitabine Arsenic trioxide Decitabine 0 1
Avelumab + Decitabine Avelumab Decitabine 0 1
Azacitidine + Decitabine Azacitidine Decitabine 0 1
Azacitidine + Decitabine + PF-06747143 Azacitidine Decitabine PF-06747143 0 1
BI 836858 + Decitabine BI 836858 Decitabine 1 1
Bortezomib + Decitabine + Sorafenib Bortezomib Decitabine Sorafenib 0 1
Carboplatin + Decitabine Carboplatin Decitabine 0 1
Celecoxib + Decitabine + Tetrahydrouridine Celecoxib Decitabine Tetrahydrouridine 0 1
Cytarabine + Daunorubicin + Decitabine Cytarabine Daunorubicin Decitabine 0 1
Cytarabine + Decitabine Cytarabine Decitabine 0 3
Cytarabine + Decitabine + omacetaxine mepesuccinate Cytarabine Decitabine omacetaxine mepesuccinate 0 1
Cytarabine + Decitabine + PCM-075 Cytarabine Decitabine PCM-075 0 1
Dasatinib + Decitabine Dasatinib Decitabine 0 1
DEC-205-NY-ESO-1 fusion protein vaccine + Decitabine DEC-205-NY-ESO-1 fusion protein vaccine Decitabine 0 1
DEC-205-NY-ESO-1 fusion protein vaccine + Decitabine + Nivolumab + Poly ICLC DEC-205-NY-ESO-1 fusion protein vaccine Decitabine Nivolumab Poly ICLC 0 1
Decitabine Decitabine 5 32
Decitabine + Eltrombopag Decitabine Eltrombopag 0 1
Decitabine + Enzalutamide Decitabine Enzalutamide 0 1
Decitabine + Gefitinib Decitabine Gefitinib 1 0
Decitabine + Genistein Decitabine Genistein 0 2
Decitabine + Glasdegib Decitabine Glasdegib 1 1
Decitabine + Inecalcitol Decitabine Inecalcitol 0 1
Decitabine + Ipilimumab Decitabine Ipilimumab 0 1
Decitabine + MBG453 Decitabine MBG453 0 2
Decitabine + MBG453 + Spartalizumab Decitabine MBG453 Spartalizumab 0 1
Decitabine + Midostaurin Decitabine Midostaurin 0 2
Decitabine + MLN4924 Decitabine MLN4924 0 1
Decitabine + Nivolumab + Tetrahydrouridine Decitabine Nivolumab Tetrahydrouridine 0 1
Decitabine + omacetaxine mepesuccinate Decitabine omacetaxine mepesuccinate 0 1
Decitabine + OPB-111077 Decitabine OPB-111077 0 1
Decitabine + Pacritinib Decitabine Pacritinib 0 3
Decitabine + Palbociclib Decitabine Palbociclib 0 1
Decitabine + Panobinostat + Temozolomide Decitabine Panobinostat Temozolomide 0 1
Decitabine + PCM-075 Decitabine PCM-075 0 1
Decitabine + Pembrolizumab Decitabine Pembrolizumab 0 4
Decitabine + Pembrolizumab + Pralatrexate Decitabine Pembrolizumab Pralatrexate 0 1
Decitabine + Plerixafor Decitabine Plerixafor 0 1
Decitabine + Quizartinib Decitabine Quizartinib 0 0
Decitabine + Ribavirin Decitabine Ribavirin 0 1
Decitabine + Ruxolitinib Decitabine Ruxolitinib 0 2
Decitabine + sapacitabine Decitabine sapacitabine 0 2
Decitabine + Selinexor Decitabine Selinexor 0 1
Decitabine + Sirolimus Decitabine Sirolimus 0 1
Decitabine + Sorafenib Decitabine Sorafenib 1 0
Decitabine + Spartalizumab Decitabine Spartalizumab 0 1
Decitabine + Talacotuzumab Decitabine Talacotuzumab 0 1
Decitabine + Talazoparib Decitabine Talazoparib 0 1
Decitabine + Tetrahydrouridine Decitabine Tetrahydrouridine 0 3
Decitabine + TK216 Decitabine TK216 0 1
Decitabine + TMU-35435 Decitabine TMU-35435 1 0
Decitabine + Vemurafenib Decitabine Vemurafenib 0 1
Decitabine + Venetoclax Decitabine Venetoclax 1 5
Decitabine + Volasertib Decitabine Volasertib 0 1
Decitabine + Vosaroxin Decitabine Vosaroxin 0 1


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