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Drug Name Ixazomib
Trade Name Ninlaro
Synonyms MLN9708
Drug Descriptions

Ninlaro (ixazomib) inhibits proteosome activity, resulting in accumulation of misfolded proteins, inhibition of pathway signaling, and potentially leading to cell death (PMID: 20160034). Ninlaro (ixazomib) in combination with Revlimid (lenalidomide) and dexamethasone is FDA approved for use in patients with multiple myeloma who have received at least one prior therapy (FDA.gov)

DrugClasses

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Dexamethasone + Ixazomib + Pomalidomide Abemaciclib Dexamethasone Ixazomib Pomalidomide 0 1
AZD7762 + Ixazomib AZD7762 Ixazomib 1 0
BMS-188667 + Dexamethasone + Ixazomib BMS-188667 Dexamethasone Ixazomib 0 1
Cobimetinib + Dexamethasone + Ixazomib + Pomalidomide Cobimetinib Dexamethasone Ixazomib Pomalidomide 0 1
Cyclophosphamide + Dexamethasone + Ixazomib + Nivolumab Cyclophosphamide Dexamethasone Ixazomib Nivolumab 0 1
Cytarabine + Daunorubicin + Ixazomib Cytarabine Daunorubicin Ixazomib 0 1
Daratumumab + Dexamethasone + Ixazomib Daratumumab Dexamethasone Ixazomib 0 2
Daratumumab + Dexamethasone + Ixazomib + Pomalidomide Daratumumab Dexamethasone Ixazomib Pomalidomide 0 1
Daratumumab + Ixazomib Daratumumab Ixazomib 0 1
Dexamethasone + Enasidenib + Ixazomib + Pomalidomide Dexamethasone Enasidenib Ixazomib Pomalidomide 0 1
Dexamethasone + Erdafitinib + Ixazomib + Pomalidomide Dexamethasone Erdafitinib Ixazomib Pomalidomide 0 1
Dexamethasone + Idasanutlin + Ixazomib Dexamethasone Idasanutlin Ixazomib 0 1
Dexamethasone + Ixazomib Dexamethasone Ixazomib 0 1
Dexamethasone + Ixazomib + Lenalidomide Dexamethasone Ixazomib Lenalidomide 1 2
Dexamethasone + Ixazomib + Lenalidomide + Tasquinimod Dexamethasone Ixazomib Lenalidomide Tasquinimod 0 1
Dexamethasone + Ixazomib + ONC201 Dexamethasone Ixazomib ONC201 0 1
Dexamethasone + Ixazomib + Panobinostat Dexamethasone Ixazomib Panobinostat 0 1
Dexamethasone + Ixazomib + Pembrolizumab Dexamethasone Ixazomib Pembrolizumab 0 1
Dexamethasone + Ixazomib + Pomalidomide + Venetoclax Dexamethasone Ixazomib Pomalidomide Venetoclax 0 1
Dexamethasone + Ixazomib + Selinexor Dexamethasone Ixazomib Selinexor 0 1
Doxorubicin + Gemcitabine + Ixazomib Doxorubicin Gemcitabine Ixazomib 0 1
DT204 + Ixazomib DT204 Ixazomib 1 0
Erlotinib + Ixazomib Erlotinib Ixazomib 0 1
Fulvestrant + Ixazomib Fulvestrant Ixazomib 0 1
Gemcitabine + Ixazomib Gemcitabine Ixazomib 0 1
Ibrutinib + Ixazomib Ibrutinib Ixazomib 0 2
Ixazomib Ixazomib 3 2
Ixazomib + JQ1 Ixazomib JQ1 2 0
Ixazomib + Lenalidomide + Rituximab Ixazomib Lenalidomide Rituximab 0 1
Ixazomib + Mivavotinib Ixazomib Mivavotinib 0 1
Ixazomib + MLN4924 Ixazomib MLN4924 0 1
Ixazomib + Rituximab Ixazomib Rituximab 0 3
Ixazomib + Romidepsin Ixazomib Romidepsin 0 1
Ixazomib + Selinexor Ixazomib Selinexor 0 1
Ixazomib + Vorinostat Ixazomib Vorinostat 1 1


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