Drug Detail


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Drug Name MLN4924
Trade Name Pevonedistat
Synonyms MLN-4924
Drug Descriptions

Pevonedistat (MLN4924) binds and inhibits NEDD8, a ubiquitin-like protein, leading to inhibition of NFKB signaling, reduced transcription of target genes, and increased apoptosis in cancer cells with increased NFKB activity (PMID: 24634471, PMID: 29781056, PMID: 32721435).

CAS Registry Number 905579-51-3
NCIT ID C77906


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Azacitidine + Cytarabine + Fludarabine + MLN4924 Azacitidine Cytarabine Fludarabine MLN4924 0 1
Azacitidine + MLN4924 Azacitidine MLN4924 0 7
Azacitidine + MLN4924 + Venetoclax Azacitidine MLN4924 Venetoclax 0 3
Belinostat + MLN4924 Belinostat MLN4924 0 1
Carboplatin + Docetaxel + MLN4924 + Paclitaxel Carboplatin Docetaxel MLN4924 Paclitaxel 0 1
Carboplatin + MLN4924 + Paclitaxel Carboplatin MLN4924 Paclitaxel 0 2
Cisplatin + MLN4924 + Pemetrexed Disodium Cisplatin MLN4924 Pemetrexed Disodium 0 1
Cytarabine + Idarubicin + MLN4924 Cytarabine Idarubicin MLN4924 0 1
Cytarabine + MLN4924 Cytarabine MLN4924 0 1
Decitabine + MLN4924 Decitabine MLN4924 0 1
Dexamethasone + Doxorubicin + MLN4924 + Pegaspargase + Vincristine Sulfate Dexamethasone Doxorubicin MLN4924 Pegaspargase Vincristine Sulfate 0 1
Docetaxel + MLN4924 Docetaxel MLN4924 0 1
Ibrutinib + MLN4924 Ibrutinib MLN4924 0 1
Irinotecan + MLN4924 + Temozolomide Irinotecan MLN4924 Temozolomide 0 1
Ixazomib + MLN4924 Ixazomib MLN4924 0 1
MLN4924 MLN4924 0 5
MLN4924 + Pembrolizumab MLN4924 Pembrolizumab 0 1
MLN4924 + PLX4720 MLN4924 PLX4720 0 0
MLN4924 + Rifampin MLN4924 Rifampin 0 1

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