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| Drug Name | Crizotinib |
| Trade Name | Xalkori |
| Synonyms | PF-02341066 |
| Drug Descriptions |
Xalkori (crizotinib), inhibits ALK kinase, ALK fusion proteins, c-Met, ROS1 fusion proteins, and MST1R (RON), resulting in growth inhibition of tumor cells (PMID: 26951079, PMID: 22617245). Xalkori (crizotinib) is FDA approved for use in patients with ALK or ROS1 positive (rearrangements and fusions) non-small cell lung cancer, and in pediatric patients 1 year and older and young adults with relapsed or refractory, ALK-positive systemic anaplastic large cell lymphoma (FDA.gov). |
| DrugClasses | ALK Inhibitor 24 MET Inhibitor 54 RON Inhibitor 10 ROS1 Inhibitor 15 |
| CAS Registry Number | 877399-52-5 |
| NCIT ID | C74061 |
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