Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Gilteritinib
Trade Name Xospata
Synonyms ASP2215
Drug Descriptions

Xospata (gilteritinib) is a small molecule inhibitor of FLT3 and AXL that has activity against FLT3-ITD, FLT3 F691L, and FLT3 D835 mutations, potentially resulting in decreased tumor growth (J Clin Oncol 32:5s, 2014 (suppl; abstr 7070), PMID: 25891481). Xospata (gilteritinib) is FDA approved for use in patients with relapsed or refractory acute myeloid leukemia (AML) with a FLT3 mutation (ITD, D835X, and I836X) (FDA.gov).

DrugClasses AXL Inhibitor 30 FLT3 Inhibitor 66
CAS Registry Number 1254053-43-4
NCIT ID C116722

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + Gilteritinib Atezolizumab Gilteritinib 0 1
Azacitidine + Cytarabine + Daunorubicin + Etoposide + Fludarabine + Gemtuzumab ozogamicin + Gilteritinib + Idarubicin + Venetoclax Azacitidine Cytarabine Daunorubicin Etoposide Fludarabine Gemtuzumab ozogamicin Gilteritinib Idarubicin Venetoclax 0 1
Azacitidine + Gilteritinib Azacitidine Gilteritinib 0 2
Azacitidine + Gilteritinib + Venetoclax Azacitidine Gilteritinib Venetoclax 2 2
CC-90009 + Gilteritinib CC-90009 Gilteritinib 0 1
Cladribine + Cytarabine + Filgrastim + Gilteritinib + Mitoxantrone Cladribine Cytarabine Filgrastim Gilteritinib Mitoxantrone 0 1
CPX-351 + Gilteritinib CPX-351 Gilteritinib 0 1
CUDC-907 + Gilteritinib CUDC-907 Gilteritinib 1 0
Cytarabine + Daunorubicin + Etoposide + Fludarabine + Gemtuzumab ozogamicin + Gilteritinib + Idarubicin + mitoxantrone hydrochloride + Venetoclax Cytarabine Daunorubicin Etoposide Fludarabine Gemtuzumab ozogamicin Gilteritinib Idarubicin Venetoclax mitoxantrone hydrochloride 0 1
Cytarabine + Daunorubicin + Etoposide + Gemtuzumab ozogamicin + Gilteritinib + mitoxantrone hydrochloride + Venetoclax Cytarabine Daunorubicin Etoposide Gemtuzumab ozogamicin Gilteritinib Venetoclax mitoxantrone hydrochloride 0 1
Cytarabine + Daunorubicin + Gilteritinib Cytarabine Daunorubicin Gilteritinib 1 1
Cytarabine + Filgrastim + Fludarabine + Gilteritinib Cytarabine Filgrastim Fludarabine Gilteritinib 0 1
Decitabine and Cedazuridine + Gilteritinib Decitabine and Cedazuridine Gilteritinib 0 1
Decitabine and Cedazuridine + Gilteritinib + Venetoclax Decitabine and Cedazuridine Gilteritinib Venetoclax 0 1
Enasidenib + Gilteritinib Enasidenib Gilteritinib 0 1
ERAS-007 + Gilteritinib ERAS-007 Gilteritinib 0 1
ERAS-601 + Gilteritinib ERAS-601 Gilteritinib 1 0
Gilteritinib Gilteritinib 221 10
Gilteritinib + Glasdegib Gilteritinib Glasdegib 0 1
Gilteritinib + Ivosidenib Gilteritinib Ivosidenib 0 1
Gilteritinib + LAM-003 Gilteritinib LAM-003 1 0
Gilteritinib + Lanraplenib Gilteritinib Lanraplenib 0 1
Gilteritinib + MI-503 Gilteritinib MI-503 0 0
Gilteritinib + Momelotinib Gilteritinib Momelotinib 0 1
Gilteritinib + ORY-1001 Gilteritinib ORY-1001 0 1
Gilteritinib + Osimertinib Gilteritinib Osimertinib 0 0
Gilteritinib + OTS167 Gilteritinib OTS167 1 0
Gilteritinib + Palbociclib Gilteritinib Palbociclib 0 0
Gilteritinib + PRT062607 Gilteritinib PRT062607 1 0
Gilteritinib + Revumenib Gilteritinib Revumenib 0 1
Gilteritinib + RMC-4550 Gilteritinib RMC-4550 2 0
Gilteritinib + Ruxolitinib Gilteritinib Ruxolitinib 2 0
Gilteritinib + Sotorasib Gilteritinib Sotorasib 0 0
Gilteritinib + Trametinib Gilteritinib Trametinib 2 0
Gilteritinib + Venetoclax Gilteritinib Venetoclax 2 1
Gilteritinib + VTP50469 Gilteritinib VTP50469 0 0
Gilteritinib + Ziftomenib Gilteritinib Ziftomenib 0 1


Additional content available in CKB BOOST