Drug Detail

Drug Name Gemtuzumab ozogamicin
Trade Name Mylotarg
Synonyms gemtuzumab|CDP-771|CMA-676|WAY-CMA-676
Drug Descriptions

Mylotarg (gemtuzumab ozogamicin) is an antibody-drug conjugate comprising an anti-CD33 antibody linked to the cytotoxic agent calicheamicin, which results in DNA damage in CD33-expressing tumor cells (PMID: 28607471). Mylotarg (gemtuzumab ozogamicin) is FDA approved for CD33-positive acute myeloid leukemia (FDA.gov).

DrugClasses

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Arsenic trioxide + Gemtuzumab ozogamicin + Tretinoin Arsenic trioxide Gemtuzumab ozogamicin Tretinoin 0 2
Atovaquone + Cytarabine + Daunorubicin + Gemtuzumab ozogamicin Atovaquone Cytarabine Daunorubicin Gemtuzumab ozogamicin 0 1
Busulfan + Cyclophosphamide + Gemtuzumab ozogamicin Busulfan Cyclophosphamide Gemtuzumab ozogamicin 0 1
Cladribine + Cytarabine + Filgrastim + Gemtuzumab ozogamicin + Mitoxantrone Cladribine Cytarabine Filgrastim Gemtuzumab ozogamicin Mitoxantrone 0 1
CPX-351 + Gemtuzumab ozogamicin CPX-351 Gemtuzumab ozogamicin 0 3
Cytarabine + Daunorubicin + Gemtuzumab ozogamicin Cytarabine Daunorubicin Gemtuzumab ozogamicin 0 1
Cytarabine + Daunorubicin + Gemtuzumab ozogamicin + Midostaurin Cytarabine Daunorubicin Gemtuzumab ozogamicin Midostaurin 0 0
Cytarabine + Filgrastim + Fludarabine + Gemtuzumab ozogamicin Cytarabine Filgrastim Fludarabine Gemtuzumab ozogamicin 0 1
Cytarabine + Filgrastim + Fludarabine + Gemtuzumab ozogamicin + Idarubicin Cytarabine Filgrastim Fludarabine Gemtuzumab ozogamicin Idarubicin 0 1
Cytarabine + Gemtuzumab ozogamicin Cytarabine Gemtuzumab ozogamicin 0 1
Etoposide + Gemtuzumab ozogamicin + Mitoxantrone Etoposide Gemtuzumab ozogamicin Mitoxantrone 0 1
Gemtuzumab ozogamicin Gemtuzumab ozogamicin 0 5
Gemtuzumab ozogamicin + Glasdegib Gemtuzumab ozogamicin Glasdegib 0 1
Gemtuzumab ozogamicin + Pracinostat Gemtuzumab ozogamicin Pracinostat 0 1


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