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| Drug Name | Crizotinib |
| Trade Name | Xalkori |
| Synonyms | PF-02341066 |
| Drug Descriptions |
Xalkori (crizotinib) inhibits ALK kinase, ALK fusion proteins, c-Met, ROS1 fusion proteins, and MST1R (RON), resulting in growth inhibition of tumor cells (PMID: 26951079, PMID: 22617245). Xalkori (crizotinib) is FDA approved for use in patients with ALK- or ROS1-positive (rearrangements and fusions) metastatic non-small cell lung cancer, in pediatric patients 1 year and older and young adults with relapsed or refractory, ALK-positive systemic anaplastic large cell lymphoma, and in adult and pediatric patients 1 year and older with ALK-positive, unresectable, recurrent, or refractory inflammatory myofibroblastic tumor (FDA.gov). |
| DrugClasses | ALK Inhibitor 32 BCR-ABL Inhibitor 31 MET Inhibitor 59 RON Inhibitor 11 ROS1 Inhibitor 20 |
| CAS Registry Number | 877399-52-5 |
| NCIT ID | C74061 |
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