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Drug Name Alectinib
Trade Name Alecensa
Synonyms CH5424802|RO5424802
Drug Descriptions

Alecensa (alectinib) is an inhibitor of RET and ALK, including ALK fusions and the gatekeeper mutation, L1196M (PMID: 21575866, PMID: 25349307). Alecensa (alectinib) is FDA-approved for use in patients with ALK-positive (rearrangements and fusions) non-small cell lung cancer (FDA.gov).

DrugClasses ALK Inhibitor 32 RET Inhibitor 52
CAS Registry Number 1256580-46-7
NCIT ID C101790

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Afatinib + Alectinib Afatinib Alectinib 2 0
Alectinib Alectinib 222 31
Alectinib + Atezolizumab Alectinib Atezolizumab 0 1
Alectinib + Capmatinib Alectinib Capmatinib 0 0
Alectinib + Carboplatin Alectinib Carboplatin 0 1
Alectinib + Cisplatin Alectinib Cisplatin 0 1
Alectinib + Cobimetinib Alectinib Cobimetinib 0 1
Alectinib + Crizotinib Alectinib Crizotinib 0 0
Alectinib + Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Etoposide + Ifosfamide + Methotrexate + Vindesine Alectinib Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Etoposide Ifosfamide Methotrexate Vindesine 0 0
Alectinib + Dasatinib Alectinib Dasatinib 0 0
Alectinib + Doxorubicin Alectinib Doxorubicin 1 0
Alectinib + Erlotinib Alectinib Erlotinib 0 0
Alectinib + Idasanutlin Alectinib Idasanutlin 4 0
Alectinib + Irinotecan Alectinib Irinotecan 1 0
Alectinib + Ixazomib Alectinib Ixazomib 2 0
Alectinib + Octreotide Alectinib Octreotide 1 0
Alectinib + Osimertinib Alectinib Osimertinib 0 1
Alectinib + Pertuzumab + Trastuzumab Alectinib Pertuzumab Trastuzumab 0 0
Alectinib + RMC-4550 Alectinib RMC-4550 1 0
Alectinib + Selumetinib Alectinib Selumetinib 1 0
Alectinib + SHP099 Alectinib SHP099 1 0
Alectinib + Trastuzumab Alectinib Trastuzumab 0 0
Alectinib + Zoledronic acid Alectinib Zoledronic acid 1 0


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