Drug Detail


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Drug Name RMC-4550
Trade Name
Synonyms RMC4550|RMC 4550
Drug Descriptions

RMC-4550 is a small molecule allosteric inhibitor of Shp2 that blocks Ras-Raf-Mek-Erk pathway signaling, leading to tumor growth inhibition (PMID: 30104724).

DrugClasses SHP2 Inhibitor 20
CAS Registry Number 2172651-73-7


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Adagrasib + RMC-4550 Adagrasib RMC-4550 0 0
Alectinib + RMC-4550 Alectinib RMC-4550 1 0
Alpelisib + RMC-4550 + Sotorasib Alpelisib RMC-4550 Sotorasib 0 0
AZD4625 + RMC-4550 AZD4625 RMC-4550 0 0
BAY-293 + Osimertinib + RMC-4550 BAY-293 Osimertinib RMC-4550 0 0
BAY-293 + RMC-4550 BAY-293 RMC-4550 0 0
Crizotinib + RMC-4550 Crizotinib RMC-4550 0 0
D-1553 + RMC-4550 D-1553 RMC-4550 0 0
Gilteritinib + RMC-4550 Gilteritinib RMC-4550 2 0
Ipatasertib + RMC-4550 + Sotorasib Ipatasertib RMC-4550 Sotorasib 0 0
LY3214996 + RMC-4550 LY3214996 RMC-4550 0 0
Osimertinib + RMC-4550 Osimertinib RMC-4550 0 0
Pictilisib + RMC-4550 + Sotorasib Pictilisib RMC-4550 Sotorasib 0 0
RMC-4550 RMC-4550 20 0
RMC-4550 + Sotorasib RMC-4550 Sotorasib 0 0
RMC-4550 + Venetoclax RMC-4550 Venetoclax 3 0

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