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Drug Name Crizotinib
Trade Name Xalkori
Synonyms PF-02341066
Drug Descriptions

Xalkori (crizotinib), inhibits ALK kinase, ALK fusion proteins, c-Met, ROS1 fusion proteins, and MST1R (RON), resulting in growth inhibition of tumor cells (PMID: 26951079, PMID: 22617245). Xalkori (crizotinib) is FDA approved for use in patients with ALK or ROS1 positive (rearrangements and fusions) non-small cell lung cancer (FDA.gov).

DrugClasses ALK Inhibitor 23 MET Inhibitor 52 RON Inhibitor 10 ROS1 Inhibitor 14

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Afatinib + Crizotinib Afatinib Crizotinib 0 0
Afatinib + Crizotinib + Trametinib Afatinib Crizotinib Trametinib 0 0
Alpelisib + Crizotinib Alpelisib Crizotinib 0 0
Alvocidib + Crizotinib Alvocidib Crizotinib 1 0
Axitinib + Crizotinib Axitinib Crizotinib 0 1
AZD4547 + Crizotinib AZD4547 Crizotinib 0 0
Bemcentinib + Crizotinib Bemcentinib Crizotinib 0 0
Brentuximab vedotin + Crizotinib Brentuximab vedotin Crizotinib 0 0
Buparlisib + Crizotinib Buparlisib Crizotinib 0 0
Ceritinib + Crizotinib Ceritinib Crizotinib 1 0
Copanlisib + Crizotinib Copanlisib Crizotinib 0 0
Crizotinib Crizotinib 156 33
Crizotinib + Cyclophosphamide + Topotecan Crizotinib Cyclophosphamide Topotecan 1 0
Crizotinib + Dacomitinib Crizotinib Dacomitinib 0 0
Crizotinib + Dasatinib Crizotinib Dasatinib 1 2
Crizotinib + Enzalutamide Crizotinib Enzalutamide 0 1
Crizotinib + Erlotinib Crizotinib Erlotinib 0 0
Crizotinib + Filgotinib Crizotinib Filgotinib 1 0
Crizotinib + Ganetespib Crizotinib Ganetespib 0 1
Crizotinib + Gefitinib Crizotinib Gefitinib 0 0
Crizotinib + Gemcitabine Crizotinib Gemcitabine 0 0
Crizotinib + Infigratinib Crizotinib Infigratinib 0 0
Crizotinib + Ipilimumab Crizotinib Ipilimumab 0 1
Crizotinib + Itraconazole Crizotinib Itraconazole 0 1
Crizotinib + Itraconazole + Rifampin Crizotinib Itraconazole Rifampin 0 0
Crizotinib + Lapatinib Crizotinib Lapatinib 0 0
Crizotinib + Lapatinib + Linsitinib Crizotinib Lapatinib Linsitinib 0 0
Crizotinib + Linsitinib Crizotinib Linsitinib 0 0
Crizotinib + Lorlatinib Crizotinib Lorlatinib 0 1
Crizotinib + LOXO-195 Crizotinib LOXO-195 0 0
Crizotinib + Navitoclax Crizotinib Navitoclax 1 0
Crizotinib + Nivolumab Crizotinib Nivolumab 0 1
Crizotinib + Onalespib Crizotinib Onalespib 2 0
Crizotinib + Osimertinib Crizotinib Osimertinib 0 0
Crizotinib + Paclitaxel + Trastuzumab Crizotinib Paclitaxel Trastuzumab 0 0
Crizotinib + Pazopanib Crizotinib Pazopanib 0 1
Crizotinib + Pazopanib + Pemetrexed Disodium Crizotinib Pazopanib Pemetrexed Disodium 0 1
Crizotinib + Pemetrexed Disodium Crizotinib Pemetrexed Disodium 0 2
Crizotinib + PLX4720 Crizotinib PLX4720 0 0
Crizotinib + Regorafenib Crizotinib Regorafenib 0 0
Crizotinib + Rifampin Crizotinib Rifampin 0 1
Crizotinib + Rociletinib Crizotinib Rociletinib 0 0
Crizotinib + Rucaparib Crizotinib Rucaparib 0 0
Crizotinib + Selumetinib Crizotinib Selumetinib 0 0
Crizotinib + Sunitinib Crizotinib Sunitinib 0 1
Crizotinib + Trametinib Crizotinib Trametinib 0 0
Crizotinib + Vemurafenib Crizotinib Vemurafenib 0 1
Crizotinib + WZ4002 Crizotinib WZ4002 0 0


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