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Drug Name Gemtuzumab ozogamicin
Trade Name Mylotarg
Synonyms gemtuzumab|CDP-771|CMA-676|WAY-CMA-676
Drug Descriptions

Mylotarg (gemtuzumab ozogamicin) is an antibody-drug conjugate comprising an anti-CD33 antibody linked to the cytotoxic agent calicheamicin, which results in DNA damage in CD33-expressing tumor cells (PMID: 28607471). Mylotarg (gemtuzumab ozogamicin) is FDA approved for newly-diagnosed CD33-positive acute myeloid leukemia (AML) in adult and pediatric patients 1 month and older, and in relapsed or refractory CD33-positive AML in adult and pediatric patients 2 years and older (FDA.gov).

DrugClasses CD33 Antibody 12
CAS Registry Number 220578-59-6
NCIT ID C1806

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Arsenic trioxide + Gemtuzumab ozogamicin + Tretinoin Arsenic trioxide Gemtuzumab ozogamicin Tretinoin 0 3
Atovaquone + Cytarabine + Daunorubicin + Gemtuzumab ozogamicin Atovaquone Cytarabine Daunorubicin Gemtuzumab ozogamicin 0 1
Azacitidine + Cytarabine + Daunorubicin + Etoposide + Fludarabine + Gemtuzumab ozogamicin + Gilteritinib + Idarubicin + Venetoclax Azacitidine Cytarabine Daunorubicin Etoposide Fludarabine Gemtuzumab ozogamicin Gilteritinib Idarubicin Venetoclax 0 1
Azacitidine + Cytarabine + Fludarabine + Gemtuzumab ozogamicin Azacitidine Cytarabine Fludarabine Gemtuzumab ozogamicin 0 1
Azacitidine + Cytarabine + Fludarabine + Gemtuzumab ozogamicin + Venetoclax Azacitidine Cytarabine Fludarabine Gemtuzumab ozogamicin Venetoclax 0 1
Bortezomib + Gemtuzumab ozogamicin Bortezomib Gemtuzumab ozogamicin 0 1
Busulfan + Cyclophosphamide + Gemtuzumab ozogamicin Busulfan Cyclophosphamide Gemtuzumab ozogamicin 0 1
Cladribine + Cytarabine + Filgrastim + Gemtuzumab ozogamicin Cladribine Cytarabine Filgrastim Gemtuzumab ozogamicin 0 1
Cladribine + Cytarabine + Filgrastim + Gemtuzumab ozogamicin + Mitoxantrone Cladribine Cytarabine Filgrastim Gemtuzumab ozogamicin Mitoxantrone 0 1
CPX-351 + Gemtuzumab ozogamicin CPX-351 Gemtuzumab ozogamicin 0 5
Cytarabine + Daunorubicin + Etoposide + Fludarabine + Gemtuzumab ozogamicin + Gilteritinib + Idarubicin + mitoxantrone hydrochloride + Venetoclax Cytarabine Daunorubicin Etoposide Fludarabine Gemtuzumab ozogamicin Gilteritinib Idarubicin Venetoclax mitoxantrone hydrochloride 0 1
Cytarabine + Daunorubicin + Etoposide + Gemtuzumab ozogamicin Cytarabine Daunorubicin Etoposide Gemtuzumab ozogamicin 0 1
Cytarabine + Daunorubicin + Etoposide + Gemtuzumab ozogamicin + Gilteritinib + mitoxantrone hydrochloride + Venetoclax Cytarabine Daunorubicin Etoposide Gemtuzumab ozogamicin Gilteritinib Venetoclax mitoxantrone hydrochloride 0 1
Cytarabine + Daunorubicin + Etoposide + Gemtuzumab ozogamicin + Sorafenib Cytarabine Daunorubicin Etoposide Gemtuzumab ozogamicin Sorafenib 0 1
Cytarabine + Daunorubicin + Gemtuzumab ozogamicin Cytarabine Daunorubicin Gemtuzumab ozogamicin 0 3
Cytarabine + Daunorubicin + Gemtuzumab ozogamicin + Midostaurin Cytarabine Daunorubicin Gemtuzumab ozogamicin Midostaurin 0 1
Cytarabine + Filgrastim + Fludarabine + Gemtuzumab ozogamicin Cytarabine Filgrastim Fludarabine Gemtuzumab ozogamicin 0 1
Cytarabine + Filgrastim + Fludarabine + Gemtuzumab ozogamicin + Idarubicin Cytarabine Filgrastim Fludarabine Gemtuzumab ozogamicin Idarubicin 0 1
Cytarabine + Gemtuzumab ozogamicin Cytarabine Gemtuzumab ozogamicin 0 1
Etoposide + Gemtuzumab ozogamicin + Mitoxantrone Etoposide Gemtuzumab ozogamicin Mitoxantrone 0 1
Gemtuzumab ozogamicin Gemtuzumab ozogamicin 0 10
Gemtuzumab ozogamicin + Glasdegib Gemtuzumab ozogamicin Glasdegib 0 3
Gemtuzumab ozogamicin + Pracinostat Gemtuzumab ozogamicin Pracinostat 0 1
Gemtuzumab ozogamicin + Talazoparib Gemtuzumab ozogamicin Talazoparib 0 1
Gemtuzumab ozogamicin + Venetoclax Gemtuzumab ozogamicin Venetoclax 0 1


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