Drug Detail


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Drug Name Gilteritinib
Trade Name Xospata
Synonyms ASP2215
Drug Descriptions

Xospata (gilteritinib) is a small molecule inhibitor of FLT3 and AXL that has activity against FLT3-ITD, FLT3 F691L, and FLT3 D835 mutations, potentially resulting in decreased tumor growth (J Clin Oncol 32:5s, 2014 (suppl; abstr 7070), PMID: 25891481). Xospata (gilteritinib) is FDA approved for use in patients with relapsed or refractory acute myeloid leukemia (AML) with a FLT3 mutation (ITD, D835X, and I836X) (FDA.gov).

DrugClasses AXL Inhibitor 28 FLT3 Inhibitor 60
CAS Registry Number 1254053-43-4
NCIT ID C116722


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + Gilteritinib Atezolizumab Gilteritinib 0 1
Azacitidine + Gilteritinib Azacitidine Gilteritinib 0 1
Azacitidine + Gilteritinib + Venetoclax Azacitidine Gilteritinib Venetoclax 0 1
CC-90009 + Gilteritinib CC-90009 Gilteritinib 0 1
CPX-351 + Gilteritinib CPX-351 Gilteritinib 0 1
CUDC-907 + Gilteritinib CUDC-907 Gilteritinib 1 0
Cytarabine + Daunorubicin + Gilteritinib Cytarabine Daunorubicin Gilteritinib 0 1
Cytarabine + Filgrastim + Fludarabine + Gilteritinib Cytarabine Filgrastim Fludarabine Gilteritinib 0 1
Decitabine and Cedazuridine + Gilteritinib Decitabine and Cedazuridine Gilteritinib 0 1
Decitabine and Cedazuridine + Gilteritinib + Venetoclax Decitabine and Cedazuridine Gilteritinib Venetoclax 0 1
ERAS-007 + Gilteritinib ERAS-007 Gilteritinib 0 1
ERAS-601 + Gilteritinib ERAS-601 Gilteritinib 1 0
Gilteritinib Gilteritinib 152 9
Gilteritinib + Glasdegib Gilteritinib Glasdegib 0 1
Gilteritinib + LAM-003 Gilteritinib LAM-003 1 0
Gilteritinib + Lanraplenib Gilteritinib Lanraplenib 0 1
Gilteritinib + Osimertinib Gilteritinib Osimertinib 0 0
Gilteritinib + OTS167 Gilteritinib OTS167 1 0
Gilteritinib + Palbociclib Gilteritinib Palbociclib 0 0
Gilteritinib + PRT062607 Gilteritinib PRT062607 1 0
Gilteritinib + Ruxolitinib Gilteritinib Ruxolitinib 3 0
Gilteritinib + Sotorasib Gilteritinib Sotorasib 0 0
Gilteritinib + Venetoclax Gilteritinib Venetoclax 2 1

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